US4464372A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Imidazo[1,2-b]pyridazines
Assignee: Merck Sharp & Dohme LLC
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Filing: 1982-08-16
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Granted: 1984-08-07
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Expires: 2002-08-16
Abstract
Abstract There are disclosed herein certain substituted imidazo[1,2-b]pyridazine compounds which are useful in the treatment of peptic ulcer diseases.
Inventors
- 👤 James A. Bristol
- 👤 Raymond G. Lovey
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 20:15
CPC Classifications
C; C07; C07D; C07D487/00; C07D487/02; C07D487/04
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
40 words
A compound represented by the formula: ##STR41## and pharmaceutically acceptable salts thereof, wherein R' 2 and R' 3 independently represent methyl, cyanomethyl or amino; X' represents hydrogen or methyl; and Z'--T' m --W' represents phenylmethoxy, phenylmethanamino, phenylethyl, 2-phenylethenyl or 3-phenyl-1-propenyl.
Claim 2
Dependent Claim
40 words
A compound represented by the formula: ##STR41## and pharmaceutically acceptable salts thereof, wherein R' 2 and R' 3 independently represent methyl, cyanomethyl or amino; X' represents hydrogen or methyl; and Z'--T' m --W' represents phenylmethoxy, phenylmethanamino, phenylethyl, 2-phenylethenyl or 3-phenyl-1-propenyl.
Claim 3
Dependent Claim
22 words
The compound of claim 1 wherein R' 2 and R' 3 are each methyl; and Z'--T' m --W' is phenylethenyl, i.e. 2,3-dimethyl-8-phenylenthenylimidazo[1,2-b]pyridazine.
Claim 4
Dependent Claim
22 words
The compound of claim 1 wherein R' 2 is methyl, R' 3 is cyanomethyl and Z'--T' m --W' is phenylmethoxy, i.e. 2-methyl-8-phenylmethoxyimidazo[1,2-b]pyridazine-3-acetonitrile.
Claim 5
Dependent Claim
22 words
The compound of claim 1 wherein R' 2 is methyl, R' 3 is amino and Z'--T' m --W' is phenylmethoxy, i.e. 8-phenylmethoxy-2-methyl-3-aminoimidazo[1,2-b]pyridazine.
Claim 6
Dependent Claim
34 words
A method for the treatment of the symptoms of peptic ulcer disease in mammals, which comprises administering to a mammal having peptic ulcer disease a therapeutically effective amount of a compound of claim 1.
Claim 7
Dependent Claim
29 words
A method for the treatment of gastric ulcers in mammals which comprises administering to a mammal having gastric ulcers a therapeutically effective amount of a compound of claim 1.
Claim 8
Dependent Claim
29 words
A method for the treatment of duodenal ulcers in mammals which comprises administering to a mammal having duodenal ulcers a therapeutically effective amount of a compound of claim 1.
Claim 9
Dependent Claim
49 words
A method for inhibiting gastrointestinal irritation and damage in mammals due to administration of drugs which induce gastrointestinal irritation and damage which comprises administering a therapeutically effective amount of a compound of claim 1 during the term said gastro-intestinal irritating and damaging drug is administered for its therapeutic effect.
Claim 10
Dependent Claim
31 words
A method for the treatment of gastrointestinal damage due to stress which comprises administering to a mammal suffering from such damage a therapeutically effective amount of a compound of claim 1.
Claim 11
Dependent Claim
28 words
A method of claim 10 which comprises administering to a mammal having peptic ulcer disease, a therapeutically effective amount of a compound of claims 2, 3 or 4.
Claim 12
Dependent Claim
37 words
A pharmaceutical compound for use in the treatment of ulcers which comprises a compound of claim 1 in a therapeutically effective amount sufficient to alleviate the symptoms of peptic ulcer disease together with a pharmaceutically acceptable carrier.
Claim 13
Dependent Claim
24 words
A pharmaceutical compound of claim 11 which comprises a therapeutically effective amount of a compound of claim 2 together with a pharmaceutically acceptable carrier.
Claim 14
Dependent Claim
24 words
A pharmaceutical compound of claim 11 which comprises a therapeutically effective amount of a compound of claim 3 together with a pharmaceutically acceptable carrier.
Claim 15
Dependent Claim
24 words
A pharmaceutical formulation of claim 11 which comprises a therapeutically effective amount of a compound of claim 4 together with a pharmaceutically acceptable carrier.
Claim 16
Dependent Claim
13 words
A pharmaceutical composition of claims 11, 12 or 13 suitable for oral administration.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-08-07 | 1988-02-06 | 1988-08-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-08-07 | 1992-02-06 | 1992-08-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-08-07 | 1996-02-06 | 1996-08-07 | $7700.00 | Window Closed / Lapsed |