US4493839A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1-Carbapenem-3-carboxylic esters as anti-inflammatory agents
Assignee: Merck and Co Inc
•
Filing: 1982-05-24
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Granted: 1985-01-15
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Expires: 2002-05-24
Abstract
Abstract Derivatives of 1-carbapenem-3-carboxylic esters are found to be potent elastase inhibitors and therefore are useful anti-inflammatory agents.
Inventors
- 👤 James B. Doherty
- 👤 Morris Zimmerman
- 👤 Bonnie M. Ashe
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 13:17
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/40; C; C07; C07D; C07D477/00; C07D477/10
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
96 words
A method of treating anti-inflammatory conditions comprising the administration to a mammalian species in need of such treatment a therapeutic effective amount of a pharmaceutical composition containing an active compound of formula: ##STR29## wherein R 1 and R 2 are the same or different and are (a) hydrogen; (b) CH 3 CH(OH)-- or CH 2 (OH)--; ##STR30## (d) when R 1 and R 2 are joined together, CH 3 CH═; or ##STR31## R is ##STR32## (c) --SCH 2 CH 2 OH; ##STR33## ##STR34## or (f) hydrogen; B is benzyl or benzyl substituted with NO 2 .
Claim 2
Independent Claim
96 words
A method of treating anti-inflammatory conditions comprising the administration to a mammalian species in need of such treatment a therapeutic effective amount of a pharmaceutical composition containing an active compound of formula: ##STR29## wherein R 1 and R 2 are the same or different and are (a) hydrogen; (b) CH 3 CH(OH)-- or CH 2 (OH)--; ##STR30## (d) when R 1 and R 2 are joined together, CH 3 CH═; or ##STR31## R is ##STR32## (c) --SCH 2 CH 2 OH; ##STR33## ##STR34## or (f) hydrogen; B is benzyl or benzyl substituted with NO 2 .
Claim 3
Dependent Claim
13 words
The method according to claim 1 wherein the compound is of formula: ##STR35##
Claim 4
Dependent Claim
13 words
The method according to claim 1 wherein the compound is of formula ##STR36##
Claim 5
Dependent Claim
98 words
A pharmaceutical composition for treating inflammatory conditions, fever and pain in mammalian species comprising a non-toxic pharmaceutical carrier and a therapeutic effective amount of a pharmaceutical composition containing an active compound of structural formula: ##STR37## wherein R 1 and R 2 are the same or different and are (a) hydrogen; (b) CH 3 CH(OH)-- or CH 2 (OH)--; ##STR38## (d) when R 1 and R 2 are joined together, CH 3 CH═; or ##STR39## R is ##STR40## (c) --SCH 2 CH 2 OH; ##STR41## ##STR42## or (f) hydrogen; B is benzyl or benzyl substituted with NO 2 .
Claim 6
Dependent Claim
98 words
A pharmaceutical composition for treating inflammatory conditions, fever and pain in mammalian species comprising a non-toxic pharmaceutical carrier and a therapeutic effective amount of a pharmaceutical composition containing an active compound of structural formula: ##STR37## wherein R 1 and R 2 are the same or different and are (a) hydrogen; (b) CH 3 CH(OH)-- or CH 2 (OH)--; ##STR38## (d) when R 1 and R 2 are joined together, CH 3 CH═; or ##STR39## R is ##STR40## (c) --SCH 2 CH 2 OH; ##STR41## ##STR42## or (f) hydrogen; B is benzyl or benzyl substituted with NO 2 .
Claim 7
Dependent Claim
13 words
The composition according to claim 4 wherein the compound is of formula: ##STR43##
Claim 8
Dependent Claim
13 words
The composition according to claim 4 wherein the compound is of formula ##STR44##
References Cited (Backward Citations)
US3546211A
Cited
BE860962A
Cited
EP0001627A1
Cited
US4347368A
Cited
US4347367A
Cited
US4269873A
Cited
EP0040408A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-01-15 | 1988-07-16 | 1989-01-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-01-15 | 1992-07-16 | 1993-01-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-01-15 | 1996-07-16 | 1997-01-15 | $7700.00 | Window Closed / Lapsed |