US4459306A
Expired / Lapsed
US
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Tricyclic ethers, their process of preparation and their use as medicines
Assignee: Science Union et Cie
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Filing: 1981-04-06
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Granted: 1984-07-10
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Expires: 2001-04-06
Abstract
Abstract This invention relates to novel tricyclic ethers, pharmaceutically acceptable addition salts and optical isomers therefrom. The compounds described herein are useful as psychotropic agents in the treatment of depression and anxiety. Also included herein are methods of preparing said compounds, pharmaceutical compositions including them and methods of treating human or animal beings by administering these pharmaceutical compositions.
Inventors
- 👤 Charles Malen
- 👤 Jean-Claude Poignant
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 12:21
CPC Classifications
C; C07; C07D; C07D321/00; C07D321/02; C07D321/10; A; A61; A61P; A61P25/00; A61P25/02; A61P25/08; A61P25/18; A61P25/20; A61P25/24; A61P25/26; C07D327/00; C07D327/02
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
115 words
A compound selected from the group consisting of a substituted 11 H-dibenzooxepine of formula I: ##STR23## wherein R and R', the same or different, are hydrogen, halogen, lower-alkyl, lower-alkoxy, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, lower-alkylenedioxy, or lower-alkylthio, A represents oxygen or sulphur, R 1 and R 2 , the same or different, represent hydrogen, lower-alkyl, or lower-hydroxyalkyl, n represents an integer of 2 to 4, inclusive, m and m', the same or different, are the integers 1 or 2, lower-alkyl, lower-alkoxy, lower-hydroxyalkyl, lower-alkylenedioxy, and lower-alkylthio, as used in the foregoing, having in each case one to five carbon atoms, inclusive, an acid addition salt thereof with a therapeutically-compatible mineral or organic acid, and an optical isomer thereof.
Claim 2
Dependent Claim
115 words
A compound selected from the group consisting of a substituted 11 H-dibenzooxepine of formula I: ##STR23## wherein R and R', the same or different, are hydrogen, halogen, lower-alkyl, lower-alkoxy, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, lower-alkylenedioxy, or lower-alkylthio, A represents oxygen or sulphur, R 1 and R 2 , the same or different, represent hydrogen, lower-alkyl, or lower-hydroxyalkyl, n represents an integer of 2 to 4, inclusive, m and m', the same or different, are the integers 1 or 2, lower-alkyl, lower-alkoxy, lower-hydroxyalkyl, lower-alkylenedioxy, and lower-alkylthio, as used in the foregoing, having in each case one to five carbon atoms, inclusive, an acid addition salt thereof with a therapeutically-compatible mineral or organic acid, and an optical isomer thereof.
Claim 3
Dependent Claim
17 words
An acid addition salt of a compound of claim 1 with a therapeutically-compatible mineral or organic acid.
Claim 4
Dependent Claim
14 words
An optical isomer of a compound as claimed in claim 1 or claim 2.
Claim 5
Dependent Claim
28 words
Compound of claim 1 which is selected from the group consisting of dl N-diethyl 2-[11 H-dibenzo (b,e)-1,4-dioxepin-11-yl] ethylamine, an acid addition salt thereof, and an optical isomer thereof.
Claim 6
Dependent Claim
28 words
Compound of claim 1 which is selected from the group consisting of dl N-dimethyl 2-[11 H-dibenzo (b,e)-1,4-dioxepin-11-yl] ethylamine, an acid addition salt thereof, and an optical isomer thereof.
Claim 7
Dependent Claim
29 words
Compound of claim 1 which is selected from the group consisting of dl N-diethyl 2-[2-chloro 11 H-dibenzo (b,e)-1,4-dioxepin-11-yl] ethlyamine, an acid addition salt thereof, and an optical isomer thereof.
Claim 8
Dependent Claim
27 words
Compound of claim 1 which is selected from the group consisting of dl 3-[11 H-dibenzo (b,e)-1,4-dioxepin-11-yl] propylamine, an acid addition salt thereof, and an optical isomer thereof.
Claim 9
Dependent Claim
28 words
Compound of claim 1 which is selected from the group consisting of dl N-diethyl 3-[11 H-dibenzo (b,e)-1,4-dioxepin-11-yl] propylamine, an acid addition salt thereof, and an optical isomer thereof.
