US4432987A
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Crystalline benzenesulfonate salts of sultamicillin
Assignee: Pfizer Inc
•
Filing: 1982-04-23
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Granted: 1984-02-21
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Expires: 2002-04-23
Abstract
Abstract Novel benzenesulfonic acid addition salts of sultamicillin of the formula <IMAGE> (I) and hydrated forms thereof, where X is hydrogen or chloro, especially the crystalline dihydrate salts, having advantages over the prior art forms of sultamicillin in pharmaceutical dosage forms, most particularly those for use in pediatric medicine, method for their use and pharmaceutical compositions thereof.
Inventors
- 👤 Wayne E. Barth
- 👤 Vytautas J. Jasys
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 13:35
CPC Classifications
C; C07; C07D; C07D499/00; C07D499/21; C07D499/28; C07D499/32; A; A61; A61P; A61P31/00; A61P31/04
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
21 words
A benzenesulfonic acid addition salt of sultamicillin of the formula ##STR4## and hydrated forms thereof, wherein X is hydrogen or chloro.
Claim 2
Dependent Claim
21 words
A benzenesulfonic acid addition salt of sultamicillin of the formula ##STR4## and hydrated forms thereof, wherein X is hydrogen or chloro.
Claim 3
Dependent Claim
8 words
A crystalline dihydrate salt according to claim 1.
Claim 4
Dependent Claim
54 words
The crystalline dihydrate salt according to claim 2 wherein X is hydrogen, having the following X-ray powder diffraction peaks: ______________________________________
Peak, degrees 2 theta
______________________________________
9.3 19.8 30.5
11.4 20.6 31.7
12.2 22.3 33.5
13.4 22.7 34.4
15.5 23.4 35.1
16.2 25.4 36.1
16.9 26.7 37.5
17.1 27.3 38.6
18.3 29.6 44.7
18.9
______________________________________
Claim 5
Dependent Claim
48 words
The crystalline salt according to claim 2 wherein X is chloro, having the following X-ray powder diffraction peaks: ______________________________________
Peak, degrees 2 theta
______________________________________
8.9 19.3 30.5
10.8 20.0 34.1
11.3 22.4 34.5
13.2 22.7 35.9
15.5 23.3 37.5
16.0 26.0 38.5
17.1 27.9 44.8
18.0 30.0
______________________________________
Claim 6
Dependent Claim
31 words
A pharmaceutical composition suitable for treating a bacterial infection in a mammalian subject, which comprises an antibacterially effective amount of a compound according to claim 2 and a pharmaceutically acceptable carrier.
Claim 7
Dependent Claim
19 words
A pharmaceutical composition according to claim 5 in the form of an aqueous suspension for oral administration to children.
Claim 8
Dependent Claim
26 words
A method of treating a bacterial infection in a mammalian subject, which comprises administering thereto an antibacterially effective amount of a compound according to claim 1.
Claim 9
Dependent Claim
12 words
A method according to claim 7 wherein said subject is a child.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-02-20 | 1987-08-22 | 1988-02-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-02-20 | 1991-08-22 | 1992-02-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-02-20 | 1995-08-22 | 1996-02-21 | $7700.00 | Window Closed / Lapsed |