US4477435A
Expired / Lapsed
US
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Method for regenerating corneal epithelium
Assignee: Institut National de la Santé et de la Recherche Médicale
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Filing: 1982-09-30
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Granted: 1984-10-16
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Expires: 2002-09-30
Abstract
Abstract A composition and a method for regenerating wounded or damaged corneal epithelium are described. The composition comprises an aqueous solution containing an effective amount of ocular extract RE. The RE is extracted from eye tissues, such as choroid, iris and vitreous as well as aqueous humor. The active extract is obtained by the treatment of bovine ocular tissues with a buffered aqueous saline solution at pH of about 7.2. For ophthalmological use, the RE extract is purified by precipitation with acetic acid and dialyzed against physiologic saline NaCl solution. Such a composition is shown to increase significantly the rate of healing of wounded corneal epithelium.
Inventors
- 👤 Yves Courtois
- 👤 Denis Barritault
- 👤 Yves Pouliquen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 02:41
CPC Classifications
A; A61; A61K; A61K35/00; A61K35/12; A61K35/44
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
31 words
A method for regenerating wounded or damaged corneal epithelium, comprising the step of: contacting said epithelium in vivo with a therapeutically effective amount of an aqueous salt extract of ocular tissue.
Claim 2
Independent Claim
31 words
A method for regenerating wounded or damaged corneal epithelium, comprising the step of: contacting said epithelium in vivo with a therapeutically effective amount of an aqueous salt extract of ocular tissue.
Claim 3
Dependent Claim
37 words
The method of claim 1, wherein said extract is obtained by extracting an eye tissue selected from the group consisting of retinal tissue, choroid tissue, iris tissue, vitreous humor and aqueous humor with an aqueous salt solution.
Claim 4
Dependent Claim
46 words
The method of claim 1, wherein said extract is obtained by extracting bovine ocular tissues with a buffered aqueous saline solution having a pH of about 7.2, purifying said extract by treatment with acetic acid, and dialyzing said treated extract against a physiologic saline NaCl solution.
Claim 5
Dependent Claim
22 words
The method of claim 1 or 3, wherein the amount of said extract applied ranges from 10 μg/ml to about 1 mg/ml.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-10-16 | 1988-04-16 | 1988-10-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-10-16 | 1992-04-16 | 1992-10-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-10-16 | 1996-04-16 | 1996-10-16 | $7700.00 | Window Closed / Lapsed |