US4465662A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Oral compositions of tranexamic acid and carvone
Assignee: Lion Corp
•
Filing: 1981-04-02
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Granted: 1984-08-14
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Expires: 2001-04-02
Abstract
Abstract An oral composition containing tranexamic acid in which carvone is blended in an amount of 0.1 to 5% by weight and l-menthol may preferably be blended in an amount of 0.03 to 10% by weight. Carvone improves the bitterness inherent to the tranexamic acid-containing oral composition. The composition may preferably contain a mixed humectant of sorbitol and glycerin at a weight ratio of 1:9 to 6:4 and a binder, at least 60% by weight of the binder being an alkali metal salt of carboxymethyl cellulose.
Inventors
- 👤 Hiroshi Sato
- 👤 Haruo Watanabe
- 👤 Nobuo Suganuma
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 07:34
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/40; A61K8/44; A61Q; A61Q11/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
80 words
An oral composition for topical use having an effective anti-inflammatory and hemostyptic amount of tranexamic acid, consisting essentially of: 0.01 to 5% by weight of tranexamic acid; 0.1 to 5% by weight of carvone; 0.03 to 10% by weight of l-menthol wherein the weight ratio of carvone and l-menthol is in the range of from 3:7 to 7:3; 5 to 85% by weight of a mixed humectant of sorbitol and glycerine blended at a weight ratio of 1:9 to 6:4;
Claim 2
Dependent Claim
80 words
An oral composition for topical use having an effective anti-inflammatory and hemostyptic amount of tranexamic acid, consisting essentially of: 0.01 to 5% by weight of tranexamic acid; 0.1 to 5% by weight of carvone; 0.03 to 10% by weight of l-menthol wherein the weight ratio of carvone and l-menthol is in the range of from 3:7 to 7:3; 5 to 85% by weight of a mixed humectant of sorbitol and glycerine blended at a weight ratio of 1:9 to 6:4;
Claim 3
Dependent Claim
84 words
3 to 5% by weight of a binder containing at least 60% by weight of an alkali metal salt of carboxymethyl cellulose; and not less than 1% and not more than 5% by weight of propylene glycol wherein the oral composition exhibits reduced bitterness due to the tranexamic acid and exhibits good storage stability upon long-term aging said composition avoiding the discoloration upon aging, and undesired scorching taste, imparted by more than 5% by weight of propylene glycol to tranexamic acid containing oral compositions.
Claim 4
Dependent Claim
84 words
3 to 5% by weight of a binder containing at least 60% by weight of an alkali metal salt of carboxymethyl cellulose; and not less than 1% and not more than 5% by weight of propylene glycol wherein the oral composition exhibits reduced bitterness due to the tranexamic acid and exhibits good storage stability upon long-term aging said composition avoiding the discoloration upon aging, and undesired scorching taste, imparted by more than 5% by weight of propylene glycol to tranexamic acid containing oral compositions.
Claim 5
Dependent Claim
22 words
An oral composition according to claim 1, wherein the carvone and l-menthol are blended at a weight ratio of 3:7 to 7:3.
Claim 6
Dependent Claim
45 words
An oral composition according to claim 1, which further contains a mixed humectant of sorbitol and glycerine blended at a weight ratio of 1:9 to 6:4 and a binder, at least 60% by weight of the binder being an alkali metal salt of carboxymethyl cellulose.
Claim 7
Dependent Claim
68 words
An oral composition according to claim 1, wherein a mixed humectant of sorbitol and glycerine blended at a weight ratio of 1:9 to 6:4 is present in an amount of 5 to 85% by weight of the composition and wherein the composition contains 0.3 to 5% by weight of the composition of a binder containing at least 60% by weight of an alkali metal salt of carboxymethyl cellulose.
Claim 8
Dependent Claim
110 words
An oral composition for topical use comprising: 0.01 to 5% by weight of tranexamic acid; 0.1 to 5% by weight of carvone; 0.03 to 10% by weight of l-menthol; not less than 1% and not more than 5% by weight of propylene glycol; and a carrier, wherein the weight ratio of carvone and l-menthol is in the range of from 1:9 to 9:1 wherein the oral composition exhibits reduced bitterness due to the tranexamic acid and exhibits good storage stability upon long-term aging said composition avoiding the discoloration upon aging, and undesired scorching taste, imparted by more than 5% by weight of propylene glycol to tranexamic acid containing oral compositions.
Claim 9
Dependent Claim
110 words
An oral composition for topical use comprising: 0.01 to 5% by weight of tranexamic acid; 0.1 to 5% by weight of carvone; 0.03 to 10% by weight of l-menthol; not less than 1% and not more than 5% by weight of propylene glycol; and a carrier, wherein the weight ratio of carvone and l-menthol is in the range of from 1:9 to 9:1 wherein the oral composition exhibits reduced bitterness due to the tranexamic acid and exhibits good storage stability upon long-term aging said composition avoiding the discoloration upon aging, and undesired scorching taste, imparted by more than 5% by weight of propylene glycol to tranexamic acid containing oral compositions.
References Cited (Backward Citations)
US3720762A
Cited
JPS4939818A
Cited
JPS54129138A
Cited
JPS5519235A
Cited
BE887315A
Cited
US4272513A
Cited
US4272512A
Cited
US4309410A
Cited
JPS56110609A
Cited
GB2073019A
Cited
JPS56142205A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-08-14 | 1988-02-13 | 1988-08-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-08-14 | 1992-02-13 | 1992-08-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-08-14 | 1996-02-13 | 1996-08-14 | $7700.00 | Window Closed / Lapsed |