US4463003A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Cephem compounds
Assignee: Astellas Pharma Inc
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Filing: 1982-12-22
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Granted: 1984-07-31
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Expires: 2002-12-22
Abstract
Abstract The invention relates to novel cephem compounds, of antimicrobial activity, of the formula: ##STR1## wherein R 1 is carboxy (C 1 -C 6 ) alkyl or esterified carboxy (C 1 -C 6 ) alkyl, R 2 is carboxy or esterified carboxy, and R 3 is (C 1 -C 6 ) alkanoyloxy (C 1 -C 6 ) alkyl, tetrazolopyridazinylthio (C 1 -C 6 ) alkyl, tetrazolothio (C 1 -C 6 ) alkyl, or (C 1 -C 6 ) alkyl tetrazolothio (C 1 -C 6 ) alkyl, and pharmaceutically acceptable salts thereof.
Inventors
- 👤 Takao Takaya
- 👤 Hisashi Takasugi
- 👤 Hideaki Yamanaka
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-10 00:50
CPC Classifications
C; C07; C07D; C07D501/00; C07D501/14; C07D501/16; C07D501/20; A; A61; A61P; A61P31/00; A61P31/04
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
82 words
A compound of the formula: ##STR6## wherein R 1 is carboxy (C 1 -C 6 ) alkyl or esterified carboxy (C 1 -C 6 ) alkyl, R 2 is carboxy or esterified carboxy, and R 3 is (C 1 -C 6 ) alkanoyloxy (C 1 -C 6 ) alkyl, tetrazolopyridazinylthio (C 1 -C 6 ) alkyl, tetrazolothio (C 1 -C 6 ) alkyl, or (C 1 -C 6 ) alkyl tetrazolothio (C 1 -C 6 ) alkyl, and pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
82 words
A compound of the formula: ##STR6## wherein R 1 is carboxy (C 1 -C 6 ) alkyl or esterified carboxy (C 1 -C 6 ) alkyl, R 2 is carboxy or esterified carboxy, and R 3 is (C 1 -C 6 ) alkanoyloxy (C 1 -C 6 ) alkyl, tetrazolopyridazinylthio (C 1 -C 6 ) alkyl, tetrazolothio (C 1 -C 6 ) alkyl, or (C 1 -C 6 ) alkyl tetrazolothio (C 1 -C 6 ) alkyl, and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
11 words
A compound of claim 1, which is 7-[2-carboxymethoxyimino-2-(1,2,4-thiadiazol-3-yl)acetamido]-3-(tetrazolo[1,5-b]pyridazin-6-yl)thiomethyl-3-cephem-4-carboxylic acid (syn isomer).
Claim 4
Dependent Claim
11 words
A compound of claim 1, which is 7-[2-carboxymethoxyimino-2-(1,2,4-thiadiazol-3-yl)acetamido]cephalosporanic acid (syn isomer).
Claim 5
Dependent Claim
11 words
A compound of claim 1, which is 7-[2-carboxymethoxyimino-2-(1,2,4-thiadiazol-3-yl)acetamido]-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid (syn isomer).
Claim 6
Dependent Claim
23 words
An antibacterial composition comprising an effective of a compound of claim 1 in association with a pharmaceutically acceptable substantially non-toxic carrier or excipient.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-07-31 | 1988-01-30 | 1988-07-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-07-31 | 1992-01-30 | 1992-07-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-07-31 | 1996-01-30 | 1996-07-31 | $7700.00 | Window Closed / Lapsed |