US4470981A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Chemical compounds
Assignee: Individual
•
Filing: 1982-12-20
•
Granted: 1984-09-11
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Expires: 2002-12-20
Abstract
Abstract The invention provides a compound of formula I ##STR1## where R 1 represents hydrogen, lower alkanoyl or aryol, or tri-lower alkyl silyl, or a group R 3 --O--CO-- (where R 3 represents lower alkyl); R 2 represents hydrogen, hydroxyl or fluorine and X represents --S--, --SO--, --SO 2 --, --O--or --NR 4 -- (where R 4 represents hydrogen, lower alkyl or lower alkanoyl); the compounds are useful in the prophylaxis or management of cardiovascular disease through the regulation of serum cholesterol and a particularly useful compound is 23-thia-25-hydroxy-cholesterol.
Inventors
- 👤 Robert H. Hesse
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 01:05
CPC Classifications
C; C07; C07J; C07J53/00; C07C; C07C323/00; C07J31/00; C07J31/006; C07J9/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
61 words
A compound of formula I ##STR6## where R 1 represents hydrogen, lower alkanoyl or aryol, or tri-lower alkyl silyl, or a group R 3 --O--CO-- (where R 3 represents lower alkyl); R 2 represents hydrogen, hydroxyl or fluorine and X repreesents --S--; --SO--, --SO 2 --, --O-- or --NR 4 -- (where R 4 represents hydrogen, lower alkyl or lower alkanoyl).
Claim 2
Dependent Claim
61 words
A compound of formula I ##STR6## where R 1 represents hydrogen, lower alkanoyl or aryol, or tri-lower alkyl silyl, or a group R 3 --O--CO-- (where R 3 represents lower alkyl); R 2 represents hydrogen, hydroxyl or fluorine and X repreesents --S--; --SO--, --SO 2 --, --O-- or --NR 4 -- (where R 4 represents hydrogen, lower alkyl or lower alkanoyl).
Claim 3
Dependent Claim
18 words
A compound as claimed in claim 1 wherein X is either --S--, or --SO-- or --SO 2 --.
Claim 4
Dependent Claim
26 words
A compound as claimed in claim 1 wherein X is either --S--, or --SO--, or --SO 2 -- and R 2 is either hydrogen or hydroxyl.
Claim 5
Dependent Claim
11 words
A compound as claimed in claim 1 wherein X is --S--.
Claim 6
Dependent Claim
16 words
A compound as claimed in claim 1 wherein X is --S-- and R 2 is hydroxyl.
Claim 7
Dependent Claim
25 words
A composition comprising a compound of claim 1 in sufficient amount to lower serum cholesterol together with one or more inert and acceptable pharmaceutical excipients.
Claim 8
Dependent Claim
30 words
A method of lowering serum cholesterol comprising administration of a compound of claim 1 in an amount sufficient to accomplish said reduction together with any pharmaceutically acceptable vehicle or excipient.
Claim 9
Dependent Claim
30 words
A method for lowering serum cholesterol comprising administration of a compound of claim 1 at a dose of 0.02 to 20 mg/kg. together with a pharmaceutically acceptable vehicle or excipient.
References Cited (Backward Citations)
US4215045A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-09-11 | 1988-03-12 | 1988-09-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-09-11 | 1992-03-12 | 1992-09-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-09-11 | 1996-03-12 | 1996-09-11 | $7700.00 | Window Closed / Lapsed |