US4464399A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Octodiol, a solvent for direct dissolution of cholesterol gallstones
Assignee: University of California
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Filing: 1983-06-21
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Granted: 1984-08-07
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Expires: 2003-06-21
Abstract
Abstract The use of a compound having the general formula: <IMAGE> wherein n is 0 or a small integer, normally from 1 to 3; R is an alkyl or alkenyl group containing from 4 to 18 carbon atoms; and X is oxygen, sulfur or amide <IMAGE> with the further proviso that any one or more of the OH groups can be replaced by a polar zwitterionic group such as NH4+ SO3-; for the treatment of cholesterol gallstones by infusion of the solvent around the gallstones to dissolve them.
Inventors
- 👤 Alan F. Hofmann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 06:43
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/075; A61K31/08; A61K31/095; A61K31/10; A61K31/13; A61K31/14; A61K31/16
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
49 words
The method of treating gallstones in a human afflicted with gallstones which comprises administering to said human by infusion around the gallstones to dissolve them, an effective amount for treating gallstones, of the monooctyl ether of glycerol having the formula C 8 H 17 OCH 2 CHOHCH 2 OH.
Claim 2
Independent Claim
49 words
The method of treating gallstones in a human afflicted with gallstones which comprises administering to said human by infusion around the gallstones to dissolve them, an effective amount for treating gallstones, of the monooctyl ether of glycerol having the formula C 8 H 17 OCH 2 CHOHCH 2 OH.
Claim 3
Dependent Claim
29 words
The method of claim 1 wherein the drug is used in an effective amount on the order of 1 to 5 ml per hour per 150 mg of gallstone.
Claim 4
Dependent Claim
11 words
The method of claim 1 wherein the drug is administered neat.
Claim 5
Dependent Claim
17 words
The method of claim 1 wherein the drug is administered together with a small amount of water.
Claim 6
Dependent Claim
12 words
The method of claim 1 wherein the drug is infused by T-tubes.
Claim 7
Dependent Claim
11 words
The method of claim 1 wherein the drug is infused endoscopically.
References Cited (Backward Citations)
GB1029610A
Cited
US4205086A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-08-07 | 1988-02-06 | 1988-08-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-08-07 | 1992-02-06 | 1992-08-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-08-07 | 1996-02-06 | 1996-08-07 | $7700.00 | Window Closed / Lapsed |