US4469228A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Interferon kit
Assignee: Merck Sharp & Dohme LLC
•
Filing: 1983-05-31
•
Granted: 1984-09-04
•
Expires: 2003-05-31
Abstract
Abstract Disclosed is a kit for preparing a lyophilized alpha interferon gel formulation suitable for topical administration.
Inventors
- 👤 Michael A. Zupon
- 👤 Joel A. Sequeira
- 👤 Alan S. Kirschner
- 👤 Pui-Ho Yuen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 08:27
CPC Classifications
B; B65; B65D; B65D81/00; B65D81/32; A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/19; A61K38/21; A61K38/212; A61K47/00; A61K47/06; A61K47/08; A61K47/10; A61K9/00; A61K9/0012; A61K9/0014; Y; Y10; Y10S; Y10S435/00; Y10S435/811
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
113 words
A kit for formulating and dispensing an alpha type interferon gel composition comprising (a) a vial having an open end aseptically sealed and containing about 1×10 4 to 5×10 8 International Units of lyophilized alpha type interferon formulation prepared from an alpha type interferon having a specific activity of at least 5×10 7 International Units/mg total protein; (b) and a tube with flexible walls having a sealed open end containing a dermotologically acceptable vehicle which contains a compatible preservative and a sufficient amount of polyoxyethylene polyoxypropylene block polymer for the vehicle to be liquid at 15° C. or below and which together with the lyophilized alpha interferon gels at 15° C. and above.
Claim 2
Dependent Claim
113 words
A kit for formulating and dispensing an alpha type interferon gel composition comprising (a) a vial having an open end aseptically sealed and containing about 1×10 4 to 5×10 8 International Units of lyophilized alpha type interferon formulation prepared from an alpha type interferon having a specific activity of at least 5×10 7 International Units/mg total protein; (b) and a tube with flexible walls having a sealed open end containing a dermotologically acceptable vehicle which contains a compatible preservative and a sufficient amount of polyoxyethylene polyoxypropylene block polymer for the vehicle to be liquid at 15° C. or below and which together with the lyophilized alpha interferon gels at 15° C. and above.
Claim 3
Dependent Claim
14 words
A kit according to claim 1 wherein the lyophilized alpha interferon is alpha-2 interferon.
Claim 4
Dependent Claim
19 words
A kit according to claim 2 wherein the compatible preservative employed in the dermatologically acceptable vehicle is benzyl alcohol.
Claim 5
Dependent Claim
30 words
A kit according to claim 1 wherein the dermatologically acceptable vehicle additionally contains a compatible buffer system to maintain the pH of the composition from pH 2 to pH 7.
Claim 6
Dependent Claim
16 words
A kit according to claim 4 wherein the compatible buffer sytem is phosphoric acid/monobasic sodium phosphate.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-09-04 | 1988-03-05 | 1988-09-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-09-04 | 1992-03-05 | 1992-09-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-09-04 | 1996-03-05 | 1996-09-04 | $7700.00 | Window Closed / Lapsed |