US4472579A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for the preparation of quinoline carboxylic acid derivatives
Assignee: Kyorin Pharmaceutical Co Ltd
•
Filing: 1981-08-31
•
Granted: 1984-09-18
•
Expires: 2001-08-31
Abstract
Abstract Process for the preparation of useful antimicorbial agents, 1-substituted-6-fluoro-7-(1-piperazinyl or 4-substituted-1-piperazinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acids having the chemical structure [IV], <IMAGE> [IV] wherein R1 is ethyl or vinyl group, and R4 is <IMAGE> (R3 is hydrogen atom or lower alkyl group).
Inventors
- 👤 Tsutomu Irikura
- 👤 Toshie Shiba
- 👤 Hiroshi Matsukubo
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 14:05
CPC Classifications
C; C07; C07D; C07D215/00; C07D215/02; C07D215/16; C07D215/48; C07D215/54; C07D215/56
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
115 words
A process for the preparation of 1-substituted-6-fluoro-7-(1-piperazinyl or 4-substituted 1-piperazinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid having the structural formula (IV) ##STR17## wherein R 1 and R 2 are defined as hereinafter, consisting essentially of reacting a 1-substituted-6-fluoro-7-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ester derivative having the structural formula ##STR18## wherein R 1 is an ethyl or vinyl group, R 2 is a lower alkyl group, with a piperazine derivative having the structural formula (II) ##STR19## wherein R 3 is hydrogen atom or lower alkyl group, to produce a compound having the structural formula (III), ##STR20## wherein R 4 is ##STR21## and R 1 , R 2 , and R 3 are defined as above, and then hydrolyzing the compound having structural formula (III).
Claim 2
Dependent Claim
115 words
A process for the preparation of 1-substituted-6-fluoro-7-(1-piperazinyl or 4-substituted 1-piperazinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid having the structural formula (IV) ##STR17## wherein R 1 and R 2 are defined as hereinafter, consisting essentially of reacting a 1-substituted-6-fluoro-7-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ester derivative having the structural formula ##STR18## wherein R 1 is an ethyl or vinyl group, R 2 is a lower alkyl group, with a piperazine derivative having the structural formula (II) ##STR19## wherein R 3 is hydrogen atom or lower alkyl group, to produce a compound having the structural formula (III), ##STR20## wherein R 4 is ##STR21## and R 1 , R 2 , and R 3 are defined as above, and then hydrolyzing the compound having structural formula (III).
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-09-18 | 1988-03-19 | 1988-09-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-09-18 | 1992-03-19 | 1992-09-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-09-18 | 1996-03-19 | 1996-09-18 | $7700.00 | Window Closed / Lapsed |