US4493837A
Expired / Lapsed
US
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Theobromine derivatives
Assignee: Eisai Co Ltd
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Filing: 1982-10-20
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Granted: 1985-01-15
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Expires: 2002-10-20
Abstract
Abstract There are disclosed theobromine derivatives wherein theobromine is substituted at the 1 position with substituted piperazino, homopiperazino and piperidino groups, and pharmacologically acceptable acid addition salts thereof. The compounds exhibit vasodilating and psychotropic and analgesic activities.
Inventors
- 👤 Hachiro Sugimoto
- 👤 Sachiyuki Hamano
- 👤 Tadao Shoji
- 👤 Takeru Kaneko
- 👤 Takeshi Uzuo
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 14:49
CPC Classifications
C; C07; C07D; C07D491/00; C07D491/02; C07D491/10; A; A61; A61P; A61P25/00; A61P9/00; A61P9/08; C07D473/00; C07D473/02; C07D473/04; C07D473/06; C07D473/10
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
140 words
A compound having the formula ##STR103## wherein Z is a member selected from the group consisting of A. a group having the formula ##STR104## wherein m is the integer 2 or the integer 3, and R 1 is pyridyl or a group having the formula ##STR105## wherein X 1 and X 2 , which can be the same or different, each is hydrogen, lower alkyl, lower alkoxy, trifluoromethyl or halogen, and a is an integer of 0 to 3; B. a group having the formula ##STR106## C. a group having the formula ##STR107## D. a group having the formula ##STR108## and E. a group having the formula ##STR109## and n is an integer of 2 to 8, with the proviso that when Z is ##STR110## n is an integer of 3 to 8, and pharmaceutically acceptable acid addition salts thereof.
Claim 2
Dependent Claim
140 words
A compound having the formula ##STR103## wherein Z is a member selected from the group consisting of A. a group having the formula ##STR104## wherein m is the integer 2 or the integer 3, and R 1 is pyridyl or a group having the formula ##STR105## wherein X 1 and X 2 , which can be the same or different, each is hydrogen, lower alkyl, lower alkoxy, trifluoromethyl or halogen, and a is an integer of 0 to 3; B. a group having the formula ##STR106## C. a group having the formula ##STR107## D. a group having the formula ##STR108## and E. a group having the formula ##STR109## and n is an integer of 2 to 8, with the proviso that when Z is ##STR110## n is an integer of 3 to 8, and pharmaceutically acceptable acid addition salts thereof.
Claim 3
Dependent Claim
103 words
The compound as set forth in claim 1 having the formula ##STR111## wherein m is the integer 2 or the integer 3 and R 1 is pyridyl or a group having the formula ##STR112## wherein X 1 and X 2 , which can be the same or different, each is hydrogen, lower alkyl, lower alkoxy, trifluoromethyl or halogen, and a is an integer of 0 to 3; and n is an integer of 2 to 8, with the proviso that when m is 2 and R 1 is the group expressed by the formula ##STR113## n is an integer of 3 to 8.
Claim 4
Dependent Claim
12 words
The compound as set forth in claim 1 having the formula ##STR114##
Claim 5
Dependent Claim
12 words
The compound as set forth in claim 1 having the formula ##STR115##
Claim 6
Dependent Claim
12 words
The compound as set forth in claim 1 having the formula ##STR116##
Claim 7
Dependent Claim
12 words
The compound as set forth in claim 1 having the formula ##STR117##
Claim 8
Dependent Claim
12 words
The compound as set forth in claim 1 having the formula ##STR118##
Claim 9
Dependent Claim
12 words
The compound as set forth in claim 1 having the formula ##STR119##
Claim 10
Dependent Claim
26 words
A pharmaceutical composition comprising a therapeutically effective amount of a compound as claimed in claim 1, for vasodilating purposes, in combination with a pharmacologically acceptable carrier.
Claim 11
Dependent Claim
26 words
A pharmaceutical composition comprising a therapeutically effective amount of a compound as claimed in claim 1, for tranquilizing purposes, in combination with a pharmacologically acceptable carrier.
Claim 12
Dependent Claim
25 words
A method for treating a subject suffering from blood circulatory insufficiency which comprises administering to the subject a pharmaceutical composition as claimed in claim 9.
Claim 13
Dependent Claim
24 words
A method for treating a subject suffering from psychotropic illness which comprises administering to the subject a pharmaceutical composition as claimed in claim 10.
Claim 14
Dependent Claim
26 words
A pharmaceutical composition comprising a therapeutically effective amount of a compound as claimed in claim 1, for analogesic purposes, in combination with a pharmacologically acceptable carrier.
Claim 15
Dependent Claim
24 words
A method for treating a subject suffering from a pain which comprises administering to the subject a pharmaceutical composition as claimed in claim 13.
Claim 16
Dependent Claim
66 words
The compound having the formula ##STR120## wherein X 1 and X 2 , which are the same or different, each is hydrogen, lower alkyl, lower alkoxy, trifluoromethyl or halogen, and n is an integer of 2 to 8, with the proviso that when X 1 and X 2 are both hydrogen, n is an integer of 3 to 8, and pharmacologically acceptable acid addition salts thereof.
Claim 17
Dependent Claim
66 words
The compound having the formula ##STR120## wherein X 1 and X 2 , which are the same or different, each is hydrogen, lower alkyl, lower alkoxy, trifluoromethyl or halogen, and n is an integer of 2 to 8, with the proviso that when X 1 and X 2 are both hydrogen, n is an integer of 3 to 8, and pharmacologically acceptable acid addition salts thereof.
Claim 18
Dependent Claim
19 words
The compound as set forth in claim 15 having the formula ##STR121## and pharmacologically acceptable acid addition salts thereof.
Claim 19
Dependent Claim
19 words
The compound as set forth in claim 15 having the formula ##STR122## and pharmacologically acceptable acid addition salts thereof.
Claim 20
Dependent Claim
21 words
The compound as set forth in claim 1 or claim 15 wherein n is an integer of 4, 5 or 6.
References Cited (Backward Citations)
US3459753A
Cited
US3996361A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-01-15 | 1988-07-16 | 1989-01-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-01-15 | 1992-07-16 | 1993-01-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-01-15 | 1996-07-16 | 1997-01-15 | $7700.00 | Window Closed / Lapsed |