US4461771A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Treatment of migraine with dioxopiperidine derivatives
Assignee: BTG International Ltd
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Filing: 1983-03-01
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Granted: 1984-07-24
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Expires: 2003-03-01
Abstract
Abstract Migraine is treated with a 3-phenyl-3-aminoalkyl-4,4-dimethyl-2,6-dioxopiperidine derivative of the following general Formula I: <IMAGE> wherein: R1 represents methoxy, ethoxy and hydroxy; R2 represents methoxy, ethoxy, hydroxy or hydrogen, each R3 independently represents methyl or ethyl; and n represents 2 or 3, or a pharmaceutically acceptable acid addition salt thereof.
Inventors
- 👤 Maurice W. Gittos
- 👤 David A. Amey
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 22:54
CPC Classifications
C; C07; C07D; C07D211/00; C07D211/04; C07D211/80; C07D211/84; C07D211/86; C07D211/88
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
67 words
A method of prophylaxis of migraine which comprises administering to a patient suffering from migraine, an effective migraine-prophylactic amount of a compound of the following general Formula I: ##STR5## wherein: R 1 represents methoxy, ethoxy and hydroxy; R 2 represents methoxy, ethoxy, hydroxy or hydrogen, each R 3 independently represents methyl or ethyl; and n represents 2 or 3, or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Independent Claim
67 words
A method of prophylaxis of migraine which comprises administering to a patient suffering from migraine, an effective migraine-prophylactic amount of a compound of the following general Formula I: ##STR5## wherein: R 1 represents methoxy, ethoxy and hydroxy; R 2 represents methoxy, ethoxy, hydroxy or hydrogen, each R 3 independently represents methyl or ethyl; and n represents 2 or 3, or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
22 words
A method as claimed in claim 1 wherein the said compound is administered in an amount of 0.01 mg/kg to 10 mg/kg.
Claim 4
Dependent Claim
22 words
A method as claimed in claim 2 wherein the said compound is administered in an amount of 0.1 mg/kg to 3 mg/kg.
Claim 5
Dependent Claim
22 words
A method as claimed in claim 1 wherein R 1 represents methoxy or hydroxy and R 2 represents methoxy, hydroxy or hydrogen.
Claim 6
Dependent Claim
12 words
A method as claimed in claim 1 wherein R 2 represents hydrogen.
Claim 7
Dependent Claim
13 words
A method as claimed in claim 1 wherein each R 3 represents methyl.
Claim 8
Dependent Claim
11 words
A method as claimed in claim 1 wherein n represents 3.
Claim 9
Dependent Claim
27 words
A method as claimed in claim 1 wherein R 1 is methoxy or hydroxy, R 2 is hydrogen, each R 3 is methyl and n is 3.
Claim 10
Dependent Claim
13 words
A method as claimed in claim 1 wherein the compound is 3-(3'-methoxyphenyl)-3-(3"-N,N-dimethylamino) 2,6-dioxopiperidine.
References Cited (Backward Citations)
US3963729A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-07-24 | 1988-01-23 | 1988-07-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-07-24 | 1992-01-23 | 1992-07-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-07-24 | 1996-01-23 | 1996-07-24 | $7700.00 | Window Closed / Lapsed |