US4416891A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Ester of 6-[(hexahydro-1H-azepin-1-yl)methyleneamino]penicillanic acid, and its use as antibacterial agent
Assignee: Kanebo Ltd
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Filing: 1982-07-16
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Granted: 1983-11-22
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Expires: 2002-07-16
Abstract
Abstract (5-Methyl-2-oxo-1,3-dioxolen-4-yl)methyl 6-[(hexahydro-1H-azepin-1-yl)methyleneamino]penicillanate of the following formula (I) ##STR1## or its pharmaceutically acceptable acid addition salt. The compound is useful as an antibacterial agent and may be prepared by reacting (5-methyl-2-oxo-1,3-dioxolen-4-yl)-methyl 6-aminopenicillanate of the following formula (II) ##STR2## or its acid addition salt with chloro-N,N-hexamethyleneformiminium chloride, and as required, converting the resulting compound to its pharmaceutically acceptable acid addition salt.
Inventors
- 👤 Fumio Sakamoto
- 👤 Shoji Ikeda
- 👤 Goro Tsukamoto
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 02:03
CPC Classifications
C; C07; C07D; C07D499/00; A; A61; A61P; A61P31/00; A61P31/04; C07D317/00; C07D317/08; C07D317/10; C07D317/32; C07D317/34; C07D317/40
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
16 words
(5-Methyl-2-oxo-1,3-dioxolen-4-yl)methyl 6-[(hexahydro-1H-azepin-1-yl)methyleneamino]penicillanate of the following formula (I) ##STR21## or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
16 words
(5-Methyl-2-oxo-1,3-dioxolen-4-yl)methyl 6-[(hexahydro-1H-azepin-1-yl)methyleneamino]penicillanate of the following formula (I) ##STR21## or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
26 words
An antibacterial agent comprising an antibacterially effective amount of (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl 6-[(hexahydro-1H-azepin-1-yl)methyleneamino]penicillanate or a pharmaceutically acceptable acid addition salt thereof in association with a pharmaceutically acceptable carrier.
Claim 4
Dependent Claim
26 words
An antibacterial agent comprising an antibacterially effective amount of (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl 6-[(hexahydro-1H-azepin-1-yl)methyleneamino]penicillanate or a pharmaceutically acceptable acid addition salt thereof in association with a pharmaceutically acceptable carrier.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-11-21 | 1987-05-23 | 1987-11-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-11-21 | 1991-05-23 | 1991-11-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-11-21 | 1995-05-23 | 1995-11-22 | $7700.00 | Window Closed / Lapsed |