US4464354A
Expired / Lapsed
US
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(3,4-c)-Pyrido psoralens, process of preparation, application in cosmetology and therapeutics, and cosmetological and pharmaceutical composition with them
Assignee: Institut National de la Santé et de la Recherche Médicale
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Filing: 1983-02-24
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Granted: 1984-08-07
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Expires: 2003-02-24
Abstract
Abstract Monofunctional psoralen derivatives having the general formula ##STR1## wherein R represents a hydrogen atom, a lower alkyl group having from 1 to 4 atoms, preferably a methyl radical, or a lower alkoxy radical having from 1 to 4 carbon atoms, preferably a methoxy radical are described. The derivatives are photobiologically active and are useful in photochemical therapy and in cosmetics.
Inventors
- 👤 Emile Bisagni
- 👤 Louis Dubertret
- 👤 Jacqueline Moron
- 👤 Dietrich Averbeck
- 👤 Dora Papadopoulo
- 👤 Jocelyne Blais
- 👤 Paul Vigny
- 👤 Maria N. Schwencke
- 👤 Ethel Moustacchi
- 👤 Silvano Nocentini
- 👤 Francois Zajdela
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 10:42
CPC Classifications
C; C07; C07D; C07D491/00; C07D491/12; C07D491/14; A; A61; A61P; A61P17/00; A61P29/00; A61P37/00; A61P37/08
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
37 words
Pyrido (3,4-c)-psoralens or pyrido (3,4-c) furo (3,2-g) coumarins having the following formula: ##STR6## wherein R is selected from the group consisting of a hydrogen atom, and a lower alkyl group having from 1 to 4 carbon atoms.
Claim 2
Dependent Claim
37 words
Pyrido (3,4-c)-psoralens or pyrido (3,4-c) furo (3,2-g) coumarins having the following formula: ##STR6## wherein R is selected from the group consisting of a hydrogen atom, and a lower alkyl group having from 1 to 4 carbon atoms.
Claim 3
Dependent Claim
20 words
Pyrido (3,4-c)-psoralens or pyrido (3,4-c) furo (3,2-g) coumarins of claim 1, wherein the lower alkyl group is a methyl radical.
Claim 4
Dependent Claim
29 words
Pyrido (3,4-c)-psoralens or pyrido (3,4-c) furo (3,2-g) coumarins of claim 1, wherein the radical R is selected from the group consisting of a hydrogen atom and the methyl radical.
Claim 5
Dependent Claim
70 words
A pharmaceutical composition to treat inflammatory skin disorders for administering to a subject having said inflammatory skin disorder containing a pharmaceutically effective amount of an active ingredient comprising pyrido (3,4-c)-psoralen or pyrido (3,4-c) furo (3,2-g) coumarin having the following formula: ##STR7## wherein R is selected from the group consisting of a hydrogen atom, and a lower alkyl group having from 1 to 4 carbon atoms and a pharmaceutically acceptable vehicle.
Claim 6
Dependent Claim
70 words
A pharmaceutical composition to treat inflammatory skin disorders for administering to a subject having said inflammatory skin disorder containing a pharmaceutically effective amount of an active ingredient comprising pyrido (3,4-c)-psoralen or pyrido (3,4-c) furo (3,2-g) coumarin having the following formula: ##STR7## wherein R is selected from the group consisting of a hydrogen atom, and a lower alkyl group having from 1 to 4 carbon atoms and a pharmaceutically acceptable vehicle.
Claim 7
Dependent Claim
22 words
The pharmaceutical composition of claim 4, wherein the pharmaceutically acceptable vehicle is suitable for local administration and comprises an ointment or solution.
Claim 8
Dependent Claim
25 words
The pharmaceutical composition of claim 4, wherein said pharmaceutically effective amount of the active ingredient is from about 0.1-2% by weight of the pharmaceutical composition.
Claim 9
Dependent Claim
20 words
The pharmaceutical composition of claim 6, wherein the pharmaceutically effective amount is about 0.5% by weight of the pharmaceutical composition.
Claim 10
Dependent Claim
33 words
The pharmaceutical composition of claim 4 wherein said composition is administered with other agents selected from the group consisting of ointments, solutions, coloring agents, sun filters, preservatives, photosensitizers, photoprotective agents and ultraviolet radiation.
Claim 11
Dependent Claim
13 words
The composition of claim 4 wherein said composition has photochemical or photobiological activity.
Claim 12
Dependent Claim
18 words
The composition of claim 9 wherein said photochemical or photobiological activity is induced by exposure to ultraviolet light.
Claim 13
Dependent Claim
10 words
The composition of claim 4 wherein said composition is pigmentogenic.
Claim 14
Dependent Claim
15 words
The composition of claim 4 wherein said pigmentogenicity is induced by exposure to ultraviolet light.
Claim 15
Dependent Claim
15 words
The composition of claim 4 wherein said inflammatory skin disorder is pigmentation disorder or photodermatoses.
Claim 16
Dependent Claim
11 words
The composition of claim 13 wherein said skin disorder is psoriasis.
Claim 17
Dependent Claim
50 words
A cosmetic composition with at least one pyrido (3,4-c)-psoralen or pyrido (3,4-c) furo (3,2-g) coumarin having the following formula: ##STR8## wherein R is selected from the group consisting of a hydrogen atom, and a lower alkyl having from 1 to 4 carbon atoms, and a vehicle suitable for external use.
Claim 18
Dependent Claim
50 words
A cosmetic composition with at least one pyrido (3,4-c)-psoralen or pyrido (3,4-c) furo (3,2-g) coumarin having the following formula: ##STR8## wherein R is selected from the group consisting of a hydrogen atom, and a lower alkyl having from 1 to 4 carbon atoms, and a vehicle suitable for external use.
Claim 19
Dependent Claim
30 words
The cosmetic composition of claim 15, wherein the active ingredient is present in an amount from about 0.01 to about 0.5% by weight with respect to the total cosmetic composition.
References Cited (Backward Citations)
US4260630A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-08-07 | 1988-02-06 | 1988-08-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-08-07 | 1992-02-06 | 1992-08-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-08-07 | 1996-02-06 | 1996-08-07 | $7700.00 | Window Closed / Lapsed |