US4427631A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Povidone irradiation
Assignee: Euro Celtique SA
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Filing: 1982-05-27
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Granted: 1984-01-24
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Expires: 2002-05-27
Abstract
Abstract Sterilized povidone-iodine (polyvinylpyrrolidone-iodine) is obtained by irradiating povidone-iodine in the presence of iodide ions. Preferably the irradiation is effected in the presence of iodine and both iodide and iodate ions. The iodide ions, with or without iodate ions, have the effect of preventing the degradation of povidone-iodine and the gelation of iodine and povidone.
Inventors
- 👤 Thomas G. Bunting
- 👤 Dominic A. Centrone
- 👤 Richard S. Sackler
- 👤 Alfred Halpern
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:45
CPC Classifications
A; A61; A61L; A61L2/00; A61L2/02; A61L2/08; A61L2/081; A61L2103/00; A61L2103/05
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
102 words
Method for the sterilization of povidone solutions without degradation thereof and without gelation of the povidone, which comprises subjecting a solution of povidone in the presence of iodine and iodide ions to gamma radiation in a dose sufficiently high to cause gelation of said povidone in the absence of said iodine and said iodide ions, said iodine and said iodide ions being present in an amount and in an iodine to iodide ratio sufficient to prevent said gamma radiation dose from causing said povidone to gel, whereby said solution is sterilized without degradation or gelation thereof and without loss of available iodine.
Claim 2
Dependent Claim
102 words
Method for the sterilization of povidone solutions without degradation thereof and without gelation of the povidone, which comprises subjecting a solution of povidone in the presence of iodine and iodide ions to gamma radiation in a dose sufficiently high to cause gelation of said povidone in the absence of said iodine and said iodide ions, said iodine and said iodide ions being present in an amount and in an iodine to iodide ratio sufficient to prevent said gamma radiation dose from causing said povidone to gel, whereby said solution is sterilized without degradation or gelation thereof and without loss of available iodine.
Claim 3
Dependent Claim
18 words
Method according to claim 1 wherein the proportion of iodine to iodide ion is between 1:10 and 10:1.
Claim 4
Dependent Claim
24 words
Method according to claim 1 wherein the amount of iodine is between about 0.1 and 1% by weight of the amount of said povidone.
Claim 5
Dependent Claim
16 words
Method according to claim 1 wherein the proportion of iodine to iodide ion is about 2:1.
Claim 6
Dependent Claim
18 words
Method according to claim 1 wherein the source of iodide ions is an inorganic or organic iodide salt.
Claim 7
Dependent Claim
11 words
Method according to claim 1 wherein iodate ions are also present.
Claim 8
Dependent Claim
14 words
Method according to claim 6 and wherein the source of said iodine is povidone-iodine.
Claim 9
Dependent Claim
13 words
Method according to claim 1 wherein the source of said iodine is povidone-iodine.
Claim 10
Dependent Claim
23 words
Method according to claim 8 wherein the amount of iodine is between 0.1 and 1% by weight of the amount of said povidone.
Claim 11
Dependent Claim
18 words
Method according to claim 1 wherein the proportion of iodine to iodide ion is between 100:1 and 1:100.
Claim 12
Dependent Claim
20 words
Method according to claim 10 wherein the amount of iodine is about 0.1% to 20% by weight of the povidone.
Claim 13
Dependent Claim
16 words
Method according to claim 1 wherein the source of iodide ions is an inorganic iodide salt.
Claim 14
Dependent Claim
21 words
Method according to claim 12 wherein iodate ions are present in an amount by weight substantially equal to the iodide salt.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-01-23 | 1987-07-25 | 1988-01-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-01-23 | 1991-07-25 | 1992-01-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-01-23 | 1995-07-25 | 1996-01-24 | $7700.00 | Window Closed / Lapsed |