US4454152A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Methoxsalen dosage forms
Assignee: ELDER PHARMACEUTICALS Inc AN IN CORP
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Filing: 1981-12-21
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Granted: 1984-06-12
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Expires: 2001-12-21
Abstract
Abstract This invention relates to oral dosage forms wherein the active ingredient, methoxsalen, is dispersed in a water-soluble composition containing a polyethylene glycol or mixtures of polyethylene glycols. Dissolution of methoxsalen in gastrointestinal fluids as well as drug absorption are more rapid and higher blood level patterns are achieved with these dosage forms as compared to conventional encapsulated dosage forms.
Inventors
- 👤 Richard H. Barry
- 👤 Jack H. Lazarus
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 20:44
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/49; A61K8/4973; A61K8/498; A61K31/00; A61K31/33; A61K31/335; A61K31/365; A61K31/366; A61K31/37; A61K9/00; A61K9/14; A61Q; A61Q17/00; A61Q17/04
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
104 words
A method of treating a subject afflicted with psoriasis or vitiligo which method comprises (a) administering to the subject an oral dosage composition comprising a solution of an amount of methoxsalen effective for the treatment of psoriasis or vitiligo in about 10 to about 97.5 percent by weight based on the total weight of the composition of a polyethylene glycol or a mixture of polyethylene glycols which polyethylene glycol or mixture is fluid at room temperature contained within a capsule. (b) waiting a sufficient time to obtain a peak blood level of methoxsalen in the subject, and (c) irradiating the subject with ultraviolet light.
Claim 2
Independent Claim
104 words
A method of treating a subject afflicted with psoriasis or vitiligo which method comprises (a) administering to the subject an oral dosage composition comprising a solution of an amount of methoxsalen effective for the treatment of psoriasis or vitiligo in about 10 to about 97.5 percent by weight based on the total weight of the composition of a polyethylene glycol or a mixture of polyethylene glycols which polyethylene glycol or mixture is fluid at room temperature contained within a capsule. (b) waiting a sufficient time to obtain a peak blood level of methoxsalen in the subject, and (c) irradiating the subject with ultraviolet light.
Claim 3
Dependent Claim
66 words
An oral dosage composition in a unit dosage form comprising a solution of an amount of methoxsalen effective for the treatment of psoriasis or vitiligo in about 10 to about 97.5 percent by weight based on the total weight of the composition of a polyethylene glycol or a mixture of polyethylene glycols which polyethylene glycol or mixture is fluid at room temperature contained within a capsule.
Claim 4
Dependent Claim
66 words
An oral dosage composition in a unit dosage form comprising a solution of an amount of methoxsalen effective for the treatment of psoriasis or vitiligo in about 10 to about 97.5 percent by weight based on the total weight of the composition of a polyethylene glycol or a mixture of polyethylene glycols which polyethylene glycol or mixture is fluid at room temperature contained within a capsule.
Claim 5
Dependent Claim
64 words
An oral dosage composition in unit dosage form comprising a solution, which in percent by weight based on the total weight of the composition, is from about 0.025% to about 10.5% of methoxsalen and from about 10% to about 97.5% of a polyethylene glycol or a mixture of polyethylene glycols which polyethylene glycol or mixture is fluid at room temperature, contained within a capsule.
Claim 6
Dependent Claim
64 words
An oral dosage composition in unit dosage form comprising a solution, which in percent by weight based on the total weight of the composition, is from about 0.025% to about 10.5% of methoxsalen and from about 10% to about 97.5% of a polyethylene glycol or a mixture of polyethylene glycols which polyethylene glycol or mixture is fluid at room temperature, contained within a capsule.
References Cited (Backward Citations)
US3972999A
Cited
US4130568A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-06-12 | 1987-12-12 | 1988-06-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-06-12 | 1991-12-12 | 1992-06-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-06-12 | 1995-12-12 | 1996-06-12 | $7700.00 | Window Closed / Lapsed |