US4477469A
Expired / Lapsed
US
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Preparations containing methylsulfonylmethane and methods of use and purification
Assignee: Individual
•
Filing: 1981-06-26
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Granted: 1984-10-16
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Expires: 2001-06-26
Abstract
Abstract Preparations containing methylsulfonylmethane (MSM) for administration to the skin, nails, other tissue and/or body fluids of a human or other animal subject are disclosed. Such compositions soften skin, strengthen nails and provide other benefits when applied topically. And, MSM compositions may also be administered orally, by injection and by inhalation. In many instances, the effectiveness of MSM compositions is enhanced when such compositions contain carbamide (urea). Also, carbamide compositions are stabilized when they contain the MSM. For topical administration, MSM compositions may be formulated in creams, lotions or gels which may be used alone or to serve as stable, neutral vehicles for other skin conditioning substances or therapeutically active drugs. Aqueous MSM solutions are suitable blood diluents.
Inventors
- 👤 Robert J. Herschler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 00:32
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/16; A61K31/17; A61K31/095; A61K31/10; A61K31/70; A61K31/7004; A61K33/00; A61K33/14; A61K8/00; A61K8/18; A61K8/30; A61K8/46; A61Q; A61Q19/00; A61Q3/00; A61K2800/00; A61K2800/74; A61K2800/75; A61Q17/00; A61Q17/02; A61Q3/02; A61Q5/00; A61Q5/006; A61Q5/02; A61Q5/06
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
54 words
A composition suitable for application to tissue and/or body fluids of a human or other animal subject comprising a pharmaceutically acceptable composition containing about one to twenty weight percent methylsulfonylmethane as an essential active agent, and an amount from about one to twenty weight percent carbamide effective to enhance the activity of the methylsulfonylmethane.
Claim 2
Dependent Claim
54 words
A composition suitable for application to tissue and/or body fluids of a human or other animal subject comprising a pharmaceutically acceptable composition containing about one to twenty weight percent methylsulfonylmethane as an essential active agent, and an amount from about one to twenty weight percent carbamide effective to enhance the activity of the methylsulfonylmethane.
Claim 3
Dependent Claim
19 words
A composition as in claim 1 adapted for topical application and containing up to about fifteen weight percent carbamide.
Claim 4
Dependent Claim
14 words
A composition as in claim 2 comprising at least about five weight percent carbamide.
Claim 5
Dependent Claim
24 words
A composition as in claim 2 comprising: about 2 to about 10 weight percent methylsulfonylmethane, and about 2 to about 10 weight percent carbamide.
Claim 6
Dependent Claim
21 words
A composition as in claim 4 wherein the composition is a viscous liquid of the group including creams, lotions and gels.
Claim 7
Dependent Claim
13 words
A composition as in claim 5 wherein the composition is an injectable solution.
Claim 8
Dependent Claim
12 words
A composition as in claim 4 comprising methylsulfonylmethane in a gaseous medium.
Claim 9
Dependent Claim
14 words
A composition as in claim 1 further comprising up to thirty weight percent DMSO.
Claim 10
Dependent Claim
98 words
A composition for topical application to the skin of a human or other animal subject comprising an aqueous solution of one to ten weight percent each of methylsulfonylmethane and carbamide in a combined amount such that the composition is capable of eliciting a physiological effect upon application of the composition, the ratio of methylsulfonylmethane to carbamide being such that the extent of the physiological effect is greater than the extent of the effect which results from application of an otherwise identical composition containing only one of said methylsulfonylmethane and carbamide in an amount equal to said combined amount.
Claim 11
Dependent Claim
98 words
A composition for topical application to the skin of a human or other animal subject comprising an aqueous solution of one to ten weight percent each of methylsulfonylmethane and carbamide in a combined amount such that the composition is capable of eliciting a physiological effect upon application of the composition, the ratio of methylsulfonylmethane to carbamide being such that the extent of the physiological effect is greater than the extent of the effect which results from application of an otherwise identical composition containing only one of said methylsulfonylmethane and carbamide in an amount equal to said combined amount.
