Fluorinated pentene diamine derivatives

Abstract

Abstract Fluorinated alkenylene diamine compounds are inhibitors of ornithine decarboxylase enzyme in vivo and have the following formula: <IMAGE> wherein: Ra represents hydrogen or R2, where R2 is as defined below; Rb represents hydrogen or, when Ra is hydrogen, R2, where R2 is as defined below; Rc represents hydrogen or -COR3, where R3 is as defined below; R1 represents hydrogen or C1-C6 alkyl; each R2, independently, represents C2-C5 alkylcarbonyl, phenylcarbonyl, phenyl-(C1-C4 alkyl) carbonyl, or an aminocarboxylic acid residue derived by removal of an hydroxy group from a carboxy moiety of an L-aminocarboxylic acid; R3 represents hydroxy, or, when Ra and Rb are both hydrogen, C1-C8 alkoxy, -NR4R5, where R4 and R5 are as defined below, or an aminocarboxylic acid residue derived by removal of an hydrogen atom from the amino moiety of an L-aminocarboxylic acid; R4 and R5, independently, represent hydrogen or C1-C4 alkyl; and p represents 1 or 2.

Inventors

• 👤 Philippe Bey
• 👤 Fritz Gerhart
• 👤 Michel Jung

Bibliographic Details