US4482251A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Clinical analyzer
Assignee: ELCTRO-NUCLEONICS Inc A CORP OF NJ
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Filing: 1981-10-19
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Granted: 1984-11-13
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Expires: 2001-10-19
Abstract
Abstract A clinical analyzer that is microprocessor controlled is disclosed. A shuttle carries a plurality of cuvettes containing liquids to be spectrophotometrically analyzed by a single beam spectrophotometer. The shuttle moves the cuvettes past the spectrophotometer in a plurality of cycles to complete a given test. At the beginning of a test, spectrophotometer lamp energization is controlled to achieve a predetermined spectrophotometer output for a reference filter. The remaining filters are then positioned one-by-one, and amplifier gain is adjusted to achieve optimum spectrophotometer output for each filter. The gain associated with each filter is stored by the microprocessor, and thereafter during the test, when each filter is used, the stored gain associated with that microprocessor is utilized in the amplifier circuitry. Additionally, at the beginning of each cycle of shuttle movement, an air calibration reading is taken, to be used by the microprocessor in determining absorbance. This air-only reading, in combination with a reference reading taken with a water-filled cuvette at any convenient time, serves to provide for accurate calibration of the system, overcoming problems of drift.
Inventors
- 👤 Richard Saylor
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 07:21
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/17; G01N21/25; G01N21/251; G01N21/253; G01N2201/00; G01N2201/04; G01N2201/0438; G01N2201/0484
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
114 words
In a clinical analyzer that includes a shuttle carrying a plurality of cuvettes containing liquid to be analyzed spectrophotometrically by a single beam spectrophotometer including a plurality of light filters, means for moving the shuttle past the spectrophotometer so that selected ones of said cuvettes are examined in a plurality of cycles of movement of each cuvette past the spectrophotometer to complete a test run, the improvement for calibrating the spectrophotometer circuitry comprising means for periodically completing a spectrophotometric reading of air only, including an attenuation circuit providing for varying signal attenuation to produce two air-only readings that together determine the slope of a calibration curve, and means for selectively activating said attenuation circuit.
Claim 2
Dependent Claim
114 words
In a clinical analyzer that includes a shuttle carrying a plurality of cuvettes containing liquid to be analyzed spectrophotometrically by a single beam spectrophotometer including a plurality of light filters, means for moving the shuttle past the spectrophotometer so that selected ones of said cuvettes are examined in a plurality of cycles of movement of each cuvette past the spectrophotometer to complete a test run, the improvement for calibrating the spectrophotometer circuitry comprising means for periodically completing a spectrophotometric reading of air only, including an attenuation circuit providing for varying signal attenuation to produce two air-only readings that together determine the slope of a calibration curve, and means for selectively activating said attenuation circuit.
Claim 3
Dependent Claim
25 words
A signal analyzer according to claim 1, in which said predetermined attenuation is generally about 3% representing an optical absorbance of about 1.5 absorbance units.
Claim 4
Dependent Claim
24 words
A clinical analyzer as in claim 1, in which said activating means activates said attenuation circuit at least once during said plurality of cycles.
Claim 5
Dependent Claim
96 words
A clinical analyzer as in claim 3, including a gain control and means active at least at the beginning of a test for completing a reference spectrophotometric reading of each of a plurality of said filters and adjusting said gain control for each filter to achieve a preselected spectrophotometric output, means for storing said gain adjustment for each filter, and means active thereafter during each cycle of testing during said test for adjusting said gain control so that it conforms to the value stored for a given filter when the filter is employed during said test.
Claim 6
Dependent Claim
31 words
A clinical analyzer according to claim 4, in which said gain control adjustment means comprises a plurality of analogue switches, various combinations of which are activated to provide for gain adjustment.
Claim 7
Dependent Claim
55 words
A clinical analyzer according to claim 5, in which said gain storing and gain adjustment means comprises a microprocessor for storing signals representing said various combinations of said analogue switches providing for said gain adjustment, and interface means coupled to said microprocessor and activating said analogue switches to produce said various combinations during a test.
Claim 8
Dependent Claim
28 words
A clinical analyzer as in claim 5, including means for completing a spectrophotometric reading of a cuvette to obtain a reading of a "clear" cuvette for reference purposes.
