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US4440932A
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7β-Arylalkyl-7α-methyl-6-oxo or 6α-hydroxy-3-methoxy or 3-hydroxy-4,5α-epoxy-17-methyl or 17-cycloalkyl-methylmorphinans
Assignee: Bayer Corp
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Filing: 1982-09-09
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Granted: 1984-04-03
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Expires: 2002-09-09
Abstract
Abstract Disclosed are 7β-arylalkyl-7α-methyl-6-oxo or 6α-hydroxy-3-methoxy or 3-hydroxy-4,5α-epoxy-17-methyl or 17-cycloalkylmethyl-morphinans of the formula: ##STR1## wherein R is H or methyl, X is oxo or α-hydroxy, n is 2 to 4 and R 1 is methyl, cyclopropylmethyl or cyclobutylmethyl. These compounds are useful as strong analgesics.
Inventors
- 👤 Michael P. Kotick
- 👤 David L. Leland
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 08:17
CPC Classifications
C; C07; C07D; C07D489/00; C07D489/02
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
35 words
7β-arylalkyl-7α-methyl-6-oxo or 6α-hydroxy-3-methoxy or 3-hydroxy-4,5α-epoxy-17-methyl or 17-cycloalkylmethyl-morphinans of the formula: ##STR8## wherein R is H or methyl, X is oxo or α-hydroxy, n is 2 to 4 and R 1 is methyl, cyclopropylmethyl or cyclobutylmethyl.
Claim 2
Dependent Claim
35 words
7β-arylalkyl-7α-methyl-6-oxo or 6α-hydroxy-3-methoxy or 3-hydroxy-4,5α-epoxy-17-methyl or 17-cycloalkylmethyl-morphinans of the formula: ##STR8## wherein R is H or methyl, X is oxo or α-hydroxy, n is 2 to 4 and R 1 is methyl, cyclopropylmethyl or cyclobutylmethyl.
Claim 3
Dependent Claim
22 words
A compound as defined by claim 1 wherein R is methyl, X is α-hydroxy, n is 4 and R 1 is cyclopropylmethyl.
Claim 4
Dependent Claim
22 words
A compound as defined in claim 1 wherein R is methyl, X is α-hydroxy, n is 2 and R 1 is cyclobutylmethyl.
Claim 5
Dependent Claim
22 words
A compound as defined by claim 1 wherein R is methyl, X is oxo, n is 2 and R 1 is cyclobutylmethyl.
Claim 6
Dependent Claim
22 words
A compound as defined by claim 1 wherein R is H, X is oxo, n is 4 and R 1 is cyclopropylmethyl.
Claim 7
Dependent Claim
22 words
A compound as defined by claim 1 wherein R is H, X is oxo, n is 2 and R 1 is cyclobutylmethyl.
Claim 8
Dependent Claim
22 words
A compound as defined by claim 1 wherein R is H, X is oxo, n is 4 and R 1 is cyclobutylmethyl.
Claim 9
Dependent Claim
22 words
A compound as defined by claim 1 wherein R is methyl, X is α-hydroxy, n is 4 and R 1 is methyl.
Claim 10
Dependent Claim
22 words
A compound as defined by claim 1 wherein R is methyl, X is oxo, n is 4 and R 1 is methyl.
Claim 11
Dependent Claim
22 words
A compound as defined by claim 1 wherein R is H, X is oxo, n is 4 and R 1 is methyl.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-04-03 | 1987-10-03 | 1988-04-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-04-03 | 1991-10-03 | 1992-04-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-04-03 | 1995-10-03 | 1996-04-03 | $7700.00 | Window Closed / Lapsed |