US4441486A
Expired / Lapsed
US
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Hyperthermia system
Assignee: Leland Stanford Junior University
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Filing: 1981-10-27
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Granted: 1984-04-10
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Expires: 2001-10-27
Abstract
Abstract An ultrasonic hyperthermia system capable of producing discrete heating of a volume of deep-seated, normally perfused tissue. An individual transducer is configured and driven so that its compressional mode of vibration is suppressed near the center, with the result that the near field is characterized by the substantial absence of a strong central (on-axis) peak. This is preferably accomplished by driving the transducer at a frequency such that the transverse mode of vibration is responsible for the suppression. The near field transverse intensity distribution is further characterized by an annular satellite peak that surrounds the axis. As one proceeds axially away from the transducer, the satellite peak decreases and a predominant central peak occurs. A plurality of transducers are mounted in an isospherical configuration so that the corresponding plurality of beams are directed toward a central axis of the system. Simultaneous heating of a relatively large cylindrical region is achieved in a system wherein the beams do not actually cross one another, but rather are offset with respect to the central axis. As the beams approach each other, portions of their satellite peaks add to heat the central portion of the cylindrical region while the central peaks heat the outer portion. In the region where the beams converge, the central peaks concentrate the power within the heated cylindrical region.
Inventors
- 👤 Douglas W. Pounds
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:42
CPC Classifications
G; G10; G10K; G10K11/00; G10K11/18; G10K11/26; G10K11/34; A; A61; A61N; A61N7/00; A61N7/02; A61B; A61B17/00; A61B17/22; A61B17/22004; A61B2017/22027; A61B2017/22028
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
112 words
A method of ultrasonically heating a subject volume comprising the steps of: providing a transducer; acoustically coupling a surface of the transducer to the subject volume; and exciting vibrations within the transducer so that compressional mode vibrations are suppressed over a generally central region of the surface; the suppression of compressional mode vibrations providing an intensity pattern characterized by relatively low intensities in the regions of the subject volume at depths extending out to a transition distance, with a relatively high intensity on-axis peak in a region beyond the transition distance whereupon a discrete portion of the subject volume may be subjected to considerable heating without appreciable heating of the intervening portions.
Claim 2
Independent Claim
112 words
A method of ultrasonically heating a subject volume comprising the steps of: providing a transducer; acoustically coupling a surface of the transducer to the subject volume; and exciting vibrations within the transducer so that compressional mode vibrations are suppressed over a generally central region of the surface; the suppression of compressional mode vibrations providing an intensity pattern characterized by relatively low intensities in the regions of the subject volume at depths extending out to a transition distance, with a relatively high intensity on-axis peak in a region beyond the transition distance whereupon a discrete portion of the subject volume may be subjected to considerable heating without appreciable heating of the intervening portions.
Claim 3
Dependent Claim
54 words
The method of claim 1 wherein said exciting step includes the substeps of: exciting compressional and transverse modes of vibration within the transducer; and selecting the frequency of vibration relative to the transducer size and velocity properties such that the transverse mode reduces the compressional vibration over the generally central region of the surface.
Claim 4
Dependent Claim
26 words
The method of claim 2, and further comprising the step of modulating the frequency over a range including the selected frequency to compensate for transducer imperfections.
Claim 5
Independent Claim
121 words
A method of ultrasonically heating a discrete region within a subject volume at a substantial depth therein comprising the steps of: providing a transducer; acoustically coupling a surface of the transducer to the subject volume; and exciting compressional vibrations over a generally annular region of the area for propagation into the subject volume; the dimensions of the annular region and the wavelength of ultrasonic vibrations within the subject volume defining a transition distance such that the transverse intensity distributions within the subject volume at depths greater than the transition distance display central high intensity peaks while the transverse intensity distributions within the subject volume at depths less than the transition distance are characterized by the substantial reduction of high peak intensities.
