US4436731A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Semi-synthetic chitin derivative, the process for its preparation, and therapeutic compositions which contain it as active principle
Assignee: Texcontor
•
Filing: 1982-03-31
•
Granted: 1984-03-13
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Expires: 2002-03-31
Abstract
Abstract A new polysaccharide constituted by units of D-glucosammonium salts, prepared from natural chitin. The new product has strong hypocholesterolemic activity.
Inventors
- 👤 Javier E. Maltz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 01:18
CPC Classifications
C; C08; C08B; C08B37/00; C08B37/0006; C08B37/0024; C08B37/0027; C08B37/003
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
34 words
A polysaccharide of formula: ##STR3## in which R is alkyl of 1-6 carbon atoms, n is a whole number between 1000 and 2000, X=Cl, CH 3 OSO 3 - , SO 4 -- .
Claim 2
Dependent Claim
34 words
A polysaccharide of formula: ##STR3## in which R is alkyl of 1-6 carbon atoms, n is a whole number between 1000 and 2000, X=Cl, CH 3 OSO 3 - , SO 4 -- .
Claim 3
Dependent Claim
91 words
A process for preparing a polysaccharide of formula: ##STR4## starting from chitin by deacetylation of chitosan, characterized in that the chitosan is activated by dissolving in acetic acid in the proportion of 10% v/v and reprecipitation with NaOH at a concentration of between 0.5 and 15% w/w, and is then quaternised by treatment with an alkylating agent of formula RX, in which R is alkyl of 1-6 carbon atoms, X=Cl, CH 3 OSO 3 - , SO 4 -- , in an inert organic solvent at a temperature of 40°-90° C.
Claim 4
Dependent Claim
91 words
A process for preparing a polysaccharide of formula: ##STR4## starting from chitin by deacetylation of chitosan, characterized in that the chitosan is activated by dissolving in acetic acid in the proportion of 10% v/v and reprecipitation with NaOH at a concentration of between 0.5 and 15% w/w, and is then quaternised by treatment with an alkylating agent of formula RX, in which R is alkyl of 1-6 carbon atoms, X=Cl, CH 3 OSO 3 - , SO 4 -- , in an inert organic solvent at a temperature of 40°-90° C.
Claim 5
Dependent Claim
49 words
A process as claimed in claim 2, wherein the quaternisation reaction is carried out in an excess of alkyl chloride of formula RCl in which R is alkyl of 1-6 carbon atoms, in sulpholane, at a temperature of 40°-90° C., for a time of between 2 and 24 hours.
Claim 6
Dependent Claim
33 words
A process as claimed in claim 2, wherein the quaternisation reaction is carried out with dimethyl sulphate, in alcoholic solvent, at a temperature of between 20°-30° C., for a time of 1-2 hours.
Claim 7
Dependent Claim
21 words
A therapeutic composition comprising a hypocholesterolemically effective amount of a compound as defined in claim 1 and a pharmaceutically acceptable carrier.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-03-13 | 1987-09-12 | 1988-03-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-03-13 | 1991-09-12 | 1992-03-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-03-13 | 1995-09-12 | 1996-03-13 | $7700.00 | Window Closed / Lapsed |