US4472406A
Expired / Lapsed
US
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Antimicrobial 6,7-dihydro-8-(imidazol-1-yl)-5-methyl-1-oxo-1H,5H-benzo [ij]quinolizine-2-carboxylic acids and derivatives
Assignee: Riker Laboratories Inc
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Filing: 1982-11-12
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Granted: 1984-09-18
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Expires: 2002-11-12
Abstract
Abstract Certain 6,7-dihydro-8-(imidazol-1-yl)-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acids are disclosed as potent antimicrobial agents with an unusual spectrum of activity. Esters, acyl chlorides, alkylaminoalkyl ester salts, salts of a nitrogen atom of the imidazole ring, and pharmaceutically acceptable carboxylate salts are also disclosed. Novel synthetic intermediates are also described.
Inventors
- 👤 John F. Gerster
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 06:25
CPC Classifications
C; C07; C07D; C07D471/00; C07D471/02; C07D471/04; C07D231/00; C07D231/02; C07D231/10; C07D231/12; A; A61; A61P; A61P31/00; A61P31/04; C07D215/00; C07D215/02; C07D215/16; C07D215/38; C07D233/00; C07D233/54; C07D233/56; C07D249/00; C07D249/02; C07D249/08; C07D455/00; C07D455/03; C07D455/04
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
87 words
A compound of the formula ##STR5## wherein X is hydrogen or halogen selected from fluorine, chlorine or bromine; or a derivative selected from the group consisting of an alkyl ester containing 1 to 4 carbon atoms in the alkyl group, the acyl chloride, an alkylaminoalkyl ester containing 1 to 4 carbon atoms in the alkyl groups, an alkylaminoalkyl ester salt containing 1 to 4 carbon atoms in the alkyl groups, a salt involving a nitrogen atom of the imidazole ring, and a pharmaceutically acceptable carboxylate salt thereof.
Claim 2
Dependent Claim
87 words
A compound of the formula ##STR5## wherein X is hydrogen or halogen selected from fluorine, chlorine or bromine; or a derivative selected from the group consisting of an alkyl ester containing 1 to 4 carbon atoms in the alkyl group, the acyl chloride, an alkylaminoalkyl ester containing 1 to 4 carbon atoms in the alkyl groups, an alkylaminoalkyl ester salt containing 1 to 4 carbon atoms in the alkyl groups, a salt involving a nitrogen atom of the imidazole ring, and a pharmaceutically acceptable carboxylate salt thereof.
Claim 3
Dependent Claim
21 words
A compound according to claim 1 which is a carboxylate salt selected from an alkali metal and alkaline earth carboxylate salts.
Claim 4
Dependent Claim
12 words
The compound 6,7-dihydro-8-(imidazol-1-yl)-9-fluoro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid or a salt thereof according to claim 1.
Claim 5
Dependent Claim
19 words
An antimicrobial composition comprising an effective amount of a compound according to claim 1 and a pharmaceutically acceptable carrier.
Claim 6
Dependent Claim
23 words
A method of inhibiting the growth of bacteria, comprising contacting said bacteria with an effective amount of a compound according to claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-09-18 | 1988-03-19 | 1988-09-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-09-18 | 1992-03-19 | 1992-09-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-09-18 | 1996-03-19 | 1996-09-18 | $7700.00 | Window Closed / Lapsed |