US4478827A
Expired / Lapsed
US
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Renin inhibitors
Assignee: General Hospital Corp
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Filing: 1983-05-09
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Granted: 1984-10-23
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Expires: 2003-05-09
Abstract
Abstract A compound of the formula Z-His-Pro-Phe-His-X-X-Val-Tyr-(D-)-Y wherein the Xs are the same or different and selected from the group consisting of an aromatic, a chlorinated aromatic, an aliphatic and a chlorinated aliphatic amino acid residue; Y is a positively or negatively charged amino acid residue; and Z is a proline or a polyprolyl residue having up to 5 prolyl residues, is useful for decreasing renin-related high blood pressure.
Inventors
- 👤 Edgar Haber
- 👤 James Burton
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 14:40
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/04; C07K7/14; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S530/00; Y10S530/80; Y10S530/86
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
87 words
A compound of the formula Z-His-Pro-Phe-His-X-X-Val-Tyr-(D-)-Y wherein the X's are the same or different and selected from the group consisting of aromatic, an aliphatic and a chlorinated aliphatic amino acid phenylalanine, tyrosine, mono-chloro phenylalanine, leucine, isoleucine, valine and glycine; Y is selected from the group consisting of lysine, arginine, ornithine, aspartic acid, glutamic acid, and their alpha-carbon esters of lower aliphatic alcohols, and alpha-carbon primary or secondary lower aliphatic amides; and Z is a proline, hydroxyproline, thioproline or a polyproline residue having up to 5 prolyl residues.
Claim 2
Dependent Claim
87 words
A compound of the formula Z-His-Pro-Phe-His-X-X-Val-Tyr-(D-)-Y wherein the X's are the same or different and selected from the group consisting of aromatic, an aliphatic and a chlorinated aliphatic amino acid phenylalanine, tyrosine, mono-chloro phenylalanine, leucine, isoleucine, valine and glycine; Y is selected from the group consisting of lysine, arginine, ornithine, aspartic acid, glutamic acid, and their alpha-carbon esters of lower aliphatic alcohols, and alpha-carbon primary or secondary lower aliphatic amides; and Z is a proline, hydroxyproline, thioproline or a polyproline residue having up to 5 prolyl residues.
Claim 3
Dependent Claim
17 words
The compound of claim 1 wherein both Xs are phenylalanyl, Z is proline and Y is lysine.
Claim 4
Dependent Claim
35 words
A process for reducing blood pressure in an animal afflicted with high blood pressure related to renin excess, which comprises administering to said animal a blood pressure decreasing amount of a compound of claim 1.
Claim 5
Dependent Claim
22 words
The process of claim 3 wherein said compound is such that the Xs are phenylalanyl, Z is prolyl and Y is lysyl.
Claim 6
Dependent Claim
11 words
The process of claim 3 wherein said animal is a human.
Claim 7
Dependent Claim
34 words
A composition useful for reducing blood pressure related to renin in animals which comprises a blood pressure decreasing amount of a compound of the formula of claim 1, together with a pharmaceutically inert carrier.
References Cited (Backward Citations)
US4269827A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-10-23 | 1988-04-23 | 1988-10-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-10-23 | 1992-04-23 | 1992-10-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-10-23 | 1996-04-23 | 1996-10-23 | $7700.00 | Window Closed / Lapsed |