US4426384A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Treatment of rheumatoid arthritis and related diseases
Assignee: SIMOONS JOHN RA
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Filing: 1982-08-05
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Granted: 1984-01-17
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Expires: 2002-08-05
Abstract
Abstract It is believed that rheumatoid arthritis and related collagen and auto-immune diseases are an infection and that various species of free-living (limax) amoebae are the aetiological agent of these diseases. It has been discovered that pyrimidines with anti-protozoal activity, are effective for the treatment of rheumatoid arthritis and other collagen and auto-immune (rheumatoid) diseases.
Inventors
- 👤 Roger Wyburn-Mason
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 12:20
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/495; A61K31/505
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
53 words
A method for producing remission in patients suffering from active rheumatoid arthritis which comprises administering orally to such a patient an effective amount of a compound of the formula: ##STR2## wherein R' is amino, hydroxy or mercapto and R 2 is hydrogen, mercapto or hydroxyl and the pharmaceutically acceptable acid addition salt thereof.
Claim 2
Independent Claim
53 words
A method for producing remission in patients suffering from active rheumatoid arthritis which comprises administering orally to such a patient an effective amount of a compound of the formula: ##STR2## wherein R' is amino, hydroxy or mercapto and R 2 is hydrogen, mercapto or hydroxyl and the pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
14 words
The method of claim 1 wherein R' is hydroxy and R 2 is hydrogen.
Claim 4
Dependent Claim
24 words
The method of claim 1, wherein the compound is administered orally in doses of approximately 12 mg. per kilogram of body weight per day.
Claim 5
Dependent Claim
39 words
The method of combating rheumatoid arthritis of claim 3 which comprises orally administering to the infected subject allopurinol in a daily dose amount of about 300 to about 1800 mgms for about ten days and repeated every six months.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-01-16 | 1987-07-18 | 1988-01-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-01-16 | 1991-07-18 | 1992-01-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-01-16 | 1995-07-18 | 1996-01-17 | $7700.00 | Window Closed / Lapsed |