Claim 10
Dependent Claim
29 words
Compound of claim 1 which is selected from the group consisting of dl N-diethyl 2-[3-chloro 11 H-dibenzo (b,e)-1,4-dioxepin-11-yl] ethylamine, an acid addition salt thereof, and an optical isomer thereof.
Claim 11
Dependent Claim
29 words
Compound of claim 1 which is selected from the group consisting of dl N-diethyl 2-[8-chloro 11 H-dibenzo (b,e)-1,4-dioxepin-11-yl] ethylamine, an acid addition salt thereof, and an optical isomer thereof.
Claim 12
Dependent Claim
29 words
Compound of claim 1 which is selected from the group consisting of dl N-sec butyl 2-[11 H-dibenzo (b,e)-1,4-dioxepin-11-yl] ethylamine, an acid addition salt thereof, and an optical isomer thereof.
Claim 13
Dependent Claim
28 words
Compound of claim 1 which is selected from the group consisting of dl N-terbutyl 2-[11 H-dibenzo (b,e)-1,4-dioxepin-11-yl] ethylamine, an acid addition salt thereof, and an optical isomer thereof.
Claim 14
Dependent Claim
28 words
Compound of claim 1 which is selected from the group consisting of dl N-methyl 2-[11 H-dibenzo (b,e)-1,4-dioxepin-11-yl] ethylamine, an acid addition salt thereof, and an optical isomer thereof.
Claim 15
Dependent Claim
28 words
Compound of claim 1 which is selected from the group consisting of dl N-isopropyl 2-[11 H-dibenzo (b,e)-1,4-dioxepin-11-yl] ethylamine, an acid addition salt thereof, and an optical isomer thereof.
Claim 16
Dependent Claim
29 words
Compound of claim 1 which is selected from the group consisting of dl N-diethyl 2-[7,8-dichloro 11 H-dibenzo (b,e)-1,4-dioxepin-11-yl] ethylamine, an acid addition salt thereof, and an optical isomer thereof.
Claim 17
Dependent Claim
29 words
Compound of claim 1 which is selected from the group consisting of dl N-dimethyl 2-[2-trifluoromethyl 11 H-dibenzo (b,e)-1,4-dioxepin-11-yl] ethylamine, an acid addition salt thereof, and an optical isomer thereof.
Claim 18
Dependent Claim
28 words
Compound of claim 1 which is selected from the group consisting of dl N-diethyl 2-[11 H-dibenzo (b,e)-1,4-thioxepin-11-yl] ethylamine, an acid addition salt thereof, and an optical isomer thereof.
Claim 19
Dependent Claim
30 words
A pharmaceutical composition comprising as active ingredient at least one compound as claimed in claim 1 or an acid addition salt thereof in conjunction with an inert, non-toxic pharmaceutically-acceptable carrier.
Claim 20
Dependent Claim
22 words
A pharmaceutical composition as claimed in claim 18 wherein the active ingredient is present at a dosage of 0.5 to 10 mg.
Claim 21
Dependent Claim
24 words
A pharmaceutical composition as claimed in claim 18 which is in a pharmaceutical form adapted to administration by oral, rectal, parenteral, or sublingual route.
Claim 22
Dependent Claim
44 words
A method of treating central nervous system disorders in mammals, which comprises administering to a patient suffering from such condition a therapeutically effective amount of a compound of claim 1 or a pharmaceutical composition as claimed in claim 18, claim 19, or claim 20.
Claim 23
Dependent Claim
29 words
A compound of claim 1 which is selected from the group consisting of dl N-dimethyl 2-[11 H-dibenzo (b,e)-1,4-thioxepin-11-yl] ethylamine, an acid addition salt thereof, or an optical isomer thereof.
References Cited (Backward Citations)
FR1312891A
Cited
FR1312889A
Cited
US3758528A
Cited
US3821249A
Cited
FR2315272A1
Cited
US4335122A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-07-10 | 1988-01-09 | 1988-07-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-07-10 | 1992-01-09 | 1992-07-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-07-10 | 1996-01-09 | 1996-07-10 | $7700.00 | Window Closed / Lapsed |