US4439359A
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Cyclic octapeptide analogs of neurotensin
Assignee: Merck and Co Inc
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Filing: 1982-07-02
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Granted: 1984-03-27
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Expires: 2002-07-02
Abstract
Abstract There are disclosed cyclic octapeptide analogs of the tridecapeptide, neurotensin.
Inventors
- 👤 Frederick W. Holly, deceased
- 👤 Marcia E. Christy
- 👤 Kenneth L. Shepard
- 👤 Robert G. Strachan
- 👤 Sandor L. Varga
- 👤 Daniel F. Veber
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 11:33
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/04; C07K7/08; C07K7/083; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/27
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
36 words
A cyclic octapeptide having the formula Cyclo(D-Lys-Pro-B-B-Pro-C-Ile-Leu) (I) wherein: B is a basic amino acid residue selected from the group consisting of 2,4-diamino butyric acid, lysine, arginine, ornithine, and homoarginine; and C is tyrosine, or tryptophane.
Claim 2
Dependent Claim
36 words
A cyclic octapeptide having the formula Cyclo(D-Lys-Pro-B-B-Pro-C-Ile-Leu) (I) wherein: B is a basic amino acid residue selected from the group consisting of 2,4-diamino butyric acid, lysine, arginine, ornithine, and homoarginine; and C is tyrosine, or tryptophane.
Claim 3
Dependent Claim
15 words
The octapeptide of claim 1 wherein B is lysine or ornithine; and, C is tyrosine.
Claim 4
Dependent Claim
4 words
The cyclic octapeptide: Cyclo(D-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu).
Claim 5
Dependent Claim
4 words
The cyclic octapeptide: Cyclo(D-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu).
Claim 6
Dependent Claim
4 words
The cyclic octapeptide: Cyclo(D-Lys-Pro-Orn-Orn-Pro-Tyr-Lle-Leu).
Claim 7
Dependent Claim
4 words
The cyclic octapeptide: Cyclo(D-Lys-Pro-Orn-Orn-Pro-Tyr-Lle-Leu).
Claim 8
Dependent Claim
4 words
The cyclic octapeptide: Cyclo(D-Lys-Pro-Lys-Lys-Pro-Tyr-Ile-Leu).
Claim 9
Dependent Claim
4 words
The cyclic octapeptide: Cyclo(D-Lys-Pro-Lys-Lys-Pro-Tyr-Ile-Leu).
Claim 10
Dependent Claim
4 words
The cyclic octapeptide: Cyclo(D-Lys-Pro-Orn-Orn-Pro-Trp-Ile-Leu).
Claim 11
Dependent Claim
4 words
The cyclic octapeptide: Cyclo(D-Lys-Pro-Orn-Orn-Pro-Trp-Ile-Leu).
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-03-27 | 1987-09-26 | 1988-03-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-03-27 | 1991-09-26 | 1992-03-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-03-27 | 1995-09-26 | 1996-03-27 | $7700.00 | Window Closed / Lapsed |