US4420566A
Expired / Lapsed
US
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Method and apparatus for detecting sample fluid on an analysis slide
Assignee: Clinical Diagnostic Systems Inc
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Filing: 1982-06-10
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Granted: 1983-12-13
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Expires: 2002-06-10
Abstract
Abstract A method and apparatus are disclosed for detecting sample fluid on an analysis slide of the type which is used to perform quantitative analyses. The apparatus comprises means for projecting radiation comprising wavelengths absorbed by water onto the slide and means for measuring the intensity of radiation received from the slide, both before fluid is metered on the slide and after fluid has been metered thereon. The difference between radiation received from a wet slide and from a dry slide is compared with known values to determine if the slide contains sufficient fluid for a suitable test result.
Inventors
- 👤 Thomas C. Jessop
- 👤 Donald De Jager
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:09
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/84; G01N21/8483; G01N35/00; G01N35/00029; G01N35/10; G01N35/1009; G01N35/1016; Y; Y10; Y10T; Y10T436/00; Y10T436/11; Y10T436/110833; Y10T436/112499
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
216 words
Apparatus for detecting a sample fluid containing a substantial portion of water on a test element adapted to receive a predetermined quantity of the sample fluid from a metering device and to produce a response proportional to a selected analyte in the fluid, an element being of a type for the selected analyte and having certain reflectance characteristics, said apparatus comprising: means for projecting a beam of radiation comprising wavelengths absorbed by water onto a surface of a test element; sensor means for detecting the intensity of radiation within the absorption band of water reflected from a surface of a test element and for producing an output proportional to said intensity, said sensor means being adapted to produce a first output from radiation received before fluid is metered onto an element and a second output after fluid is metered thereon; and means for processing said outputs, said processing means including means for receiving an input indicative of the reflectance characteristics of said type of test element and for comparing the difference between said first and second outputs with a predetermined value which corresponds to a sufficient amount of fluid on said type of test element, and means for producing a signal in the event the amount of fluid is not sufficient to produce a proper response.
Claim 2
Dependent Claim
216 words
Apparatus for detecting a sample fluid containing a substantial portion of water on a test element adapted to receive a predetermined quantity of the sample fluid from a metering device and to produce a response proportional to a selected analyte in the fluid, an element being of a type for the selected analyte and having certain reflectance characteristics, said apparatus comprising: means for projecting a beam of radiation comprising wavelengths absorbed by water onto a surface of a test element; sensor means for detecting the intensity of radiation within the absorption band of water reflected from a surface of a test element and for producing an output proportional to said intensity, said sensor means being adapted to produce a first output from radiation received before fluid is metered onto an element and a second output after fluid is metered thereon; and means for processing said outputs, said processing means including means for receiving an input indicative of the reflectance characteristics of said type of test element and for comparing the difference between said first and second outputs with a predetermined value which corresponds to a sufficient amount of fluid on said type of test element, and means for producing a signal in the event the amount of fluid is not sufficient to produce a proper response.
Claim 3
Dependent Claim
23 words
Apparatus, as defined in claim 1, wherein said means for projecting a beam of radiation is an incandescent lamp having a lens end.
Claim 4
Dependent Claim
34 words
Apparatus, as defined in claim 1, wherein said sensor means includes a lead sulfide cell having an integral notch filter which passes a narrow band of radiation which includes a wavelength of 1.945 microns.
Claim 5
Dependent Claim
24 words
Apparatus, as defined in claim 1, wherein said means for projecting a beam of radiation and said sensor means are positioned above an element.
Claim 6
Dependent Claim
24 words
Apparatus, as defined in claim 1, wherein said means for projecting a beam of radiation and said sensor means are positioned below an element.
Claim 7
Dependent Claim
34 words
Apparatus, as defined in claim 5, wherein means are provided for projecting a beam of radiation on a top surface of an element, and said sensor means detects the intensity of radiation transmitted therethrough.
Claim 8
Dependent Claim
54 words
Apparatus, as defined in claim 1, wherein means is provided for supporting an element for movement relative to said sensor means, and said processing means is adapted to integrate the output received from said sensor means as an element is moved relative to the sensor means and to predict a drop volume based thereon.
Claim 9
Dependent Claim
44 words
Apparatus, as defined in claim 1, wherein said means for projecting a beam includes means for projecting an annular image onto a surface of a test element, and the interior diameter of said image is sized according to a desired quantity of sample fluid.
Claim 10
Dependent Claim
23 words
Apparatus, as defined in claim 8, wherein the means for processing said outputs comprises means for predicting drop volume based on said outputs.
