US4493847A
Expired / Lapsed
US
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Fat emulsion containing prostaglandin E1 and method for production thereof
Assignee: Taisho Pharmaceutical Co Ltd
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Filing: 1983-06-13
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Granted: 1985-01-15
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Expires: 2003-06-13
Abstract
Abstract A fat emulsion for injection containing prostaglandin E1 which has a vasodilative action as well as a hypotensive action and a method for the production of such an emulsion. The present emulsion is effective in treating chronic arteriostenosis diseases.
Inventors
- 👤 Yutaka Mizushima
- 👤 Hironaka Aihara
- 👤 Susumu Otomo
- 👤 Kazumasa Yokoyama
- 👤 Hiroyuki Okamoto
- 👤 Tadakazu Suyama
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 01:17
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/557; A61K9/00; A61K9/10; A61K9/107; A61K9/1075; A61P; A61P43/00
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
42 words
A fat emulsion containing prostaglandin E, which comprises 5-50%(W/V) of soybean oil, an effective amount of prostaglandin E 1 , 1-50 parts by weight of a phospholipid for 100 parts by weight of the soybean oil, and a proper amount of water.
Claim 2
Dependent Claim
42 words
A fat emulsion containing prostaglandin E, which comprises 5-50%(W/V) of soybean oil, an effective amount of prostaglandin E 1 , 1-50 parts by weight of a phospholipid for 100 parts by weight of the soybean oil, and a proper amount of water.
Claim 3
Dependent Claim
27 words
A fat emulsion according to claim 1, which contains as emulsifying adjuvant, 0.01-0.3%(W/V) of a fatty acid having 6-22 carbon atoms or a physiologically acceptable salt thereof.
Claim 4
Dependent Claim
21 words
A fat emulsion according to claim 1, which contains as stabilizer, 0.001-0.5%(W/V) of a cholesterol or 0.01-5%(W/V) of a phosphatidic acid.
Claim 5
Dependent Claim
49 words
A fat emulsion according to claim 1, which contains as stabilizing adjuvant, 0.1-5 parts by weight of at least one high-molecular-weight substance selected from the group consisting of albumin, dextran, vinyl polymers, nonionic surface active agents, gelatin, and hydroxyethylstarch for 1 part by weight of prostaglandin E 1 .
Claim 6
Dependent Claim
12 words
A fat emulsion according to claim 1, which contains an isotonizing agent.
Claim 7
Independent Claim
44 words
A method for producing a fat emulsion containing prostaglandin E 1 , which comprises dissolving prostaglandin E 1 and a phospholipid in soybean oil, mixing the resulting solution with a proper amount of water to form a coarse emulsion, and homogenizing the coarse emulsion.
Claim 8
Independent Claim
44 words
A method for producing a fat emulsion containing prostaglandin E 1 , which comprises dissolving prostaglandin E 1 and a phospholipid in soybean oil, mixing the resulting solution with a proper amount of water to form a coarse emulsion, and homogenizing the coarse emulsion.
Claim 9
Dependent Claim
47 words
A method according to claim 6, wherein a fat emulsion comprising an effective amount of prostaglandin E 1 , 5-50%(W/V) of soybean oil, 1-50 parts by weight of a phospholipid for 100 parts by weight of the soybean oil, and a proper amount of water is produced.
Claim 10
Dependent Claim
46 words
A method according to claim 6, wherein the homogenization is performed by passing the coarse emulsion through a high pressure-jet type homogenizer 1 -2 times under a first-stage pressure of 100-150 kg/cm 2 and then 5-15 times under a second-stage pressure of 400-700 kg/cm 2 .
Claim 11
Dependent Claim
18 words
A method according to claim 6, wherein the dissolution, mixing, and homogenization are carried out at 20°-80° C.
Claim 12
Dependent Claim
31 words
A method according to claim 6, wherein 0.01-0.3%(W/V) of a fatty acid having 6-22 carbon atoms or a physiologically acceptable salt thereof is added as emulsifying adjuvant in the dissolution step.
Claim 13
Dependent Claim
28 words
A method according to claim 6, wherein 0.001-0.5%(W/V) of a cholesterol or 0.01-5%(W/V) of a phosphatidic acid is added as stabilizer of fat emulsion in the dissolution step.
Claim 14
Dependent Claim
50 words
A method according to claim 6, wherein 0.1-5 parts by weight of at least one high-molecular-weight substance selected from the group consisting of albumin, dextran, vinyl polymers, nonionic surface active agents, gelatin, and hydroxyethylstarch for 1 part by weight of the prostaglandin E 1 is added in the mixing step.
Claim 15
Dependent Claim
16 words
A method according to claim 6, wherein an isotonizing agent is added in the mixing step.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-01-15 | 1988-07-16 | 1989-01-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-01-15 | 1992-07-16 | 1993-01-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-01-15 | 1996-07-16 | 1997-01-15 | $7700.00 | Window Closed / Lapsed |