US4442127A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Naphthoquinone anti-psoriatic agents
Assignee: Syntex USA LLC
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Filing: 1983-01-19
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Granted: 1984-04-10
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Expires: 2003-01-19
Abstract
Abstract Psoriasis in mammals is relieved by topically administering naphthoquinones of the formula: <IMAGE> (I) wherein: R1 and R2 are lower alkoxy; and R3 is halo or cyano.
Inventors
- 👤 Gordon H. Jones
- 👤 John M. Young
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-10 00:59
CPC Classifications
C; C07; C07C; C07C50/00; C07C50/26; C07C50/32; C07C17/00; C07C17/093; C07C17/10; C07C17/14; C07C45/00; C07C45/51; C07C45/54; C07C46/00
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
56 words
A composition in a form for topical administration to mammals for relieving the condition of psoriasis which comprises a pharmaceutically acceptable, non-toxic carrier and a psoriasis-relieving amount of a compound of the formula ##STR7## where R 1 and R 2 are lower alkoxy of one to six carbon atoms and R 3 is halo or cyano.
Claim 2
Dependent Claim
56 words
A composition in a form for topical administration to mammals for relieving the condition of psoriasis which comprises a pharmaceutically acceptable, non-toxic carrier and a psoriasis-relieving amount of a compound of the formula ##STR7## where R 1 and R 2 are lower alkoxy of one to six carbon atoms and R 3 is halo or cyano.
Claim 3
Dependent Claim
33 words
The composition according to claim 1 wherein said compound is ##STR8## wherein R 1 and R 2 are lower alkoxy of one to six carbon atoms and R 3 is halo or cyano.
Claim 4
Dependent Claim
14 words
The composition according to claim 2 where R 3 is fluoro, chloro or bromo.
Claim 5
Dependent Claim
11 words
The composition according to claim 2 wherein R 3 is cyano.
Claim 6
Dependent Claim
10 words
A composition of claim 3 wherein said compound is 6-chloro-2,3-dimethoxy-1,4-naphthoquinone.
Claim 7
Dependent Claim
10 words
A composition of claim 3 wherein said compound is 6-chloro-2,3-di-n-butoxy-1,4-naphthoquinone.
Claim 8
Dependent Claim
26 words
A compound of the formula ##STR9## wherein R 1 and R 2 are lower alkoxy of one to six carbon atoms and R 3 is cyano.
Claim 9
Dependent Claim
26 words
A compound of the formula ##STR9## wherein R 1 and R 2 are lower alkoxy of one to six carbon atoms and R 3 is cyano.
Claim 10
Dependent Claim
21 words
A compound of the formula ##STR10## wherein R 1 and R 2 are lower alkoxy of one to six carbon atoms.
Claim 11
Dependent Claim
21 words
A compound of the formula ##STR10## wherein R 1 and R 2 are lower alkoxy of one to six carbon atoms.
Claim 12
Dependent Claim
8 words
A compound of claim 8 which is 6-chloro-2,3-dimethoxy-1,4-naphthoquinone.
Claim 13
Dependent Claim
8 words
A compound of claim 8 which is 6-chloro-2,3-di-n-butoxy-1,4-naphthoquinone.
Claim 14
Independent Claim
49 words
A method for relieving the condition of psoriasis which comprises topically administering to mammals in need thereof an effective amount of a compound of the formula ##STR11## wherein R 1 and R 2 are lower alkoxy of one to six carbon atoms and R 3 is halo or cyano.
Claim 15
Independent Claim
49 words
A method for relieving the condition of psoriasis which comprises topically administering to mammals in need thereof an effective amount of a compound of the formula ##STR11## wherein R 1 and R 2 are lower alkoxy of one to six carbon atoms and R 3 is halo or cyano.
Claim 16
Independent Claim
42 words
A method for relieving the condition of psoriasis which comprises topically administering to mammals in need thereof an effective amount of a compound of the formula ##STR12## wherein R 1 and R 2 are lower alkoxy of one to six carbon atoms.
Claim 17
Independent Claim
42 words
A method for relieving the condition of psoriasis which comprises topically administering to mammals in need thereof an effective amount of a compound of the formula ##STR12## wherein R 1 and R 2 are lower alkoxy of one to six carbon atoms.
Claim 18
Dependent Claim
14 words
A method according to claim 12 wherein R 1 and R 2 are methoxy.
Claim 19
Dependent Claim
14 words
A method according to claim 12 wherein R 1 and R 2 are n-butoxy.
References Cited (Backward Citations)
US3914264A
Cited
US4229478A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-04-10 | 1987-10-10 | 1988-04-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-04-10 | 1991-10-10 | 1992-04-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-04-10 | 1995-10-10 | 1996-04-10 | $7700.00 | Window Closed / Lapsed |