US4415559A
Expired / Lapsed
US
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Anticoagulant
Assignee: Eisai Co Ltd
•
Filing: 1982-02-04
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Granted: 1983-11-15
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Expires: 2002-02-04
Abstract
Abstract An anticoagulant containing heparin having low antithrombin III affinity as an effective ingredient.
Inventors
- 👤 Suguru Suzuki
- 👤 Noritoshi Sano
- 👤 Tetsuya Tajima
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:28
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/715; A61K31/726; A61K31/727; A61K9/00; A61K9/0012; A61K9/0019; A61P; A61P7/00; A61P7/02
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
57 words
A method of treating a mammal to inhibit endogenous coagulation of the circulating blood which comprises administering to said mammal, by intravenous administration or intramuscular injection, a therapeutically effective amount of an anticoagulant composition consisting essentially of heparin having low antithrombin III affinity as an effective ingredient, in combination with a pharmacologically acceptable carrier, diluent or vehicle.
Claim 2
Independent Claim
57 words
A method of treating a mammal to inhibit endogenous coagulation of the circulating blood which comprises administering to said mammal, by intravenous administration or intramuscular injection, a therapeutically effective amount of an anticoagulant composition consisting essentially of heparin having low antithrombin III affinity as an effective ingredient, in combination with a pharmacologically acceptable carrier, diluent or vehicle.
Claim 3
Dependent Claim
36 words
A method as claimed in claim 1 wherein said heparin having low antithrombin III affinity is a heparin which is not adsorbed by lattice-bound antithrombin III at a physiological pH and in a physiological salt concentration.
Claim 4
Dependent Claim
21 words
A method as claimed in claim 2 wherein said physiological pH is in the range of pH 7 to pH 8.
Claim 5
Dependent Claim
30 words
A method as claimed in claim 2 or claim 3 wherein said physiological salt concentration is in the range of 0.05 M to 0.20 M, calculated as sodium chloride concentration.
Claim 6
Dependent Claim
16 words
A method as claimed in claim 2 or claim 3 wherein said lattice is cephalose CL-4B.
Claim 7
Dependent Claim
13 words
A method as defined in claim 4 wherein said lattice is cephalose CL-4B.
Claim 8
Dependent Claim
39 words
A method as claimed in claim 1, wherein said anticoagulant composition is in the form of an injectable liquid composition consisting of a therapeutically effective amount of said heparin having low antithrombin III affinity and water or isotonic saline.
Claim 9
Independent Claim
56 words
A method of treating a human being to inhibit the endogenous coagulation of the circulating blood which comprises administering to said human being, by intravenous administration or intramuscular injection, a therapeutically effective amount of a liquid anticoagulant composition consisting of a therapeutically effective amount of heparin having low antithrombin III affinity, and water or isotonic saline.
Claim 10
Independent Claim
56 words
A method of treating a human being to inhibit the endogenous coagulation of the circulating blood which comprises administering to said human being, by intravenous administration or intramuscular injection, a therapeutically effective amount of a liquid anticoagulant composition consisting of a therapeutically effective amount of heparin having low antithrombin III affinity, and water or isotonic saline.
References Cited (Backward Citations)
US4119774A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-11-14 | 1987-05-16 | 1987-11-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-11-14 | 1991-05-16 | 1991-11-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-11-14 | 1995-05-16 | 1995-11-15 | $7700.00 | Window Closed / Lapsed |