US4487716A
Expired / Lapsed
US
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N-(1-Carboxy-3-phenylpropyl)-dipeptides
Assignee: Wyeth LLC
•
Filing: 1982-08-23
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Granted: 1984-12-11
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Expires: 2002-08-23
Abstract
Abstract The N-(1-carboxy-3-phenylpropyl)-dipeptides of the formula: ##STR1## inhibit angiotensin converting enzyme and serve as antihypertensive agents to reduce blood pressure in animals.
Inventors
- 👤 Dimitrios Sarantakis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 19:53
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/02; C07K5/022; C07K5/0222; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S530/00; Y10S530/80
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
78 words
A compound of the formula: ##STR6## in which R 1 is hydrogen or alkyl of 1 to 4 carbon atoms; R 2 is phenyl or substituted phenyl containing from one to two substituents selected from alkyl of 1 to 4 carbon atoms, halo, alkoxy of 1 to 4 carbon atoms, hydroxyl, nitro or amino; R 3 is hydrogen or alkyl of 1 to 4 carbon atoms; and n is the integer 4; or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
78 words
A compound of the formula: ##STR6## in which R 1 is hydrogen or alkyl of 1 to 4 carbon atoms; R 2 is phenyl or substituted phenyl containing from one to two substituents selected from alkyl of 1 to 4 carbon atoms, halo, alkoxy of 1 to 4 carbon atoms, hydroxyl, nitro or amino; R 3 is hydrogen or alkyl of 1 to 4 carbon atoms; and n is the integer 4; or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
9 words
The compound of claim 1 which is N.sup.α -(DL-1-carboxy-3-phenylpropyl)-L-Lysyl-N-phenylglycine.
Claim 4
Dependent Claim
9 words
The compound of claim 1 which is N.sup.α -(DL-1-carboxy-3-phenylpropyl)-L-lysyl-N-p-methoxyphenylglycine.
Claim 5
Dependent Claim
10 words
The compound of claim 1 which is N 2 -(DL-1-carboxy-3-phenylpropyl)-L-lysyl-N-(2,6-dimethylphenyl)glycine.
Claim 6
Dependent Claim
10 words
The compound of claim 1 which is N 2 -(DL-1-carboxy-3-phenylpropyl)-L-2,4-diamino-butyryl-N-p-aminophenyl)-L-alanine.
References Cited (Backward Citations)
EP0012401A1
Cited
GB2095682A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-12-11 | 1988-06-11 | 1988-12-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-12-11 | 1992-06-11 | 1992-12-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-12-11 | 1996-06-11 | 1996-12-11 | $7700.00 | Window Closed / Lapsed |