US4439414A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1-11 C-D-Glucose and related compounds
Assignee: ENERGY United States, Department of
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Filing: 1982-01-26
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Granted: 1984-03-27
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Expires: 2002-01-26
Abstract
Abstract The novel compounds 1- 11 C-D-glucose, 1- 11 C-D-mannose, 1- 11 C-D-galactose, 2- 11 C-D-glucose, 2- 11 C-D-mannose and 2- 11 C-D-galactose which can be used in nuclear medicine to monitor the metabolism of glucose and galactose can be rapidly prepared by reaction of the appropriate aldose substrate with an alkali metal 11 C-labeled cyanide followed by reduction with a Raney alloy in formic acid.
Inventors
- 👤 Chyng-Yann Shiue
- 👤 Alfred P. Wolf
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 19:13
CPC Classifications
A; A61; A61K; A61K51/00
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
28 words
A novel radiopharmaceutical selected from the group consisting of 1- 11 C-D-glucose, 2- 11 C-D-glucose, 1- 11 C-D-mannose, 2- 11 C-D-mannose, 1- 11 C-D-galactose and 2- 11 C-D-galactose.
Claim 2
Dependent Claim
28 words
A novel radiopharmaceutical selected from the group consisting of 1- 11 C-D-glucose, 2- 11 C-D-glucose, 1- 11 C-D-mannose, 2- 11 C-D-mannose, 1- 11 C-D-galactose and 2- 11 C-D-galactose.
Claim 3
Dependent Claim
15 words
A compound selected from the group consisting of 1- 11 C-D-arabinose and 1- 11 C-D-lyxose.
Claim 4
Dependent Claim
15 words
A compound selected from the group consisting of 1- 11 C-D-arabinose and 1- 11 C-D-lyxose.
Claim 5
Independent Claim
241 words
A method for the preparation of a compound selected from the group consisting of 1- 11 C-D-glucose, 2- 11 C-D-glucose, 1- 11 C-D-mannose, 2- 11 C-D-mannose, 1- 11 C-D-galactose and 2- 11 C-D-galactose which comprises: (1) for the production of 1- 11 C-D-glucose and 1- 11 C-D-mannose reacting D-arabinose, and for the production of 1- 11 C-D-galactose reacting D-lyxose respectively with an alkali metal cyanide having an 11 C label in an aqueous media at pH 7.5 to 9, reducing resulting cyano compounds with Raney alloy and separating the desired D-glucose and D-mannose compounds from the mixture resulting from the use of D-arabinose as the starting compound and the desired D-galactose from mixture resulting from the use of D-lyxose as the starting compound; and (2) for the production of 2- 11 C-D-glucose or 2- 11 C-D-mannose reacting D-erythrose or for the production of 2- 11 C-galactose reacting D-threose respectively with an alkali metal cyanide having an 11 C label in an aqueous media at pH 7.5 to 9, reducing resulting cyano compounds with Raney alloy and separating 1- 11 C-D-arabinose from the mixture resulting from the use of D-erythrose as the starting compound and 1- 11 C-D-lyxose from the mixture resulting from the use of D-threose as the starting compound, and repeating the same reactions on the said 1- 11 C-D-arabinose and 1- 11 C-D-lyxose except for the use of an alkali metal cyanide with the 12 C isotope of carbon.
Claim 6
Independent Claim
241 words
A method for the preparation of a compound selected from the group consisting of 1- 11 C-D-glucose, 2- 11 C-D-glucose, 1- 11 C-D-mannose, 2- 11 C-D-mannose, 1- 11 C-D-galactose and 2- 11 C-D-galactose which comprises: (1) for the production of 1- 11 C-D-glucose and 1- 11 C-D-mannose reacting D-arabinose, and for the production of 1- 11 C-D-galactose reacting D-lyxose respectively with an alkali metal cyanide having an 11 C label in an aqueous media at pH 7.5 to 9, reducing resulting cyano compounds with Raney alloy and separating the desired D-glucose and D-mannose compounds from the mixture resulting from the use of D-arabinose as the starting compound and the desired D-galactose from mixture resulting from the use of D-lyxose as the starting compound; and (2) for the production of 2- 11 C-D-glucose or 2- 11 C-D-mannose reacting D-erythrose or for the production of 2- 11 C-galactose reacting D-threose respectively with an alkali metal cyanide having an 11 C label in an aqueous media at pH 7.5 to 9, reducing resulting cyano compounds with Raney alloy and separating 1- 11 C-D-arabinose from the mixture resulting from the use of D-erythrose as the starting compound and 1- 11 C-D-lyxose from the mixture resulting from the use of D-threose as the starting compound, and repeating the same reactions on the said 1- 11 C-D-arabinose and 1- 11 C-D-lyxose except for the use of an alkali metal cyanide with the 12 C isotope of carbon.
Claim 7
Dependent Claim
18 words
The method according to claim 3 utilizing sodium cyanide labeled with the 11 C isotope at pH 8.
Claim 8
Independent Claim
44 words
A method for the diagnostic measurement of glucose metabolism wherein a diagnostically effective amount of a compound selected from the group consisting of 1- 11 C-D-glucose, 2- 11 C-D-glucose, 1- 11 C-D-mannose and 2- 11 C-D-mannose is injected into a patient and subsequently imaged.
Claim 9
Independent Claim
44 words
A method for the diagnostic measurement of glucose metabolism wherein a diagnostically effective amount of a compound selected from the group consisting of 1- 11 C-D-glucose, 2- 11 C-D-glucose, 1- 11 C-D-mannose and 2- 11 C-D-mannose is injected into a patient and subsequently imaged.
Claim 10
Independent Claim
38 words
A method for the diagnostic measurement of galactose metabolism wherein a diagnostically effective amount of a compound selected from the group consisting of 1- 11 C-D-galactose and 2- 11 D-galactose is injected into a patient and subsequently imaged.
Claim 11
Independent Claim
38 words
A method for the diagnostic measurement of galactose metabolism wherein a diagnostically effective amount of a compound selected from the group consisting of 1- 11 C-D-galactose and 2- 11 D-galactose is injected into a patient and subsequently imaged.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-03-27 | 1987-09-26 | 1988-03-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-03-27 | 1991-09-26 | 1992-03-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-03-27 | 1995-09-26 | 1996-03-27 | $7700.00 | Window Closed / Lapsed |