US4427660A
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Formyl-methionyl chemotatic peptide antibiotic conjugates useful in treating infections
Assignee: Research Corp Technologies Inc
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Filing: 1982-03-03
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Granted: 1984-01-24
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Expires: 2002-03-03
Abstract
Abstract A group of synthetic N-formyl methionine tri and tetra peptides in covalent combination with antibiotics are useful in treating infections. These peptideantibiotic conjugates exhibit a high degree of chemotactic activity for polymorphonuclear leukocytes and monocytes while simultaneously inhibiting the growth of microorganisms. The use of chemotactic peptide-silver sulfadiazine conjugates is particularly effective for treating burns.
Inventors
- 👤 Elliott Schiffman
- 👤 Leonard C. Altman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 04:34
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/10; C07K5/1002; C07K5/1005; C07K5/1013; A; A61; A61K; A61K38/00; A61K38/04; C07K5/08; C07K5/0802; C07K5/0804; C07K5/0808; C07K5/081; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/19; Y10S930/28; Y10S930/29
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
44 words
An N-formyl peptide-antibiotic complex selected from the group consisting of f-Met-Leu-Phe-R, f-Met-Met-Phe-R, f-Met-Met-Met-R, f-Nle-Leu-Phe-R, f-Met-Leu-Phe-Lys-R, and their pharmaceutically acceptable non-toxic acid addition salts, wherein R is an agent selected from the group consisting of sulfonamide antimicrobial agents, silver containing antimicrobial agents, and antifungal agents.
Claim 2
Dependent Claim
44 words
An N-formyl peptide-antibiotic complex selected from the group consisting of f-Met-Leu-Phe-R, f-Met-Met-Phe-R, f-Met-Met-Met-R, f-Nle-Leu-Phe-R, f-Met-Leu-Phe-Lys-R, and their pharmaceutically acceptable non-toxic acid addition salts, wherein R is an agent selected from the group consisting of sulfonamide antimicrobial agents, silver containing antimicrobial agents, and antifungal agents.
Claim 3
Dependent Claim
16 words
The N-formyl peptide-antibiotic complex of claim 1, wherein R is silver sulfadiazine, which is f-Met-Leu-Phe-silver sulfadiazine.
Claim 4
Dependent Claim
16 words
The N-formyl peptide-antibiotic complex of claim 1, wherein R is silver sulfadiazine, which is f-Met-Met-Phe-silver sulfadiazine.
Claim 5
Dependent Claim
16 words
The N-formyl peptide-antibiotic complex of claim 1, wherein R is silver sulfadiazine, which is f-Met-Met-Met-Met-silver sulfadiazine.
Claim 6
Dependent Claim
16 words
The N-formyl peptide-antibiotic complex of claim 1, wherein R is silver sulfadiazine, which is f-Nle-Leu-Phe-silver sulfadiazine.
Claim 7
Dependent Claim
16 words
The N-formyl peptide-antibiotic complex of claim 1, wherein R is silver sulfadiazine, which is f-Met-Leu-Phe-Lys-silver sulfadiazine.
Claim 8
Dependent Claim
12 words
The N-formyl peptides of claim 1 wherein said antifungal agent is miconazole.
Claim 9
Dependent Claim
12 words
The N-formyl peptides of claim 1 wherein said antifungal agent is clotrimazole.
Claim 10
Dependent Claim
12 words
The N-formyl peptides of claim 1 wherein said antifungal agent is nystatin.
Claim 11
Dependent Claim
13 words
The N-formyl peptides of claim 1 wherein said antifungal agent is amphotericin B.
Claim 12
Dependent Claim
20 words
A method of treating septic trauma comprising the application of a pharmacologically effective amount of the compounds of claim 1.
Claim 13
Independent Claim
16 words
A method of treating burns comprising the application of a pharmacologically effective amount of formyl-methionyl-leucyl-phenylalanine-silver sulfadiazine.
Claim 14
Independent Claim
16 words
A method of treating burns comprising the application of a pharmacologically effective amount of formyl-methionyl-leucyl-phenylalanine-silver sulfadiazine.
Claim 15
Dependent Claim
21 words
A method of treating a burn victim comprising the application of a pharmacologically effective amount of the compounds of claim 1.
Claim 16
Dependent Claim
20 words
A method of treating fungal infections comprising the application of a pharmacologically effective amount of the compounds of claim 1.
Claim 17
Dependent Claim
40 words
A method of treating as in claim 12 wherein the pharmacologically effective amount of chemotactic-antibiotic complex is supplied topically to create a concentration gradient wherein the concentration is higher at the trauma site and progressively lower in the surrounding tissue.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-01-23 | 1987-07-25 | 1988-01-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-01-23 | 1991-07-25 | 1992-01-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-01-23 | 1995-07-25 | 1996-01-24 | $7700.00 | Window Closed / Lapsed |