US4490291A
Expired / Lapsed
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Nonapeptide amides
Assignee: Takeda Pharmaceutical Co Ltd
•
Filing: 1975-07-17
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Granted: 1984-12-25
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Expires: 1995-07-17
Abstract
Abstract The novel nonapeptide amide derivatives of the formula (Pyr)Glu-R1-Trp-Ser-R2-(D)-Ala-R3-Arg-Pro-NH-R4 wherein R1 is His, Tyr, Trp or p-NH2-Phe; R2 is Tyr or Phe; R3 is Leu, Ile or Nle and R4 is alkyl of 1 to 3 carbon atoms which may be substituted with hydroxyl group have a strong ovulation inducing activity.
Inventors
- 👤 Masahiko Fujino
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:07
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/04; C07K7/23; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/13
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
50 words
A compound of the formula (Pyr)Glu--R.sub.1 --Trp--Ser--R.sub.2 --(D)--Ala--R.sub.3 --Arg--Pro--NH--R.sub.4 wherein R 1 is His, Tyr, or p--NH 2 --Phe, R 2 is Tyr or Phe, R 3 is Leu, Ile or Nle and R 4 is alkyl of 1 to 3 carbon atoms which may be substituted therefor, by hydroxy.
Claim 2
Dependent Claim
50 words
A compound of the formula (Pyr)Glu--R.sub.1 --Trp--Ser--R.sub.2 --(D)--Ala--R.sub.3 --Arg--Pro--NH--R.sub.4 wherein R 1 is His, Tyr, or p--NH 2 --Phe, R 2 is Tyr or Phe, R 3 is Leu, Ile or Nle and R 4 is alkyl of 1 to 3 carbon atoms which may be substituted therefor, by hydroxy.
Claim 3
Dependent Claim
12 words
A compound as claimed in claim 1, wherein R 1 is His.
Claim 4
Dependent Claim
16 words
The compound as claimed in claim 1, wherein R 1 is Tyr or p--NH 2 --Phe.
Claim 5
Dependent Claim
12 words
The compound as claimed in claim 1, wherein R 2 is Tyr.
Claim 6
Dependent Claim
12 words
A compound as claimed in claim 1, wherein R 3 is Leu.
Claim 7
Dependent Claim
25 words
The compound as claimed in claim 1, wherein R 1 is His, R 2 is Tyr, R 3 is Leu and R 4 is ethyl.
Claim 8
Dependent Claim
25 words
The compound as claimed in claim 1, wherein R 1 is His, R 2 is Tyr, R 3 is Leu and R 4 is n-propyl.
Claim 9
Dependent Claim
25 words
The compound as claimed in claim 1, wherein R 1 is His, R 2 is Tyr, R 3 is Leu and R 4 is 2-hydroxyethyl.
Claim 10
Dependent Claim
25 words
The compound as claimed in claim 1, wherein R 1 is His, R 2 is Tyr, R 3 is Leu and R 4 is i-propyl.
Claim 11
Dependent Claim
25 words
The compound as claimed in claim 1, wherein R 1 is His, R 2 is Phe, R 3 is Leu and R 4 is ethyl.
Claim 12
Dependent Claim
26 words
The compound as claimed in claim 1, wherein R 1 is His, R 2 is Tyr, R 3 is Nle and R 4 is ethyl group.
Claim 13
Dependent Claim
26 words
The compound as claimed in claim 1, wherein R 1 is His, R 2 is Phe, R 3 is Ile and R 4 is ethyl group.
Claim 14
Dependent Claim
26 words
The compound as claimed in claim 1, wherein R 1 is Tyr, R 2 is Tyr, R 3 is Leu and R 4 is ethyl group.
Claim 15
Dependent Claim
27 words
The compound as claimed in claim 1, wherein R 1 is p--NH 2 --Phe, R 2 is Tyr, R 3 is Leu and R 4 is ethyl.
Claim 16
Dependent Claim
12 words
A compound as claimed in claim 1 wherein R 2 is Phe.
Claim 17
Dependent Claim
21 words
A compound as claimed in claim 1 wherein R 2 is Tyr and R 4 is alkyl of 3 carbon atoms.
Claim 18
Dependent Claim
21 words
A compound as claimed in claim 1 wherein R 2 is Tyr, and R 4 is --CH 2 CH 2 OH.
Claim 19
Dependent Claim
21 words
A compound of the formula (Pyr)Glu--His--Trp--Ser--Tyr--D--Ala--Leu--Arg--Pro--X wherein X is NHCH 2 CH 3 or NHCH 2 CH 2 CH 3 .
Claim 20
Dependent Claim
21 words
A compound of the formula (Pyr)Glu--His--Trp--Ser--Tyr--D--Ala--Leu--Arg--Pro--X wherein X is NHCH 2 CH 3 or NHCH 2 CH 2 CH 3 .
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-12-25 | 1988-06-25 | 1988-12-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-12-25 | 1992-06-25 | 1992-12-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-12-25 | 1996-06-25 | 1996-12-25 | $7700.00 | Window Closed / Lapsed |