US4427649A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical compositions
Assignee: Imperial Chemical Industries Ltd
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Filing: 1981-12-31
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Granted: 1984-01-24
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Expires: 2001-12-31
Abstract
Abstract Pharmaceutical liposome compositions containing an anti-inflammatory steroid derivative bearing a lipophilic substituent, for example cortisol 21-hexadecanoate. Method of treatment of inflammation at a site involving an enclosed cavity, for example the treatment of rheumatic disease, comprising injecting a said pharmaceutical liposome composition into said cavity. Specified new steroid derivatives, for example fluocinolone acetamide 21-hexadecanoate.
Inventors
- 👤 John T. Dingle
- 👤 John L. Gordon
- 👤 Geraint Jones
- 👤 Clive G. Knight
- 👤 John S. Lowe
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:35
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; A61P; A61P29/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
93 words
A method for the treatment of inflammation at a site involving an enclosed cavity, in a host in need of such treatment, which comprises administering into said cavity an effective amount of a pharmaceutical composition comprising liposomes containing an anti-inflammatory corticosteroid bearing an 11-hydroxy substituent and bearing a lipophilic substituent which is attached by means of a carboxylic ester linkage to the residue of a hydroxy group which itself is attached to the 21-position of the corticosteroid, the said lipophilic substituent comprising an acyclic aliphatic chain of 15, 16 or 17 carbon atoms.
Claim 2
Independent Claim
93 words
A method for the treatment of inflammation at a site involving an enclosed cavity, in a host in need of such treatment, which comprises administering into said cavity an effective amount of a pharmaceutical composition comprising liposomes containing an anti-inflammatory corticosteroid bearing an 11-hydroxy substituent and bearing a lipophilic substituent which is attached by means of a carboxylic ester linkage to the residue of a hydroxy group which itself is attached to the 21-position of the corticosteroid, the said lipophilic substituent comprising an acyclic aliphatic chain of 15, 16 or 17 carbon atoms.
Claim 3
Dependent Claim
19 words
A method as claimed in claim 1 in which the enclosed cavity is a joint affected by rheumatic disease.
Claim 4
Dependent Claim
32 words
A method as claimed in claim 1 in which the anti-inflammatory corticosteroid bears a straight-chain alkanoyloxy substituent of 16 or 18 carbon atoms which is attached to the 21-position of said corticosteroid.
Claim 5
Dependent Claim
40 words
A method as claimed in claim 2 in which the anti-inflammatory corticosteroid bears a straight-chain alkanoyloxy substituent of 16 or 18 carbon atoms which is attached to the 21-position of said corticosteroid, and the composition is administered by intra-articular injection.
Claim 6
Dependent Claim
15 words
A method as claimed in claim 1 in which the anti-inflammatory corticosteroid is cortisol 21-hexadecanoate.
Claim 7
Dependent Claim
16 words
A method as claimed in claim 1 in which the anti-inflammatory corticosteroid is fluocinolone acetonide 21-hexadecanoate.
Claim 8
Dependent Claim
15 words
A method as claimed in claim 1 in which the anti-inflammatory corticosteroid is dexamethasone 21-hexadecanoate.
Claim 9
Dependent Claim
15 words
A method as claimed in claim 1 in which the anti-inflammatory corticosteroid is prednisolone 21-hexadecanoate.
References Cited (Backward Citations)
DE2249552A1
Cited
DE2532317A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-01-23 | 1987-07-25 | 1988-01-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-01-23 | 1991-07-25 | 1992-01-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-01-23 | 1995-07-25 | 1996-01-24 | $7700.00 | Window Closed / Lapsed |