US4473555A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Nona- and dodecapeptides for augmenting natural killer cell activity
Assignee: Syntex USA LLC
•
Filing: 1983-10-17
•
Granted: 1984-09-25
•
Expires: 2003-10-17
Abstract
Abstract The abstract is disclosed herein are nonapeptides and dodecapeptides which augment natural killer cell activity.
Inventors
- 👤 John J. Nestor, Jr.
- 👤 John G. Moffatt
- 👤 John M. Sims
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 20:32
CPC Classifications
C; C07; C07C; C07C7/00; C07C7/04; C07C7/05; C07C7/06; C07K; C07K14/00; C07K14/435; C07K14/52; C07K14/555; C07K14/57; A; A61; A61P; A61P37/00; A61K; A61K38/00
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
42 words
A compound of the formula X-Asp-Pro-Tyr-Val-Lys-Glu-Ala-Y (I) wherein X is N-acyl-Gln, or N-acyl-Cys-Tyr-Cys-Gln- and Y is Gly, Glu, GlyN(R) 2 or GluN(R) 2 wherein R is hydrogen or alkyl of 1 to 6 carbon atoms and the pharmaceutically acceptable, non-toxic salts thereof.
Claim 2
Dependent Claim
42 words
A compound of the formula X-Asp-Pro-Tyr-Val-Lys-Glu-Ala-Y (I) wherein X is N-acyl-Gln, or N-acyl-Cys-Tyr-Cys-Gln- and Y is Gly, Glu, GlyN(R) 2 or GluN(R) 2 wherein R is hydrogen or alkyl of 1 to 6 carbon atoms and the pharmaceutically acceptable, non-toxic salts thereof.
Claim 3
Dependent Claim
23 words
A compound of claim 1 wherein X is a N-Ac-Gln and Y is Gly, namely N-Ac-L-Gln-L-Asp-L-Pro-L-Tyr-L-Val-L-Lys-L-Glu-L-Ala-Gly and the pharmaceutically acceptable non-toxic salts thereof.
Claim 4
Dependent Claim
22 words
A compound of claim 1 wherein X is N-Ac-Gln and Y is L-Glu, namely N-Ac-L-Gln-L-Asp-L-Pro-L-Tyr-L-Val-L-Lys-L-Glu-L-Ala-L-Glu and the pharmaceutically acceptable non-toxic salts thereof.
Claim 5
Dependent Claim
22 words
A compound of claim 1 wherein X is N-Ac-L-Cys-L-Tyr-L-Cys-L-Gln and Y is Gly, namely N-Ac-L-Cys-L-Tyr-L-Cys-L-Gln-L-Asp-L-Pro-L-Tyr-L-Val-L-Lys-L-Glu-L-Ala-Gly and the pharmaceutically acceptable non-toxic salts thereof.
Claim 6
Dependent Claim
22 words
A compound of claim 1 wherein X is N-Ac-L-Cys-L-Tyr-L-Cys-L-Gln and Y is Glu, namely N-Ac-L-Cys-L-Tyr-L-Cys-L-Gln-L-Asp-L-Pro-L-Tyr-L-Val-L-Lys-L-Glu-L-Ala-L-Gln and the pharmaceutically acceptable non-toxic salts thereof.
Claim 7
Dependent Claim
28 words
A pharmaceutical composition for augmenting natural killer cell activity comprising an effective amount of a compound of claim 1 in admixture with at least one pharmaceutically acceptable excipient.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-09-25 | 1988-03-26 | 1988-09-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-09-25 | 1992-03-26 | 1992-09-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-09-25 | 1996-03-26 | 1996-09-25 | $7700.00 | Window Closed / Lapsed |