US4468384A
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Method for the inhibition of the replication of DNA viruses with 5-substituted 2-pyrimidinone nucleosides
Assignee: Research Foundation of the State University of New York
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Filing: 1982-01-05
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Granted: 1984-08-28
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Expires: 2002-01-05
Abstract
Abstract A method for inhibiting the replication of a DNA virus which induces formation of thymidine kinase enzyme, by exposing the virus to an effective concentration of a compound of the formula: <IMAGE> wherein R1 is a radical selected from the group consisting of halogen, -SCH3, -OH, alkoxy, cyano, methylamino, carboxy, formyl, nitro and unsubstituted or halosubstituted hydrocarbon groups of 1 through 3 carbon atoms; R2 is hydrogen; halogen or hydroxy; and R3 is hydroxy, -OP(O)(OH)2, amino, or -OOR4 where R4 is lower alkyl of 1 through 6 carbon atoms.
Inventors
- 👤 Thomas J. Bardos
- 👤 Yung-Chi Cheng
- 👤 Alan C. Schroeder
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 21:45
CPC Classifications
C; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/06
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
100 words
A method for inhibiting the replication of a DNA virus which induces formation of thymidine kinase enzyme, by exposing a susceptible DNA virus to an effective concentration of a compound of the formula: ##STR6## Wherein R 1 is a radical selected from the group consisting of halogen, --SCH 3 , --OH, alkoxy, cyano, methylamino, carboxy, formyl, nitro and unsubstituted or halosubstituted hydrocarbon groups of 1 through 3 carbon atoms; R 2 is hydrogen; halogen or hydroxy; and R 3 is hydroxy, --OP(O)(OH) 2 , amino, or --OOR 4 where R 4 is lower alkyl of 1 through 6 carbon atoms.
Claim 2
Independent Claim
100 words
A method for inhibiting the replication of a DNA virus which induces formation of thymidine kinase enzyme, by exposing a susceptible DNA virus to an effective concentration of a compound of the formula: ##STR6## Wherein R 1 is a radical selected from the group consisting of halogen, --SCH 3 , --OH, alkoxy, cyano, methylamino, carboxy, formyl, nitro and unsubstituted or halosubstituted hydrocarbon groups of 1 through 3 carbon atoms; R 2 is hydrogen; halogen or hydroxy; and R 3 is hydroxy, --OP(O)(OH) 2 , amino, or --OOR 4 where R 4 is lower alkyl of 1 through 6 carbon atoms.
Claim 3
Dependent Claim
40 words
The method of claim 1 wherein R 1 is a halogen, cyano, formyl, nitro, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl or haloalkynyl group of 1 through 3 carbon atoms; R 2 is hydrogen, fluorine or hydroxy and R 3 is hydroxy.
Claim 4
Dependent Claim
15 words
The method of claim 1 wherein the effective concentration is between 25 and 50 micromolar.
Claim 5
Dependent Claim
41 words
The method of claim 1 wherein the susceptible DNA virus is located in a warm blooded animal and the effective concentration is obtained in administering from 25 to 1000 milligrams of the compound per kilogram of body weight of the animal.
Claim 6
Dependent Claim
19 words
The method of claim 1 wherein R 1 is methyl; R 2 is hydrogen and R 3 is hydroxy.
Claim 7
Dependent Claim
14 words
The method of claim 1 wherein the susceptible DNA virus is a Herpes virus.
Claim 8
Dependent Claim
21 words
The method of claim 1 wherein R 1 is --SCH 3 , R 2 is hydrogen and R 3 is hydroxy.
Claim 9
Dependent Claim
10 words
The method of claim 1 wherein the compound is 1-(2-Deoxy-beta-D-ribofuranosyl)-5-(iodo)-2-pyrimidinone.
Claim 10
Dependent Claim
10 words
The method of claim 2 wherein the compound is 1-(2-Deoxy-beta-D-ribofuranosyl)-5-(ethynyl)-2-pyrimidinone.
References Cited (Backward Citations)
DD134429A3
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-08-28 | 1988-02-27 | 1988-08-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-08-28 | 1992-02-27 | 1992-08-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-08-28 | 1996-02-27 | 1996-08-28 | $7700.00 | Window Closed / Lapsed |