US4438105A
Expired / Lapsed
US
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4'-Iododerivatives of anthracycline glycosides
Assignee: Pfizer Italia SRL
•
Filing: 1982-04-14
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Granted: 1984-03-20
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Expires: 2002-04-14
Abstract
Abstract Starting from the known 4'-deoxy-4'-iodo-N-trifluoroacetyldaunorubicin, two new anthracycline glycosidic antibiotics, the 4'-deoxy-4'-iodo-daunorubicin and 4'-deoxy-4'-iodo-doxorubicin, have been prepared by known procedures. Both the new glycosides have been found to be endowed with outstanding antitumoral activity.
Inventors
- 👤 Antonino Suarato
- 👤 Sergio Penco
- 👤 Federico Arcamone
- 👤 Anna M. Casazza
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 23:34
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/20; C07H15/24; C07H15/252; A; A61; A61P; A61P35/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
20 words
An anthracycline glycosidic compound of the general formula I. ##STR2## wherein R is a hydrogen atom or a hydroxy group.
Claim 2
Dependent Claim
20 words
An anthracycline glycosidic compound of the general formula I. ##STR2## wherein R is a hydrogen atom or a hydroxy group.
Claim 3
Dependent Claim
9 words
A compound according to claim 1, which is 4'-deoxy-4'-iododaunorubicin.
Claim 4
Dependent Claim
9 words
A compound according to claim 1, which is 4'-deoxy-4'-iododoxorubicin.
Claim 5
Dependent Claim
40 words
A pharmaceutical composition having antitumor activity against a tumor selected from the group consisting of P388 leukemia and gross leukemia comprising a therapeutically effective amount of an anthracycline glycoside according to claim 1 in combination with an inert carrier therefor.
Claim 6
Dependent Claim
43 words
A method of inhibiting the growth of a tumor selected from the group of P388 leukemia or Gross leukemia, said method comprising administering to a host afflicted with said tumor a therapeutically effective amount of an anthracycline glycoside as claimed in claim 1.
References Cited (Backward Citations)
US4303785A
Cited
US4345070A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-03-20 | 1987-09-19 | 1988-03-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-03-20 | 1991-09-19 | 1992-03-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-03-20 | 1995-09-19 | 1996-03-20 | $7700.00 | Window Closed / Lapsed |