US4451476A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Isoxazoles as antiviral agents
Assignee: STWB Inc
•
Filing: 1983-10-17
•
Granted: 1984-05-29
•
Expires: 2003-10-17
Abstract
Abstract Compounds of the formulas: ##STR1## wherein R is alkyl, X is O or CH 2 , n is an integer from 4 to 8, and Ar is phenyl or substituted phenyl are useful as antiviral agents especially against picornaviruses.
Inventors
- 👤 Guy D. Diana
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 04:07
CPC Classifications
C; C07; C07D; C07D261/00; C07C; C07C255/00; C07D261/02; C07D261/06; C07D261/08
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
62 words
A compound having the formula ##STR5## wherein: R is alkyl of 1 to 3 carbon atoms; X is O or CH 2 ; n is an integer from 4 to 8; and Ar is phenyl or phenyl substituted by one or two substituents selected from the group consisting of halogen, lower-alkyl, lower-alkoxy, nitro, cyano, carboxy, lower-alkoxycarbonyl, lower-alkanoyl, 1-oximino-lower-alkyl, hydrazinocarbonyl, carbamyl and N,N-di-lower-alkylcarbamyl.
Claim 2
Dependent Claim
62 words
A compound having the formula ##STR5## wherein: R is alkyl of 1 to 3 carbon atoms; X is O or CH 2 ; n is an integer from 4 to 8; and Ar is phenyl or phenyl substituted by one or two substituents selected from the group consisting of halogen, lower-alkyl, lower-alkoxy, nitro, cyano, carboxy, lower-alkoxycarbonyl, lower-alkanoyl, 1-oximino-lower-alkyl, hydrazinocarbonyl, carbamyl and N,N-di-lower-alkylcarbamyl.
Claim 3
Dependent Claim
10 words
A compound according to claim 1 having the formula ##STR6##
Claim 4
Dependent Claim
18 words
A compound according to claim 2 where X is O, R is CH 3 and Ar is 2-chloro-4-methoxyphenyl.
Claim 5
Dependent Claim
5 words
5-[7-(2-Chloro-4-methoxyphenoxy)heptyl]-3-methylisoxazole, according to claim 3.
Claim 6
Dependent Claim
5 words
5-[6-(2-Chloro-4-methoxyphenoxy)hexyl]-3-methylisoxazole, according to claim 3.
Claim 7
Dependent Claim
5 words
5-[5-(2-Chloro-4-methoxyphenoxy)pentyl]-3-methylisoxazole, according to claim 3.
Claim 8
Dependent Claim
18 words
A compound according to claim 2 wherein X is O, R is CH 3 and Ar is lower-alkoxycarbonylphenyl.
Claim 9
Dependent Claim
5 words
5-[7-(4-Ethoxycarbonylphenoxy)heptyl]-3-methylisoxazole, according to claim 7.
Claim 10
Dependent Claim
5 words
5-[5-(4-Ethoxycarbonylphenoxy)pentyl]-3-methylisoxazole, according to claim 7.
Claim 11
Dependent Claim
5 words
5-[6-(4-Ethoxycarbonylphenoxy)hexyl]-3-methylisoxazole, according to claim 7.
Claim 12
Dependent Claim
5 words
5-[8-(4-Ethoxycarbonylphenoxy)octyl]-3-methylisoxazole, according to claim 7.
Claim 13
Dependent Claim
5 words
5-[7-(4-Isopropyloxycarbonylphenoxy)heptyl]-3-methylisoxazole, according to claim 7.
Claim 14
Dependent Claim
5 words
5-[7-(4-Propyloxycarbonylphenoxy)heptyl]-3-methylisoxazole, according to claim 7.
Claim 15
Dependent Claim
10 words
A compound according to claim 1 having the formula ##STR7##
Claim 16
Dependent Claim
14 words
A compound according to claim 14 wherein R is methyl and Ar is 2-chloro-4-methoxyphenyl.
Claim 17
Dependent Claim
5 words
3-[5-(2-Chloro-4-methoxyphenoxy)pentyl]-5-methylisoxazole, according to claim 15.
Claim 18
Dependent Claim
28 words
A composition for combatting viruses which comprises an antivirally effective amount of at least one compound according to claim 1 in admixture with a suitable carrier or diluent.
Claim 19
Dependent Claim
13 words
A composition according to claim 17 wherein the antivirally effective compound is 5-[7-(2-chloro-4-methoxyphenoxy)heptyl]-3-methylisoxazole.
Claim 20
Dependent Claim
20 words
A method for combatting viruses which comprises contacting the locus of said viruses with a composition according to claim 17.
Claim 21
Dependent Claim
16 words
A method according to claim 19 wherein said composition contains as the antivirally effective compound 5-[7-(2-chloro-4-methoxyphenoxy)heptyl]-3-methylisoxazole.
References Cited (Backward Citations)
US4268678A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-05-29 | 1987-11-28 | 1988-05-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-05-29 | 1991-11-28 | 1992-05-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-05-29 | 1995-11-28 | 1996-05-29 | $7700.00 | Window Closed / Lapsed |