US4469684A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Storage stable topical pharmaceutical composition containing zinc erythromycin and low dielectric solvents
Assignee: Procter and Gamble Co
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Filing: 1982-10-15
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Granted: 1984-09-04
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Expires: 2002-10-15
Abstract
Abstract A storage stable topical pharmaceutical composition containing zinc erythromycin, particularly useful in the topical treatment of acne vulgaris, is disclosed. This composition contains a solvent having a dielectric constant, measured at 25 DEG C., of from about 5.5 to about 15, preferably from about 8 to about 12, such as t-butanol, to impart storage stability to the zinc erythromycin component. The composition may additionally contain particularly selected pharmaceutically-acceptable nitrogen-containing stabilizer components, such as diisopropanolamine.
Inventors
- 👤 James E. Huggins
- 👤 Mary L. Batt
- 👤 William J. Kozarek
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 15:27
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K47/00; A61K47/06; A61K47/08; A61K47/10; A61K47/16; A61K47/18; A61K9/00; A61K9/0012; A61K9/0014; A61P; A61P17/00; A61P31/00; A61P31/04
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
56 words
A stable topical pharmaceutical composition comprising: (a) a safe and effective amount of zinc erythromycin comprising a mixture of a toxicologically-acceptable zinc salt and an erythromycin compound selected from the group consisting of erythromycin base, salts of erythromycin base with acids, and ester derivatives of erythromycin; and (b) from about 50% to about 99% of t-butanol.
Claim 2
Dependent Claim
56 words
A stable topical pharmaceutical composition comprising: (a) a safe and effective amount of zinc erythromycin comprising a mixture of a toxicologically-acceptable zinc salt and an erythromycin compound selected from the group consisting of erythromycin base, salts of erythromycin base with acids, and ester derivatives of erythromycin; and (b) from about 50% to about 99% of t-butanol.
Claim 3
Dependent Claim
17 words
A composition according to claim 1 which contains from about 0.3% to about 15% of component (a).
Claim 4
Dependent Claim
16 words
A composition according to claim 2 having a pH of from about 7 to about 10.
Claim 5
Dependent Claim
16 words
A composition according to claim 3 which contains from about 55% to about 80% of t-butanol.
Claim 6
Dependent Claim
45 words
A composition according to claim 3 which additionally contains from about 0.1% to about 10% of a pharmaceutically-acceptable stabilizer selected from the group consisting of diisopropanolamine, monoethanolamine, 2-amino-2-methyl-1-propanol, diethylamine, N,N-dimethylethanolamine, triethylamine, triethanolamine, cetyl pyridinium chloride, C 20 ammonium hexanoate, 1-dimethylamino-2-propanol, 3-dimethylamino-1-propanol, lecithin, and mixtures thereof.
Claim 7
Dependent Claim
18 words
A composition according to claim 5 which contains from about 0.5% to about 5% of the stabilizer component.
Claim 8
Dependent Claim
12 words
A composition according to claim 6 wherein the stabilizer component is diisopropanolamine.
Claim 9
Dependent Claim
19 words
A composition according to claim 6 which additionally contains from about 1% to about 45% of a pharmaceutically-acceptable cosolvent.
Claim 10
Dependent Claim
17 words
A composition according to claim 8 which contains from about 15% to about 35% of said cosolvent.
Claim 11
Dependent Claim
12 words
A composition according to claim 9 wherein the stabilizer component is diisopropanolamine.
Claim 12
Dependent Claim
12 words
A composition according to claim 10 wherein the cosolvent is diisopropyl sebacate.
Claim 13
Dependent Claim
18 words
A composition according to claim 11 wherein component is the reaction product of erythromycin base and zinc acetate.
References Cited (Backward Citations)
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US3472931A
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US3927197A
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US4006218A
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US4000263A
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FR2383667A1
Cited
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-09-04 | 1988-03-05 | 1988-09-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-09-04 | 1992-03-05 | 1992-09-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-09-04 | 1996-03-05 | 1996-09-04 | $7700.00 | Window Closed / Lapsed |