US4438131A
Expired / Lapsed
US
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Ω-Cyano-1, Ω-diphenyl-azaalkane derivatives, their preparation and drugs containing them
Assignee: BASF SE
•
Filing: 1982-03-30
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Granted: 1984-03-20
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Expires: 2002-03-30
Abstract
Abstract ω-Cyano-1,ω-diphenyl-azaalkane derivatives of the formula I ##STR1## where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , m and n have the meanings given in the description, and salts thereof with physiologically tolerated acids, are useful in treating cardiovascular disorders.
Inventors
- 👤 Oskar Ehrmann
- 👤 Manfred Raschack
- 👤 Josef Gries
- 👤 Rolf Kretzschmar
- 👤 Hans D. Lehmann
- 👤 Ludwig Friedrich
- 👤 Dirk Wuppermann
- 👤 Frank Zimmermann
- 👤 Werner Seitz
- 👤 Hans J. Treiber
- 👤 Ferdinand Dengel
- 👤 Wolfram Frank
- 👤 Hans-Georg Kurbjuweit
- 👤 Claus D. Mueller
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 13:57
CPC Classifications
C; C07; C07C; C07C255/00; A; A61; A61P; A61P37/00; A61P37/08; A61P9/00; A61P9/06; A61P9/10; C07D; C07D317/00; C07D317/08; C07D317/44; C07D317/46; C07D317/48; C07D317/50; C07D317/58; C07D317/60; C07D319/00; C07D319/10; C07D319/14; C07D319/16; C07D319/18
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
118 words
An ω-cyano-1,ω-diphenyl-azaalkane derivative of the formula I, ##STR14## where R 1 , R 2 , R 3 , R 6 , R 7 and R 8 are identical or different and each is hydrogen, halogen, hydroxyl, trifluoromethyl, C 1 -C 4 -alkyl, nitro, C 1 -C 4 -alkoxy or C 1 -C 4 -alkylmercapto, and two radicals in adjacent positions can together form a methylenedioxy, ethylenedioxy or 1,3-dioxatetramethylene group, R 4 is straight-chain or branched, saturated or unsaturated alkyl of 9 to 20 carbon atoms, R 5 is hydrogen or C 1 -C 4 -alkyl and m and n are identical or different and each is from 2 to 4, and salts thereof with a physiologically tolerated acid.
Claim 2
Dependent Claim
118 words
An ω-cyano-1,ω-diphenyl-azaalkane derivative of the formula I, ##STR14## where R 1 , R 2 , R 3 , R 6 , R 7 and R 8 are identical or different and each is hydrogen, halogen, hydroxyl, trifluoromethyl, C 1 -C 4 -alkyl, nitro, C 1 -C 4 -alkoxy or C 1 -C 4 -alkylmercapto, and two radicals in adjacent positions can together form a methylenedioxy, ethylenedioxy or 1,3-dioxatetramethylene group, R 4 is straight-chain or branched, saturated or unsaturated alkyl of 9 to 20 carbon atoms, R 5 is hydrogen or C 1 -C 4 -alkyl and m and n are identical or different and each is from 2 to 4, and salts thereof with a physiologically tolerated acid.
Claim 3
Dependent Claim
1 words
1,7-bis-(3-Methoxyphenyl)-3-methylaza-7-cyano-nonadecane.
Claim 4
Dependent Claim
1 words
1,7-bis-(3-Methoxyphenyl)-3-methylaza-7-cyano-nonadecane.
Claim 5
Dependent Claim
1 words
1-(3-Methoxyphenyl)-3-methylaza-7-cyano-7-(3,4-dimethoxyphenyl)-nonadecane.
Claim 6
Dependent Claim
1 words
1-(3-Methoxyphenyl)-3-methylaza-7-cyano-7-(3,4-dimethoxyphenyl)-nonadecane.
Claim 7
Dependent Claim
1 words
1-(3-Methoxyphenyl)-3-methylaza-7-cyano-7-(3,4,5-trimethoxyphenyl)-nonadecane.
Claim 8
Dependent Claim
1 words
1-(3-Methoxyphenyl)-3-methylaza-7-cyano-7-(3,4,5-trimethoxyphenyl)-nonadecane.
Claim 9
Dependent Claim
1 words
1,7-Diphenyl-3-methylaza-7-cyano-nonadecane.
Claim 10
Dependent Claim
1 words
1,7-Diphenyl-3-methylaza-7-cyano-nonadecane.
Claim 11
Dependent Claim
53 words
An ω-cyano-1,ω-diphenyl-azaalkane derivative of the formula I as set forth in claim 1, wherein R 1 , R 2 , R 3 , R 6 , R 7 , and R 8 are hydrogen or alkoxy; R 4 is a straight-chain alkyl of 10 to 14 carbon atoms; and R 5 is methyl.
Claim 12
Dependent Claim
17 words
An ω-cyano-1,ω-diphenyl-azaalkane derivative of the formula I as set forth in claim 1, wherein n+m is 5.
Claim 13
Dependent Claim
17 words
An ω-cyano-1,ω-diphenyl-azaalkane derivative of the formula I as set forth in claim 6, wherein n+m is 5.
Claim 14
Dependent Claim
54 words
An ω-cyano-1,ω-diphenyl-azaalkane derivative of the formula I as set forth in claim 1, wherein R 1 , R 2 , R 3 , R 6 , R 7 , and R 8 , are hydrogen or methoxy; R 4 is a straight-chain alkyl of 10 to 14 carbon atoms; and R 5 is methyl.
Claim 15
Dependent Claim
17 words
An ω-cyano-1,ω-diphenyl-azaalkane derivative of the formula I as set forth in claim 9, where n+m is 5.
Claim 16
Dependent Claim
26 words
An ω-cyano-1,ω-diphenyl-azaalkane derivative of the formula I as set forth in claim 6, wherein R 4 is a straight-chain alkyl of 11 to 13 carbon atoms.
Claim 17
Dependent Claim
17 words
An ω-cyano-1,ω-diphenyl-azaalkane derivative of the formula I as set forth in claim 11, wherein n+m is 5.
Claim 18
Dependent Claim
36 words
An ω-cyano-1,ω-diphenyl-azaalkane derivative of the formula I as set forth in claim 12, wherein R 1 , R 2 , R 3 , R 6 , R 7 , and R 8 are hydrogen or methoxy.
Claim 19
Dependent Claim
31 words
A therapeutic composition for treating cardiovascular disorders comprising a pharmaceutical excipient and an effective amount of an ω-cyano-1,ω-diphenyl-azaalkane derivative of the formula I according to claim 1 as the active ingredient.
Claim 20
Dependent Claim
29 words
The method of treating cardiovascular disorders in a patient suffering therefrom which comprises administering an effective amount of an ω-cyano-1,ω-diphenyl-azaalkane derivative of the formula I according to claim 1.
References Cited (Backward Citations)
CA916719A
Cited
US3261859A
Cited
GB1202500A
Cited
GB1202750A
Cited
GB1367677A
Cited
GB1377209A
Cited
US4305887A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-03-20 | 1987-09-19 | 1988-03-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-03-20 | 1991-09-19 | 1992-03-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-03-20 | 1995-09-19 | 1996-03-20 | $7700.00 | Window Closed / Lapsed |