Abstract The present invention provides a process for the preparation of an antacid material based upon magnesium aluminium hydroxide, wherein magnesium hydroxide and/or magnesium oxide is reacted in an atomic ratio of magnesium to aluminium of 1:1 to 3:1 with an aqueous solution of aluminium sulphate until the pH of the reaction mixture is from 4.0 to 8.0, whereafter water-soluble components are removed from the mixture in a known manner and the mixture is isolated and, if desired, dried or preferably the mixture obtained after centrifuging or filtering off is used without further purification and optionally dried. The present invention also provides pharmaceutical compositions containing an antacid material prepared by these processes, in admixture with a conventional pharmaceutical adjuvant. Furthermore, the present invention provides a method of combating hyperacidity and gastrointestinal diseases, which comprises administering an antacid material prepared by the above processes.
A process for the preparation of an antacid material based upon magnesium aluminium hydroxide, wherein magnesium hydroxide and/or magnesium oxide is reacted in an atomic ratio of magnesium to aluminium of 1:1 to 3:1 with an aqueous solution of aluminium sulphate until the pH of the reaction mixture is from 4.0 to 8.0 whereafter water-soluble components are removed from the mixture by centrifugation or filtration and the isolated mixture, if desired, dried.
Claim 2
Dependent Claim
72 words
A process for the preparation of an antacid material based upon magnesium aluminium hydroxide, wherein magnesium hydroxide and/or magnesium oxide is reacted in an atomic ratio of magnesium to aluminium of 1:1 to 3:1 with an aqueous solution of aluminium sulphate until the pH of the reaction mixture is from 4.0 to 8.0 whereafter water-soluble components are removed from the mixture by centrifugation or filtration and the isolated mixture, if desired, dried.
Claim 3
Dependent Claim
23 words
A process according to claim 1, wherein the mixture obtained after centrifuging or filtering off is used without further purification and optionally dried.
Claim 4
Dependent Claim
24 words
A process according to claim 1, wherein the starting materials are used in an atomic ratio of magnesium to aluminium of 1.3:1 to 2:1.
Claim 5
Dependent Claim
25 words
A process according to claim 1 or 3, wherein the reaction is terminated when the pH of the reaction mixture is from 5.0 to 7.0.
Claim 6
Dependent Claim
24 words
A process according to claims 1, 3 or 4, wherein the reaction is carried out at a temperature which does not exceed 60° C.