US4438100A
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Sterilized preserved, stable mucine-containing solutions
Assignee: Orthana Kemisk Fabrik AS
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Filing: 1981-04-27
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Granted: 1984-03-20
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Expires: 2001-04-27
Abstract
Abstract PCT No. PCT/DK81/00043 Sec. 371 Date Dec. 28, 1981 Sec. 102(e) Date Dec. 28, 1981 PCT Filed Apr. 27, 1981 PCT Pub. No. WO81/02977 PCT Pub. Date Oct. 29, 1981.Sterilized, preserved, stable mucine-containing solutions for use for application to sensitive human mucous membranes of the oral cavity, the nasal system, and the eye ephithel contain an oxidizing bactericide, in particular hydrogen peroxide, as preservative. Even at very small hydrogen peroxide concentrations, solutions remain bactericidal over prolonged periods such as 1-2 years. Mucine used is porcine gastric mucine or bovine salivary mucine or-to adjust the polar/non-polar properties-a mixture of both. The pronounced lubricating effect, combined with suitable viscosity, low surface tension and ability to coat and protect mucous membranes renders the solutions well suited as artificial salivas, ophthalmic solutions, and carriers for medicaments.
Inventors
- 👤 Erik Balslev
- 👤 Svenn S. Hansen
- 👤 Ernst L. Pedersen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 22:59
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/46; C07K14/47; C07K14/4701; C07K14/4727; A; A01; A01N; A01N59/00; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/64; A61K9/00; A61K9/0012; A61K9/0043; A61K9/0048; A61L; A61L2/00; A61L2/16; A61L2/18; A61Q; A61Q11/00; A61K38/00; A61L2103/00; A61L2103/05
Claims Analysis
Total Claims: 31
Claim 1
Independent Claim
79 words
An aqueous mucine-containing composition, in particular for application to human mucous membranes and/or for use as an ophthalmic solution, comprising a non-human mammalian mucine selected from the group consisting of buccal and gastrointestinal mucines, the composition having a viscosity of at the most 50 relative to water, as measured with an Oswald viscosimeter, said composition being sterilized and containing an oxidizing bactericide preservative which is present in a physiologically tolerable concentration with respect to the application of the composition.
Claim 2
Dependent Claim
79 words
An aqueous mucine-containing composition, in particular for application to human mucous membranes and/or for use as an ophthalmic solution, comprising a non-human mammalian mucine selected from the group consisting of buccal and gastrointestinal mucines, the composition having a viscosity of at the most 50 relative to water, as measured with an Oswald viscosimeter, said composition being sterilized and containing an oxidizing bactericide preservative which is present in a physiologically tolerable concentration with respect to the application of the composition.
Claim 3
Dependent Claim
16 words
A composition as claimed in claim 1 which is substantially free from any mucine-decomposing enzymatic activity.
Claim 4
Dependent Claim
40 words
A composition as claimed in claim 1 or 2, in which the bacterial count of the composition remains substantially constant for a period of at least one year when the composition is kept in a closed container at room temperature.
Claim 5
Dependent Claim
45 words
A composition as claimed in claim 3 in which the bacterial count of the composition remains substantially constant when the composition is kept at 4° C. in a container from which a portion of the solution is withdrawn occasionally during a period of two months.
Claim 6
Dependent Claim
16 words
A composition as claimed in claim 1 in which the oxidizing bactericide preservative is a peroxide.
Claim 7
Dependent Claim
24 words
A composition as claimed in claim 1 in which the oxidizing bactericide preservative is present in a concentration of about 0.01-70 millimol per liter.
Claim 8
Dependent Claim
28 words
A composition as claimed in claim 6 wherein the oxidizing bactericide preservative is hydrogen peroxide and is present in an initial concentration of about 10 millimol per liter.
Claim 9
Dependent Claim
20 words
A composition as claimed claim 1 or 2 in which the mucine is porcine gastric mucine and/or bovine salivary mucine.