Claim 9
Dependent Claim
180 words
In a clinical analyzer that includes a shuttle carrying a plurality of cuvettes containing liquids to be analyzed past a spectrophotometer, said spectrophotometer having gain control and including a lamp and a filter assembly containing a plurality of light filters, and means for moving the shuttle past the spectrophotometer so that selected ones of said cuvettes are examined in a plurality of cycles of movement of each cuvette past the spectrophotometer so that a plurality of said cycles complete a test for a group of said cuvettes, the improvement for adaptively calibrating the spectrophotometer circuitry comprising means active at least at the beginning of each test for completing a reference spectrophotometric reading of each of a plurality of said filters and adjusting said gain control for each filter to achieve a preselected spectrophotometric output, means for storing said gain adjustment for each filter, and means active thereafter during each cycle of testing during said test for adjusting said gain control so that it conforms to the value stored for a given filter when that filter is employed during said test.
Claim 10
Dependent Claim
180 words
In a clinical analyzer that includes a shuttle carrying a plurality of cuvettes containing liquids to be analyzed past a spectrophotometer, said spectrophotometer having gain control and including a lamp and a filter assembly containing a plurality of light filters, and means for moving the shuttle past the spectrophotometer so that selected ones of said cuvettes are examined in a plurality of cycles of movement of each cuvette past the spectrophotometer so that a plurality of said cycles complete a test for a group of said cuvettes, the improvement for adaptively calibrating the spectrophotometer circuitry comprising means active at least at the beginning of each test for completing a reference spectrophotometric reading of each of a plurality of said filters and adjusting said gain control for each filter to achieve a preselected spectrophotometric output, means for storing said gain adjustment for each filter, and means active thereafter during each cycle of testing during said test for adjusting said gain control so that it conforms to the value stored for a given filter when that filter is employed during said test.
Claim 11
Dependent Claim
52 words
A clinical analyzer as in claim 8, in which said adjustment means includes means for first completing a reference spectrophotometric reading of a reference filter and adjusting the energization of said lamp to achieve a predetermined spectrophotometric output, and thereafter completing said spectrophotometric reading of said filters for said gain control adjustment.
Claim 12
Dependent Claim
31 words
A clinical analyzer according to claim 8, in which said gain control adjustment means comprises a plurality of analogue switches, various combinations of which are activated to provide for gain adjustment.
Claim 13
Dependent Claim
55 words
A clinical analyzer according to claim 10, in which said gain storing and gain adjustment means comprises a microprocessor for storing signals representing said various combinations of said analogue switches providing for said gain adjustment, and interface means coupled to said microprocessor and activating said analogue switches to produce said various combinations during a test.
Claim 14
Dependent Claim
134 words
In a system for process monitoring utilizing a source for engergizing a test instrument and detection circuitry coupled to the test instrument and including gain control in a plurality of test modalities, the improvement for adaptively calibrating said system comprising means periodically activated for controlling the energization of said source to an extent so that a predetermined output is achieved by said detection circuitry, means activating each of said modalities when said source is energized to said extent and adjusting said gain control so that the output of said detection circuitry achieves a preselected value, means for storing said gain adjustment for each of said modalities, and means active thereafter during process monitoring for adjusting said gain control to the value stored for a given modality when that modality is employed during process monitoring.
Claim 15
Dependent Claim
134 words
In a system for process monitoring utilizing a source for engergizing a test instrument and detection circuitry coupled to the test instrument and including gain control in a plurality of test modalities, the improvement for adaptively calibrating said system comprising means periodically activated for controlling the energization of said source to an extent so that a predetermined output is achieved by said detection circuitry, means activating each of said modalities when said source is energized to said extent and adjusting said gain control so that the output of said detection circuitry achieves a preselected value, means for storing said gain adjustment for each of said modalities, and means active thereafter during process monitoring for adjusting said gain control to the value stored for a given modality when that modality is employed during process monitoring.
References Cited (Backward Citations)
US28803A
Cited
US3580683A
Cited
US3703336A
Cited
USRE28803E
Cited
US3783300A
Cited
US4053235A
Cited
US3960497A
Cited
JPS5242188A
Cited
JPS5260692A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-11-13 | 1988-05-14 | 1988-11-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-11-13 | 1992-05-14 | 1992-11-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-11-13 | 1996-05-14 | 1996-11-13 | $7700.00 | Window Closed / Lapsed |