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US4457846A
Expired / Lapsed
US
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Liquid chromatography methods and devices
Assignee: LDC Analytical Inc
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Filing: 1982-07-08
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Granted: 1984-07-03
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Expires: 2002-07-08
Abstract
Abstract In the analysis of substances by liquid chromatography, samples to be analyzed are introduced into the chromatography column by being loaded into a fluid permeable section in a cartridge, placing the sample loaded section over the inlet end of the column and flowing solvent through such section into the column. The cartridge may be a plate with an opening through it with the ends of the opening covered by permeable membranes or the opening may be packed with porous material. The cartridge may have a plurality of such openings and these may be in the form of a line on a rectangular plate or a circle on a circular plate. The new methods and devices of the invention are particularly useful in micro-scale liquid chromatographic procedures.
Inventors
- 👤 Miner N. Munk
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 23:50
CPC Classifications
G; G01; G01N; G01N30/00; G01N30/02; G01N30/04; G01N30/16; G01N30/06; G01N30/12; G01N2030/121
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
93 words
In the analysis of substances by liquid chromatography, the improved method of introducing a sample of substance to be analyzed into a chromatographic column which comprises: providing a cartridge comprising an impervious plate having a fluid permeable section of substantially the same cross-sectional area as said chromatographic column used in the analysis, loading said sample of said substance into said permeable section of said cartridge, placing said cartridge at the inlet end of said column with said permeable section covering said inlet end and flowing solvent into said column through said permeable section.
Claim 2
Dependent Claim
93 words
In the analysis of substances by liquid chromatography, the improved method of introducing a sample of substance to be analyzed into a chromatographic column which comprises: providing a cartridge comprising an impervious plate having a fluid permeable section of substantially the same cross-sectional area as said chromatographic column used in the analysis, loading said sample of said substance into said permeable section of said cartridge, placing said cartridge at the inlet end of said column with said permeable section covering said inlet end and flowing solvent into said column through said permeable section.
Claim 3
Dependent Claim
25 words
The method of claim 1 wherein said permeable section comprises an opening through said plate and a permeable membrane covers each end of said opening.
Claim 4
Dependent Claim
19 words
The method of claim 2 wherein the space in said opening between said membranes contains chemically inert porous material.
Claim 5
Dependent Claim
31 words
The method of claim 1 wherein said cartridge comprises a plate, said permeable section comprises an opening through said plate and said opening is packed with a chemically inert porous plug.
Claim 6
Dependent Claim
18 words
The method of claim 4 wherein said plate comprises a plurality of said openings packed with porous plugs.
Claim 7
Dependent Claim
21 words
The method of claim 5 wherein said plate is circular in shape and said openings form a circle on said plate.
Claim 8
Dependent Claim
27 words
The method of claim 5 wherein said plate is in the shape of an elongated rectangle and said openings form a longitudinal line centrally along said plate.
Claim 9
Dependent Claim
51 words
The method of claim 1 wherein said cartridge contains a pluraliy of said fluid permeable sections, each section is loaded with a separate sample for testing and said sections are placed seriatum over the inlet end of said column after which solvent is flowed through each said section into said column.
Claim 10
Dependent Claim
14 words
The method of claim 1 wherein said analysis is a micro-scale liquid chromatography procedure.
Claim 11
Dependent Claim
19 words
The method of claim 1 wherein said permeable section contains porous material that is interactive with said sample substance.
Claim 12
Dependent Claim
18 words
The method of claim 10 wherein said interactive porous material enhances the sample concentration by adsorption or absorption.
Claim 13
Dependent Claim
17 words
The method of claim 10 wherein said interactive porous material produces chemical pretreatment of said sample substance.
Claim 14
Dependent Claim
17 words
The method of claim 12 wherein said interactive porous material produces chemical tagging of said sample substance.
Claim 15
Dependent Claim
83 words
A cartridge for use in introducing a substance sample into a chromatography column which comprises; an impermeable plate formed of chemically inert material, a fluid permable section in said plate having a cross-sectional area substantially the same as the cross-sectional area of said column, and said fluid permeable section comprising means capable of retaining a liquid sample introduced into said section and of releasing the liquid sample into a stream of solvent when said solvent is passed through said section into said column.
Claim 16
Dependent Claim
83 words
A cartridge for use in introducing a substance sample into a chromatography column which comprises; an impermeable plate formed of chemically inert material, a fluid permable section in said plate having a cross-sectional area substantially the same as the cross-sectional area of said column, and said fluid permeable section comprising means capable of retaining a liquid sample introduced into said section and of releasing the liquid sample into a stream of solvent when said solvent is passed through said section into said column.
Claim 17
Dependent Claim
25 words
The cartridge of claim 14 wherein said permeable section comprises an opening through said plate and a permeable membrane covers each end of said opening.
Claim 18
Dependent Claim
19 words
The cartridge of claim 15 wherein the space in said opening between said membranes contains chemically inert porous material.
Claim 19
Dependent Claim
26 words
The cartridge of claim 14 wherein said permeable section comprises an opening through said plate and said opening is packed with a chemically inert porous plug.
Claim 20
Dependent Claim
18 words
The cartridge of claim 17 wherein said plate comprises a plurality of said openings packed with porous material.
Claim 21
Dependent Claim
21 words
The cartridge of claim 18 wherein said plate is circular in shape and said openings form a circle on said plate.
Claim 22
Dependent Claim
27 words
The cartridge of claim 18 wherein said plate is in the shape of an elongated rectangle and said openings form at least one line on said plate.
Claim 23
Dependent Claim
11 words
Liquid chromatographic apparatus comprising a cartridge as defined in claim 14.
Claim 24
Dependent Claim
113 words
Liquid chromatographic apparatus comprising: a micro-scale chromatographic column having a substantially uniform lumen throughout it length, a cartridge for introducing a substance sample into said column, said cartridge comprising: an impermeable plate formed of chemically inert material, a fluid permeable section in said plate having a cross-sectional area substantially the same size as said lumen of said column, said cartridge being positioned at the inlet end of said column with said section covering said lumen and means positioned in said section capable of retaining a liquid sample introduced into said section and of releasing said sample into a stream of solvent when said solvent is passed through said section into said said column.
Claim 25
Dependent Claim
113 words
Liquid chromatographic apparatus comprising: a micro-scale chromatographic column having a substantially uniform lumen throughout it length, a cartridge for introducing a substance sample into said column, said cartridge comprising: an impermeable plate formed of chemically inert material, a fluid permeable section in said plate having a cross-sectional area substantially the same size as said lumen of said column, said cartridge being positioned at the inlet end of said column with said section covering said lumen and means positioned in said section capable of retaining a liquid sample introduced into said section and of releasing said sample into a stream of solvent when said solvent is passed through said section into said said column.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-07-03 | 1988-01-02 | 1988-07-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-07-03 | 1992-01-02 | 1992-07-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-07-03 | 1996-01-02 | 1996-07-03 | $7700.00 | Window Closed / Lapsed |