US4432976A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Cyclocarbonate esters of 16α,17α, dihydroxy anti-inflammatory steroids
Assignee: Bayer Pharma AG
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Filing: 1982-08-23
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Granted: 1984-02-21
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Expires: 2002-08-23
Abstract
Abstract Corticoids of Formula I ##STR1## wherein is a single bond or a double bond, X is hydrogen, fluorine, or chlorine, Y represents two hydrogen atoms or an oxygen atom, and Z is hydrogen or acyloxy of 2-6 carbon atoms, are pharmacologically active compounds, e.g., as anti-inflammatories.
Inventors
- 👤 Klaus Annen
- 👤 Henry Laurent
- 👤 Helmut Hofmeister
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 08:04
CPC Classifications
C; C07; C07J; C07J71/00; C07J71/0005; C07J71/0026; C07J71/0031; A; A61; A61P; A61P17/00; A61P37/00; A61P37/08
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
36 words
A corticoid of the formula ##STR6## wherein is a single bond or a double bond, X is hydrogen, fluorine, or chlorine, Y represents an oxygen atom, and Z is hydrogen or alkanoyloxy of 2-6 carbon atoms.
Claim 2
Dependent Claim
36 words
A corticoid of the formula ##STR6## wherein is a single bond or a double bond, X is hydrogen, fluorine, or chlorine, Y represents an oxygen atom, and Z is hydrogen or alkanoyloxy of 2-6 carbon atoms.
Claim 3
Dependent Claim
1 words
21-Chloro-9α-fluoro-11β-hydroxy-16.alpha.,17α-methylenedioxy-1,4-pregnadiene-3,20-dione.
Claim 4
Dependent Claim
1 words
21-Chloro-9α-fluoro-11β-hydroxy-16.alpha.,17α-methylenedioxy-1,4-pregnadiene-3,20-dione.
Claim 5
Dependent Claim
6 words
21-Acetoxy-11β-hydroxy-1,4-pregnadieno[16α,17α-d]-[1,3]dioxolane-2',3,20-trione, a compound of claim 1.
Claim 6
Dependent Claim
6 words
21-Acetoxy-11β-hydroxy-4-pregneno[16α,17α-d]-[1,3]dioxolane-2',3,20-trione, a compound of claim 1.
Claim 7
Dependent Claim
6 words
21-Acetoxy-9α-chloro-11β-hydroxy-1,4-pregnadieno[16α,17α-d]-[1,3]dioxolane-2',3,20-trione, a compound of claim 1.
Claim 8
Dependent Claim
6 words
9α-Chloro-11β,21-dihydroxy-1,4-pregnadieno[16α,17α-d]-[1,3]dioxolane-2',3,20-trione, a compound of claim 1.
Claim 9
Dependent Claim
6 words
21-Acetoxy-9α-chloro-11β-hydroxy-4-pregneno[16α,17α-d]-[1,3]dioxolane-2',3,20-trione, a compound of claim 1.
Claim 10
Dependent Claim
6 words
9α-Chloro-11β-hydroxy-21-propionyloxy-4-pregneno[16α,17α-d]-[1,3]dioxolane-2',3,20-trione, a compound of claim 1.
Claim 11
Dependent Claim
6 words
21-Butyryloxy-9α-chloro-11β-hydroxy-4-pregneno[16α,17α-d]-[1,3]dioxolane-2',3,20-trione, a compound of claim 1.
Claim 12
Dependent Claim
6 words
21-Acetoxy-9.alpha.-fluoro-11β-hydroxy-1,4-pregnadieno[16α,17α-d]-[1,3]dioxolane-2',3,20-trione, a compound of claim 1.
Claim 13
Dependent Claim
19 words
A pharmaceutical composition comprising an antiinflammatorily effective amount of a compound of claim 1 and a pharmaceutically acceptable carrier.
Claim 14
Dependent Claim
14 words
A pharmaceutical composition of claim 11 wherein the carrier is adapted for topical administration.
Claim 15
Dependent Claim
13 words
A pharmaceutical composition of claim 11 containing 1 or 2 antiinflammatorily active ingredients.
Claim 16
Dependent Claim
28 words
A method of treating inflammation in a patient in need of such treatment comprising administering to the patient an antiinflammatorily effective amount of a compound of claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-02-20 | 1987-08-22 | 1988-02-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-02-20 | 1991-08-22 | 1992-02-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-02-20 | 1995-08-22 | 1996-02-21 | $7700.00 | Window Closed / Lapsed |