US4436874A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Acrylic copolymers and their use in solid phase peptide synthesis
Assignee: Expansia SA
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Filing: 1982-11-10
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Granted: 1984-03-13
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Expires: 2002-11-10
Abstract
Abstract The present invention relates to new amino-functionalized acrylic copolymers, their preparation and their use in peptide synthesis.
Inventors
- 👤 Christian Aspisi
- 👤 Bernard Calas
- 👤 Jacques Daunis
- 👤 Michel Follet
- 👤 Robert Jacquier
- 👤 Joseph Parello
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 22:48
CPC Classifications
C; C08; C08F; C08F220/00; C08F220/02; C08F220/52; C08F220/54; C08F220/56; B; B01; B01J; B01J39/00; B01J39/08; B01J39/16; B01J39/18; B01J39/20; B01J39/26; C07; C07K; C07K1/00; C07K1/04; C07K1/042; C08F8/00; C08F8/30; C08F8/32
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
140 words
New amino-functionalized acrylic copolymers derived by functionalization by ethylene diamine on R 3 substituent of the copolymers containing: from 30% to 90%, by weight, of a monomer (matrix) corresponding to an N-acryloylpolymethylenimine of formula ##STR12## or a N-acryloyldialkylamide, of formula: ##STR13## with R 1 having the same meaning as above R 2 =--CH 3 or --C 2 H 5 from 2% to 50%, by weight, of a monomer (linker) corresponding to an N,N'-diacryloyldiaminoalcane of formula ##STR14## and from 2% to 65%, by weight, of a monomer (functionalization agent) corresponding to an acryloylaminoacid or ester, racemic of formula: ##STR15## or an asymetric N-acryloylaminoacide (or ester) (L series) of the formula: ##STR16## R 3 having the same meaning as above ##STR17## or the N-acryloyl (L) proline, or its methyl ester of the formula: ##STR18## R 3 having the same meaning as above.
Claim 2
Dependent Claim
140 words
New amino-functionalized acrylic copolymers derived by functionalization by ethylene diamine on R 3 substituent of the copolymers containing: from 30% to 90%, by weight, of a monomer (matrix) corresponding to an N-acryloylpolymethylenimine of formula ##STR12## or a N-acryloyldialkylamide, of formula: ##STR13## with R 1 having the same meaning as above R 2 =--CH 3 or --C 2 H 5 from 2% to 50%, by weight, of a monomer (linker) corresponding to an N,N'-diacryloyldiaminoalcane of formula ##STR14## and from 2% to 65%, by weight, of a monomer (functionalization agent) corresponding to an acryloylaminoacid or ester, racemic of formula: ##STR15## or an asymetric N-acryloylaminoacide (or ester) (L series) of the formula: ##STR16## R 3 having the same meaning as above ##STR17## or the N-acryloyl (L) proline, or its methyl ester of the formula: ##STR18## R 3 having the same meaning as above.
Claim 3
Dependent Claim
20 words
Preparation process of functionalized copolymers of claim 1 wherein the treatment by ethylenediamine is effected between 0° and 25° C.
Claim 4
Dependent Claim
19 words
Process according to claim 2 wherein the reaction is effected in the presence of dicyclohexylcarbodiimide, when R 3 =H.
Claim 5
Dependent Claim
25 words
Process according to claim 2 wherein the reaction is effected in the presence of an excess of anhydrous ethylene, when R 3 =CH 3 .
Claim 6
Dependent Claim
20 words
Process according to claim 2 wherein functionalization degree is comprised between 2 and 5 meq per gram of dry support.
Claim 7
Dependent Claim
26 words
Process according to claim 5 wherein the ratio between the number of N-protected aminoacid mols and functionalization degree of support is comprised between 1.1 and 1.2.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-03-13 | 1987-09-12 | 1988-03-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-03-13 | 1991-09-12 | 1992-03-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-03-13 | 1995-09-12 | 1996-03-13 | $7700.00 | Window Closed / Lapsed |