Claim 6
Independent Claim
121 words
A method of ultrasonically heating a discrete region within a subject volume at a substantial depth therein comprising the steps of: providing a transducer; acoustically coupling a surface of the transducer to the subject volume; and exciting compressional vibrations over a generally annular region of the area for propagation into the subject volume; the dimensions of the annular region and the wavelength of ultrasonic vibrations within the subject volume defining a transition distance such that the transverse intensity distributions within the subject volume at depths greater than the transition distance display central high intensity peaks while the transverse intensity distributions within the subject volume at depths less than the transition distance are characterized by the substantial reduction of high peak intensities.
Claim 7
Dependent Claim
65 words
The method of claim 4 wherein said providing step comprises the step of providing a transducer having a contiguous surface including the annular surface region and further including a central region, and wherein said exciting step comprises the substeps of exciting compressional vibrations over the annular region and the central region and inducing transverse mode vibrations to suppress the compressional vibrations in the central region.
Claim 8
Dependent Claim
152 words
Apparatus for ultrasonically heating a subject volume comprising: a transducer; means for acoustically coupling a surface of said transducer to said subject volume; and electrical drive means for applying an alternating voltage to said transducer, thereby exciting vibrations within said transducer so that compressional mode vibrations are induced in said transducer and propagated into said subject volume; said drive means being operable to apply said alternating voltage at a frequency which causes the compressional mode vibrations to be suppressed over a generally central region of the surface, the suppression of compressional mode vibrations providing an intensity distribution characterized by relatively low intensities in the regions of said subject volume at depths extending out to a transition distance, with a relatively high intensity on-axis peak in a region beyond said transition distance whereupon a discrete portion of said subject volume may be subjected to considerable heating without appreciable heating of the intervening portions.
Claim 9
Dependent Claim
152 words
Apparatus for ultrasonically heating a subject volume comprising: a transducer; means for acoustically coupling a surface of said transducer to said subject volume; and electrical drive means for applying an alternating voltage to said transducer, thereby exciting vibrations within said transducer so that compressional mode vibrations are induced in said transducer and propagated into said subject volume; said drive means being operable to apply said alternating voltage at a frequency which causes the compressional mode vibrations to be suppressed over a generally central region of the surface, the suppression of compressional mode vibrations providing an intensity distribution characterized by relatively low intensities in the regions of said subject volume at depths extending out to a transition distance, with a relatively high intensity on-axis peak in a region beyond said transition distance whereupon a discrete portion of said subject volume may be subjected to considerable heating without appreciable heating of the intervening portions.
Claim 10
Dependent Claim
12 words
The invention of claim 6 wherein said transducer surface is substantially flat.
Claim 11
Dependent Claim
23 words
The invention of claim 6, and further comprising means for modulating the output frequency of said drive means over a range of frequencies.
Claim 12
Dependent Claim
148 words
Apparatus for ultrasonically heating a discrete region within a subject volume at a substantial depth therein comprising: a plurality of transducer assemblies, each of said transducer assemblies comprising a transducer adapted to be acoustically coupled to said subject volume, and associated drive means for exciting ultrasonic vibrations within said transducer so that when said transducer is acoustically coupled to said subject volume, the vibrations of said transducer cause ultrasonic waves to be propagated into said subject volume, said ultrasonic waves being characterized by an intensity pattern wherein the intensity is relatively low in the regions of the subject volume at depths extending out to a transition distance and wherein the transverse intensity distributions in the regions beyond the transition distance have relatively high intensity peaks; and means for orienting said transducers so that their axes converge toward a central axis into a small region in said subject volume.