Claim 11
Independent Claim
254 words
A method for detecting a sample fluid containing a substantial portion of water on an analysis slide, said slide being adapted to receive a predetermined quantity of sample fluid and to produce a response proportional to a selected analyte in the fluid, said slide being selected from more than one type, each type being for a particular analyte and having a defined range of values of reflectivity which varies between a relatively high reflectivity when the slide does not contain any fluid and a relatively low reflectivity after fluid has been deposited on the slide, said method comprising the steps of: (a) projecting radiation comprising wavelengths absorbed by water onto a dry slide before the metering of fluid thereon; (b) detecting the intensity of radiation within the absorption band of water reflected from said dry slide; (c) projecting radiation comprising wavelengths absorbed by water onto said slide after the metering of fluid thereon; (d) detecting the intensity of radiation within the absorption band of water reflected from said slide after the metering of fluid onto the slide; (e) comparing the difference between the intensity of radiation reflected from said dry slide and from said slide after fluid has been metered thereon with a predetermined value within the reflectivity range of the type of slide suitable for said selected analyte to determine if sufficient fluid has been metered onto the slide to produce a proper response; and (f) producing a signal in the event the amount of fluid is not sufficient for a proper response.
Claim 12
Independent Claim
254 words
A method for detecting a sample fluid containing a substantial portion of water on an analysis slide, said slide being adapted to receive a predetermined quantity of sample fluid and to produce a response proportional to a selected analyte in the fluid, said slide being selected from more than one type, each type being for a particular analyte and having a defined range of values of reflectivity which varies between a relatively high reflectivity when the slide does not contain any fluid and a relatively low reflectivity after fluid has been deposited on the slide, said method comprising the steps of: (a) projecting radiation comprising wavelengths absorbed by water onto a dry slide before the metering of fluid thereon; (b) detecting the intensity of radiation within the absorption band of water reflected from said dry slide; (c) projecting radiation comprising wavelengths absorbed by water onto said slide after the metering of fluid thereon; (d) detecting the intensity of radiation within the absorption band of water reflected from said slide after the metering of fluid onto the slide; (e) comparing the difference between the intensity of radiation reflected from said dry slide and from said slide after fluid has been metered thereon with a predetermined value within the reflectivity range of the type of slide suitable for said selected analyte to determine if sufficient fluid has been metered onto the slide to produce a proper response; and (f) producing a signal in the event the amount of fluid is not sufficient for a proper response.
Claim 13
Dependent Claim
19 words
A method, as recited in claim 10, wherein the intensity of said radiation is detected in the infrared region.
Claim 14
Dependent Claim
37 words
A method, as recited in claim 10, wherein said radiation is projected onto the slide to form an annular image, and the interior diameter of the image is sized according to a desired quantity of sample fluid.
Claim 15
Dependent Claim
200 words
Apparatus for determining the volume of fluid on an analysis slide which is one of a plurality of types, each type being for a particular analyte and having a defined range of values for reflectivity, said apparatus comprising: a radiation source for projecting a beam of radiation comprising wavelengths absorbed by water onto a defined area of a surface of a slide; sensor means for detecting the intensity of radiation reflected from said area and for producing an output proportional to said intensity, said sensor means being adapted to produce a first output from radiation received from said area before fluid is metered onto a slide and a second output from radiation received from the area after fluid is metered onto a slide; and means for processing said first and second outputs, said processing means including means for storing the range of values which corresponds to the type of slide and for receiving an input indicative of the type of slide, and said processing means having means for comparing the difference between said first and second outputs with the stored range of values and for predicting the volume of fluid on a slide based on the value of said difference.
Claim 16
Dependent Claim
200 words
Apparatus for determining the volume of fluid on an analysis slide which is one of a plurality of types, each type being for a particular analyte and having a defined range of values for reflectivity, said apparatus comprising: a radiation source for projecting a beam of radiation comprising wavelengths absorbed by water onto a defined area of a surface of a slide; sensor means for detecting the intensity of radiation reflected from said area and for producing an output proportional to said intensity, said sensor means being adapted to produce a first output from radiation received from said area before fluid is metered onto a slide and a second output from radiation received from the area after fluid is metered onto a slide; and means for processing said first and second outputs, said processing means including means for storing the range of values which corresponds to the type of slide and for receiving an input indicative of the type of slide, and said processing means having means for comparing the difference between said first and second outputs with the stored range of values and for predicting the volume of fluid on a slide based on the value of said difference.
Claim 17
Dependent Claim
24 words
Apparatus, as defined in claim 13, wherein said radiation source is a lamp which produces radiation in the spectral band which includes 1.945 microns.
