US4423229A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Composition of matter and process
Assignee: Pharmacia and Upjohn Co
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Filing: 1982-02-08
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Granted: 1983-12-27
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Expires: 2002-02-08
Abstract
Abstract Novel antibacterially-active compound, 1,2,8,8a-cyclopropa[ c]-benzo[1,2-b:-4,3-b']dipyrol-4(5H)-one, prepared by a novel chemical process. This compound, as well as antibacterially-active intermediates, can be used to eradicate or control susceptible bacteria, for example, B. subtilis, K. pneumonia, S. lutea, S. aureus, and M. avium.
Inventors
- 👤 Wendell Wierenga
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 22:23
CPC Classifications
C; C07; C07D; C07D487/00; C07D487/02; C07D487/06; C07D209/00; C07D209/02; C07D209/04; C07D209/10; C07D209/12
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
146 words
A process for preparing a compound of the formula wherein R 2 and R 3 are hydrogen, alkyl of from 1 to 5 carbon atoms, inclusive, and phenyl; R 4 is selected from the group consisting of SO 2 R 2 , SO 2 CH 2 COphenyl, CO 2 CH 2 Z where Z is selected from the group consisting of CH 2 I, CCl 3 , CH 2 SO 2 R 2 , phenyl, and fluorenylmethyl, which comprises reacting a compound of the formula ##STR3## wherein R 2 , R 3 , and R 4 , are as defined above, and X is selected from the group consisting of OSO 2 R 2 , Cl, Br, and I, with triphenylphosphine/carbon tetrahalide, concentrating the reaction mixture in vacuo to a concentrate and applying said concentrate to a thick-layer silica gel plate to give the desired compound.
Claim 2
Dependent Claim
146 words
A process for preparing a compound of the formula wherein R 2 and R 3 are hydrogen, alkyl of from 1 to 5 carbon atoms, inclusive, and phenyl; R 4 is selected from the group consisting of SO 2 R 2 , SO 2 CH 2 COphenyl, CO 2 CH 2 Z where Z is selected from the group consisting of CH 2 I, CCl 3 , CH 2 SO 2 R 2 , phenyl, and fluorenylmethyl, which comprises reacting a compound of the formula ##STR3## wherein R 2 , R 3 , and R 4 , are as defined above, and X is selected from the group consisting of OSO 2 R 2 , Cl, Br, and I, with triphenylphosphine/carbon tetrahalide, concentrating the reaction mixture in vacuo to a concentrate and applying said concentrate to a thick-layer silica gel plate to give the desired compound.
References Cited (Backward Citations)
US4351842A
Cited
US4169888A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-12-26 | 1987-06-27 | 1987-12-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-12-26 | 1991-06-27 | 1991-12-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-12-26 | 1995-06-27 | 1995-12-27 | $7700.00 | Window Closed / Lapsed |