US4423147A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Monoclonal antibody to interferon-α
Assignee: Individual
•
Filing: 1981-04-13
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Granted: 1983-12-27
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Expires: 2001-04-13
Abstract
Abstract A monoclonal antibody is described characterized by its specificity to interferon-α (leukocyke interferon). Preferably the antibody has specificity to human interferon-α. The monoclonal antibody is secreted by a hybrid cell formed by the fusion of lymphocyte cells derived from an animal immunized with interferon-α, with mycloma cells. The antibody has applications in the purification of interferon. It may be covalently attached to a solid support and used as an immunoadsorbent. Purifications of up to 5000 fold may be obtained in a single pass through an immunoadsorption column of this type. An immunoradiometric assay for interferon-α is also described.
Inventors
- 👤 David S. Secher
- 👤 Derek C. Burke
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:43
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/18; C07K16/24; C07K16/249; Y; Y10; Y10S; Y10S435/00; Y10S435/811; Y10S436/00; Y10S436/815; Y10S436/824; Y10S530/00; Y10S530/808; Y10S530/863; Y10S530/864; Y10T; Y10T436/00; Y10T436/25; Y10T436/25375; Y10T436/255
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
23 words
A monoclonal antibody produced by a murine derived hybrid cell line wherein the antibody is capable of specifically binding to at least one
Claim 2
Dependent Claim
23 words
A monoclonal antibody produced by a murine derived hybrid cell line wherein the antibody is capable of specifically binding to at least one
Claim 3
Dependent Claim
22 words
A monoclonal antibody according to claim 1 wherein the antibody is capable of specifically binding to at least one antigenic determinant of
Claim 4
Dependent Claim
13 words
A monoclonal antibody according to claim 1 or 2 wherein the antibody is
Claim 5
Dependent Claim
13 words
A monoclonal antibody according to claim 1 for use in a process for
Claim 6
Dependent Claim
11 words
A monoclonal antibody according to claim 1 for use in an
Claim 7
Dependent Claim
11 words
A monoclonal antibody according to claim 1 in an immunoassay for
Claim 8
Dependent Claim
33 words
An immunopurification process for extracting interferon-αfrom a sample containing interferon-α wherein the sample is passed through an immunoabsorbent column comprising a monoclonal antibody according to claim 1 bound to a solid phase support.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-12-26 | 1987-06-27 | 1987-12-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-12-26 | 1991-06-27 | 1991-12-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-12-26 | 1995-06-27 | 1995-12-27 | $7700.00 | Window Closed / Lapsed |