Claim 18
Dependent Claim
26 words
Apparatus, as defined in claim 13, wherein means which includes an annulus is interposed between said source and a slide and said defined area is annular.
Claim 19
Dependent Claim
18 words
Apparatus, as defined in claim 13, wherein an optical chopper is interposed between said source and a slide.
Claim 20
Dependent Claim
196 words
Apparatus for detecting a sample fluid containing a substantial portion of water on a test element adapted to receive a predetermined quantity of sample fluid from a metering device and to produce a response proportional to a selected analyte in the fluid, an element being selected from more than one type, each type being for a particular analyte, said apparatus comprising: means for projecting a beam of radiation comprising wavelengths absorbed by water onto a surface of an element; sensor means for detecting the intensity of radiation within the absorption band of water reflected from a surface of an element and for producing an output proportional to said intensity, said sensor means being adapted to produce an output after fluid is metered onto a test element; and means for processing said output, said processing means including means for receiving an input indicative of the type of element and for comparing said output with a predetermined value corresponding to a reflectivity which represents a sufficient amount of fluid on a test element, and said processing means having means for producing a signal in the event the amount of fluid is not sufficient to produce a proper response.
Claim 21
Dependent Claim
196 words
Apparatus for detecting a sample fluid containing a substantial portion of water on a test element adapted to receive a predetermined quantity of sample fluid from a metering device and to produce a response proportional to a selected analyte in the fluid, an element being selected from more than one type, each type being for a particular analyte, said apparatus comprising: means for projecting a beam of radiation comprising wavelengths absorbed by water onto a surface of an element; sensor means for detecting the intensity of radiation within the absorption band of water reflected from a surface of an element and for producing an output proportional to said intensity, said sensor means being adapted to produce an output after fluid is metered onto a test element; and means for processing said output, said processing means including means for receiving an input indicative of the type of element and for comparing said output with a predetermined value corresponding to a reflectivity which represents a sufficient amount of fluid on a test element, and said processing means having means for producing a signal in the event the amount of fluid is not sufficient to produce a proper response.
Claim 22
Dependent Claim
206 words
Apparatus for detecting a sample fluid containing a substantial portion of water on a test element, said element being adapted to receive a predetermined quantity of sample fluid from a metering device and to produce a response proportional to a selected analyte in the fluid, an element being selected from more than one type, each type being for a particular analyte, said apparatus comprising: means for projecting radiation comprising wavelengths absorbed by water onto an element; sensor means for detecting the intensity of radiation within the absorption band of water received from an element and for producing an output proportional to said intensity, said sensor means being adapted to produce a first output from radiation received before fluid is metered onto an element and a second output after fluid is metered onto an element; and means for processing said outputs, said processing means including means for receiving an input indicative of the type of element and for comparing the difference between said first and second outputs with a predetermined value which corresponds to a sufficient amount of fluid on an element, and said processing means having means for producing a signal in the event the amount of fluid is not sufficient to produce a proper response.
Claim 23
Dependent Claim
206 words
Apparatus for detecting a sample fluid containing a substantial portion of water on a test element, said element being adapted to receive a predetermined quantity of sample fluid from a metering device and to produce a response proportional to a selected analyte in the fluid, an element being selected from more than one type, each type being for a particular analyte, said apparatus comprising: means for projecting radiation comprising wavelengths absorbed by water onto an element; sensor means for detecting the intensity of radiation within the absorption band of water received from an element and for producing an output proportional to said intensity, said sensor means being adapted to produce a first output from radiation received before fluid is metered onto an element and a second output after fluid is metered onto an element; and means for processing said outputs, said processing means including means for receiving an input indicative of the type of element and for comparing the difference between said first and second outputs with a predetermined value which corresponds to a sufficient amount of fluid on an element, and said processing means having means for producing a signal in the event the amount of fluid is not sufficient to produce a proper response.
Claim 24
Dependent Claim
34 words
Apparatus, as defined in claim 18, wherein said means for projecting radiation comprises means for projecting a beam of radiation onto an element, and said sensor means detects the intensity of radiation transmitted therethrough.
Claim 25
Dependent Claim
37 words
Apparatus, as defined in claim 18, wherein said means for projecting radiation comprises means for projecting a beam of radiation on one surface of an element, and said sensor means detects the intensity of radiation reflected therefrom.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-12-12 | 1987-06-13 | 1987-12-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-12-12 | 1991-06-13 | 1991-12-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-12-12 | 1995-06-13 | 1995-12-13 | $7700.00 | Window Closed / Lapsed |