Claim 12
Dependent Claim
17 words
In a chemical composition containing carbamide, an amount of methylsulfonylmethane effective to retard decomposition of the carbamide.
Claim 13
Dependent Claim
17 words
In a chemical composition containing carbamide, an amount of methylsulfonylmethane effective to retard decomposition of the carbamide.
Claim 14
Independent Claim
53 words
A method for altering the condition of tissue and/or body fluids of a human or other animal subject comprising concurrently topically administering to the subject one to twenty weight percent methylsulfonylmethane and an amount of carbamide in the range of one to twenty weight percent effective to enhance the activity of the methylsulfonylmethane.
Claim 15
Independent Claim
53 words
A method for altering the condition of tissue and/or body fluids of a human or other animal subject comprising concurrently topically administering to the subject one to twenty weight percent methylsulfonylmethane and an amount of carbamide in the range of one to twenty weight percent effective to enhance the activity of the methylsulfonylmethane.
Claim 16
Dependent Claim
18 words
A method as in claim 11 wherein the carbamide is administered in a composition which includes the methylsulfonylmethane.
Claim 17
Dependent Claim
25 words
A method as in claim 11 wherein the carbamide is administered to the subject in a composition containing at least about five weight percent carbamide.
Claim 18
Dependent Claim
29 words
A method as in claim 11 wherein the methane and carbamide are administered to skin of the subject in an amount effective to enhance moisture retention of the skin.
Claim 19
Dependent Claim
35 words
A method as in claim 11 wherein the methane and carbamide are administered to skin of a subject suffering from irritation of the skin in an amount sufficient to relieve discomfort resulting from the irritation.
Claim 20
Dependent Claim
26 words
A method as in claim 11 wherein the methane and carbamide are administered to skin of the subject in an amount effective to soften the skin.
Claim 21
Dependent Claim
29 words
A method as in claim 11 wherein the methane and carbamide are administered to skin of the subject in an amount effective to increase the smoothness of the skin.
Claim 22
Dependent Claim
29 words
A method as in claim 11 wherein the methane and carbamide are administered to skin of the subject in an amount effective to preserve the pliancy of the skin.
Claim 23
Dependent Claim
40 words
A method as in claim 11 wherein the methane and carbamide are administered to skin of the subject, prior to shaving the skin with a razor blade, in an amount effective to reduce the drag of the razor during shaving.
Claim 24
Dependent Claim
19 words
A method as in claim 11 wherein the methane and carbamide are administered to connective tissue of the subject.
Claim 25
Dependent Claim
40 words
A method for treating finger and/or toe nails of a human or other animal subject comprising topically administering to the nails of the subject, an amount of a composition of claim 4 to effectively reduce the brittleness of the nails.
Claim 26
Dependent Claim
46 words
A method for removing cuticle from the finger and/or toe nails of a human or other animal subject, comprising topically administration to the cuticle, a composition of claim 4 in an amount effective to soften the cuticle so that it can be removed by gentle rubbing.
Claim 27
Dependent Claim
31 words
A method as in claim 12 wherein the methylsulfonylmethane and carbamide are administered as a pharmaceutically acceptable composition adapted for topical administration and containing up to 15 weight percent of methylsulfonylmethane.
Claim 28
Dependent Claim
23 words
A method as in claim 12 wherein the composition administered contains about 1 to about 10 weight percent each of methylsulfonylmethane and carbamide.
Claim 29
Dependent Claim
18 words
A method as in claim 12 wherein the composition administered also contains up to 30 weight percent dimethylsulfoxide.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-10-16 | 1988-04-16 | 1988-10-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-10-16 | 1992-04-16 | 1992-10-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-10-16 | 1996-04-16 | 1996-10-16 | $7700.00 | Window Closed / Lapsed |