Claim 13
Dependent Claim
148 words
Apparatus for ultrasonically heating a discrete region within a subject volume at a substantial depth therein comprising: a plurality of transducer assemblies, each of said transducer assemblies comprising a transducer adapted to be acoustically coupled to said subject volume, and associated drive means for exciting ultrasonic vibrations within said transducer so that when said transducer is acoustically coupled to said subject volume, the vibrations of said transducer cause ultrasonic waves to be propagated into said subject volume, said ultrasonic waves being characterized by an intensity pattern wherein the intensity is relatively low in the regions of the subject volume at depths extending out to a transition distance and wherein the transverse intensity distributions in the regions beyond the transition distance have relatively high intensity peaks; and means for orienting said transducers so that their axes converge toward a central axis into a small region in said subject volume.
Claim 14
Dependent Claim
22 words
The invention of claim 9 wherein said small region is near the transition distance corresponding to at least one of said transducers.
Claim 15
Dependent Claim
74 words
The invention of claim 9 wherein the intensity pattern for each of said transducers is such that the transverse intensity distributions at depths extending out to the transition distance show pronounced satellite peaks, and wherein said orienting means directs the transducer axes such that each transducer axis passes but does not cross the central axis, the cooperation of said satellite peaks and said central peaks causing heating of a volume surrounding said small region.
Claim 16
Dependent Claim
42 words
The invention of claim 9 wherein the transition distances for said transducers are substantially equal, wherein said small region includes a common point of convergence for localized heating, and wherein said transducers are mounted at generally equal distances from said common point.
Claim 17
Dependent Claim
40 words
The invention of claim 9 wherein each of said transducer assemblies is configured to produce compressional vibrations over a generally annular region of the transducer in order to suppress high intensity peaks at depths extending out to said transition distance.
Claim 18
Dependent Claim
20 words
The invention of claim 9 wherein each of said transducers has a flat surface for coupling to said subject volume.
Claim 19
Dependent Claim
23 words
The invention of claim 9 wherein said orienting means comprises: a concave plate; and means for mounting said transducers to said concave plate.
Claim 20
Independent Claim
145 words
A method of ultrasonically heating a discrete region within a subject volume at a substantial depth therein comprising steps of: providing a plurality of transducer assemblies, each transducer assembly having an associated transducer; acoustically coupling a surface of each of the transducers to the subject volume; exciting vibrations within each transducer so that compressional mode vibrations are suppressed over a generally central region of the surface of each transducer; the suppression of compressional mode vibrations providing an intensity pattern characterized by relatively low intensities in the regions of the subject volume at depths extending out to a transition distance and further characterized by transverse intensity distributions beyond the transition distance exhibiting relatively high intensity peaks; and orienting said transducers so that the respective axes of the respective directions of vibration propagation generally converge toward a central axis into a small region within the subject volume.
Claim 21
Independent Claim
145 words
A method of ultrasonically heating a discrete region within a subject volume at a substantial depth therein comprising steps of: providing a plurality of transducer assemblies, each transducer assembly having an associated transducer; acoustically coupling a surface of each of the transducers to the subject volume; exciting vibrations within each transducer so that compressional mode vibrations are suppressed over a generally central region of the surface of each transducer; the suppression of compressional mode vibrations providing an intensity pattern characterized by relatively low intensities in the regions of the subject volume at depths extending out to a transition distance and further characterized by transverse intensity distributions beyond the transition distance exhibiting relatively high intensity peaks; and orienting said transducers so that the respective axes of the respective directions of vibration propagation generally converge toward a central axis into a small region within the subject volume.
Claim 22
Dependent Claim
22 words
The invention of claim 16 wherein said small region is near the transition distance corresponding to at least one of the transducers.
Claim 23
Dependent Claim
28 words
The method of claim 16 wherein said exciting step is carried out such that the transverse intensity distributions at depths less than the transition distance exhibit satellite peaks.
Claim 24
Dependent Claim
29 words
The method of claim 18 wherein said orienting step is carried out so that the respective axes pass but do not cross the central axis in the small region.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-04-10 | 1987-10-10 | 1988-04-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-04-10 | 1991-10-10 | 1992-04-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-04-10 | 1995-10-10 | 1996-04-10 | $7700.00 | Window Closed / Lapsed |