US4451447A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical formulations
Assignee: Bristol Myers Co
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Filing: 1981-12-24
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Granted: 1984-05-29
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Expires: 2001-12-24
Abstract
Abstract Stable concentrated solutions of cisplatin in a solvent comprising polyethylene glycol or methoxy polyethylene glycol, or a mixture thereof, plus water and a nontoxic pharmaceutically acceptable source of chloride ion.
Inventors
- 👤 Murray A. Kaplan
- 👤 Alphonse P. Granatek
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 01:57
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K33/00; A61K33/24; A61K33/243; A61K47/00; A61K47/06; A61K47/08; A61K47/10
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
65 words
A sterile, stable, concentrated solution of cisplatin in a sealed container, said solution containing from about 10 to about 15 mg of cisplatin per ml and from about 10 to about 15 mg of NaCl per ml in a solvent medium consisting of about 90% of a polyethylene glycol having an average molecular weight of from about 350 to about 450 and about 10% water.
Claim 2
Dependent Claim
65 words
A sterile, stable, concentrated solution of cisplatin in a sealed container, said solution containing from about 10 to about 15 mg of cisplatin per ml and from about 10 to about 15 mg of NaCl per ml in a solvent medium consisting of about 90% of a polyethylene glycol having an average molecular weight of from about 350 to about 450 and about 10% water.
Claim 3
Dependent Claim
75 words
A sterile, stable, concentrated solution of cisplatin in a sealed container, said solution containing from about 10 to about 15 mg of cisplatin per ml and from about 10 to about 15 mg of NaCl per ml in a solvent medium consisting of about 90% of a polyethylene glycol having an average molecular weight of from about 350 to about 450 and about 10% dilute hydrochloric acid having a concentration up to about 0.5 N.
Claim 4
Dependent Claim
75 words
A sterile, stable, concentrated solution of cisplatin in a sealed container, said solution containing from about 10 to about 15 mg of cisplatin per ml and from about 10 to about 15 mg of NaCl per ml in a solvent medium consisting of about 90% of a polyethylene glycol having an average molecular weight of from about 350 to about 450 and about 10% dilute hydrochloric acid having a concentration up to about 0.5 N.
Claim 5
Dependent Claim
100 words
A stable, concentrated solution of cisplatin in a solvent medium comprising from about 85% to about 95% polyethylene glycol having an average molecular weight of from about 350 to about 450 and from about 5% to about 15% water, said solution also containing a source of chloride ion selected from the group consisting of hydrochloric acid, sodium chloride and a mixture thereof, in an amount which is in the range of from about two to about seven equivalents per equivalent of cisplatin in the solution, and said solution having a cisplatin concentration of from about 5 to about 20 mg/ml.
Claim 6
Dependent Claim
100 words
A stable, concentrated solution of cisplatin in a solvent medium comprising from about 85% to about 95% polyethylene glycol having an average molecular weight of from about 350 to about 450 and from about 5% to about 15% water, said solution also containing a source of chloride ion selected from the group consisting of hydrochloric acid, sodium chloride and a mixture thereof, in an amount which is in the range of from about two to about seven equivalents per equivalent of cisplatin in the solution, and said solution having a cisplatin concentration of from about 5 to about 20 mg/ml.
References Cited (Backward Citations)
GB2021996A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-05-29 | 1987-11-28 | 1988-05-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-05-29 | 1991-11-28 | 1992-05-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-05-29 | 1995-11-28 | 1996-05-29 | $7700.00 | Window Closed / Lapsed |