Claim 10
Dependent Claim
22 words
A composition as claimed in claim 8 in which the mucine is a combination of porcine gastric mucine and bovine salivary mucine.
Claim 11
Dependent Claim
27 words
A composition as claimed in claim 9 wherein the weight ratio between porcine gastric mucine and bovine salivary mucine in the composition is from 1:1000 to 1000:1.
Claim 12
Dependent Claim
24 words
A composition as claimed in claim 10 wherein the weight ratio between porcine gastric mucine and bovine salivary mucine is between 30:1 and 200:1.
Claim 13
Dependent Claim
27 words
A composition as claimed in claim 11 wherein the weight ratio between porcine gastric mucine and bovine salivary mucine is in the range between 100:5 and 100:0.5.
Claim 14
Dependent Claim
21 words
A composition as claimed in claim 1 or 11 in which the mucine content of the solution is 0.2-6% by weight.
Claim 15
Dependent Claim
19 words
A composition as claimed in claim 13 in which the mucine content of the solution is 1-5% by weight.
Claim 16
Dependent Claim
32 words
A composition as claimed in claim 8 for use as an artifical saliva solution, the composition having a viscosity between 2 and 30 relative to water, as measured with an Oswald viscosimeter.
Claim 17
Dependent Claim
17 words
An artificial saliva solution as claimed in claim 15 which has a viscosity between 4 and 10.
Claim 18
Dependent Claim
20 words
An artificial saliva solution as claimed in claims 16 which contains at least one ion species found in human saliva.
Claim 19
Dependent Claim
13 words
An artificial saliva solution as claimed in claim 17 which contains a thiocyanate.
Claim 20
Dependent Claim
25 words
An artificial saliva solution as claimed in claim 18 in which the thiocyanate is present in a concentration of from 0.25 mM to 6 mM.
Claim 21
Dependent Claim
22 words
An artificial saliva solution as claimed in claim 16 which has a surface tension in the range between 40 and 60 dyn.cm.
Claim 22
Dependent Claim
26 words
A sterilized composition comprising a non-human mammalian mucine selected from the group consisting of buccal and gastrointestinal mucines and containing an oxidizing bactericide, as a preservative.
Claim 23
Dependent Claim
26 words
A sterilized composition comprising a non-human mammalian mucine selected from the group consisting of buccal and gastrointestinal mucines and containing an oxidizing bactericide, as a preservative.
Claim 24
Dependent Claim
12 words
A composition as claimed in claim 21 which comprises porcine gastric mucine.
Claim 25
Dependent Claim
12 words
A composition as claimed in claim 21 which comprises bovine salivary mucine.
Claim 26
Dependent Claim
19 words
A composition as claimed in claim 21 which contains a combination of porcine gastric mucine and bovine salivary mucine.
Claim 27
Dependent Claim
27 words
A composition as claimed in claim 24 wherein the weight ratio between porcine gastric mucine and bovine salivary mucine in the composition is from 1:1000 to 1000:1.
Claim 28
Dependent Claim
24 words
A composition as claimed in claim 25 wherein the weight ratio between porcine gastric mucine and bovine salivary mucine is between 30:1 and 200:1.
Claim 29
Dependent Claim
27 words
A composition as claimed in claim 26 wherein the weight ratio between porcine gastric mucine and bovine salivary mucine is in the range between 100:5 and 100:0.5.
Claim 30
Dependent Claim
12 words
A composition as claimed in claim 25 which is an aqueous solution.
Claim 31
Dependent Claim
12 words
A composition as claimed in claim 25 which is a dry composition.
References Cited (Backward Citations)
US2276882A
Cited
US3567821A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-03-20 | 1987-09-19 | 1988-03-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-03-20 | 1991-09-19 | 1992-03-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-03-20 | 1995-09-19 | 1996-03-20 | $7700.00 | Window Closed / Lapsed |